5L4K
The human 26S proteasome lid
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth W] | d5l4kw_ | Alpha and beta proteins (a/b) | vWA-like | vWA-like | Integrin A (or I) domain | Proteasome regulatory subunit Rpn10 | (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
B [auth V] | SCOP2B Superfamily | JAB1/MPN domain-like | 8053255 | 3001105 | SCOP2B (2022-06-29) |
B [auth V] | SCOP2B Superfamily | EIF3 subunit F C-terminal domain-like | 8053254 | 3002167 | SCOP2B (2022-06-29) |
I [auth Q] | SCOP2B Superfamily | Winged helix DNA-binding domain | 8067905 | 3000034 | SCOP2B (2022-06-29) |
K [auth U] | SCOP2B Superfamily | JAB1/MPN domain-like | 8053252 | 3001105 | SCOP2B (2022-06-29) |
K [auth U] | SCOP2B Superfamily | EIF3 subunit F C-terminal domain-like | 8053251 | 3002167 | SCOP2B (2022-06-29) |
J [auth R] | SCOP2B Superfamily | Winged helix DNA-binding domain | 8057047 | 3000034 | SCOP2B (2022-06-29) |
J [auth R] | SCOP2B Superfamily | TPR-like | 8057045 | 3001345 | SCOP2B (2022-06-29) |
D [auth Y] | SCOP2B Superfamily | DSS1/SEM1 protein family | 8053396 | 3002183 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth W] | PF13519 | e5l4kW1 | A: a/b three-layered sandwiches | X: HAD domain-like | H: HAD domain-related | T: vWA-like | F: PF13519 | ECOD (1.6) |
B [auth V] | PF01398 | e5l4kV2 | A: a+b three layers | X: Cytidine deaminase-like (From Topology) | H: Cytidine deaminase-like (From Topology) | T: Cytidine deaminase-like | F: PF01398 | ECOD (1.6) |
B [auth V] | F_UNCLASSIFIED | e5l4kV1 | A: extended segments | X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology) | H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology) | T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain | F: F_UNCLASSIFIED | ECOD (1.6) |
C [auth T] | PF10075 | e5l4kT2 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF10075 | ECOD (1.6) |
C [auth T] | PF10075 | e5l4kT1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF10075 | ECOD (1.6) |
H [auth P] | PF01399 | e5l4kP3 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF01399 | ECOD (1.6) |
H [auth P] | PF22241 | e5l4kP2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF22241 | ECOD (1.6) |
H [auth P] | PF18098 | e5l4kP1 | A: extended segments | X: 26S proteasome regulatory subunits C-terminal helices | H: 26S proteasome regulatory subunit RPN5 C-terminal helix (From Topology) | T: 26S proteasome regulatory subunit RPN5 C-terminal helix | F: PF18098 | ECOD (1.6) |
I [auth Q] | PF01399 | e5l4kQ1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF01399 | ECOD (1.6) |
I [auth Q] | PF18055 | e5l4kQ3 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF18055 | ECOD (1.6) |
I [auth Q] | PF18503 | e5l4kQ2 | A: extended segments | X: 26S proteasome regulatory subunits C-terminal helices | H: 26S proteasome regulatory subunit RPN6 C-termial helix (From Topology) | T: 26S proteasome regulatory subunit RPN6 C-termial helix | F: PF18503 | ECOD (1.6) |
K [auth U] | PF01398 | e5l4kU2 | A: a+b three layers | X: Cytidine deaminase-like (From Topology) | H: Cytidine deaminase-like (From Topology) | T: Cytidine deaminase-like | F: PF01398 | ECOD (1.6) |
K [auth U] | PF13012 | e5l4kU1 | A: extended segments | X: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology) | H: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain (From Topology) | T: 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain | F: PF13012 | ECOD (1.6) |
J [auth R] | PF01399 | e5l4kR3 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF01399 | ECOD (1.6) |
J [auth R] | PF10602 | e5l4kR1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF10602 | ECOD (1.6) |
J [auth R] | PF21154 | e5l4kR2 | A: extended segments | X: 26S proteasome regulatory subunits C-terminal helices | H: 26S proteasome regulatory subunit RPN7 C-terminal helix (From Topology) | T: 26S proteasome regulatory subunit RPN7 C-terminal helix | F: PF21154 | ECOD (1.6) |
L [auth O] | PF01399 | e5l4kO1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF01399 | ECOD (1.6) |
L [auth O] | PF22037 | e5l4kO2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PF22037 | ECOD (1.6) |
L [auth O] | F_UNCLASSIFIED | e5l4kO3 | A: extended segments | X: 26S proteasome regulatory subunits C-terminal helices | H: 26S proteasome regulatory subunit RPN9 C-terminal helix (From Topology) | T: 26S proteasome regulatory subunit RPN9 C-terminal helix | F: F_UNCLASSIFIED | ECOD (1.6) |
E [auth Z] | PF17781 | e5l4kZ3 | A: alpha superhelices | X: Repetitive alpha hairpins | H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology) | T: 26S proteasome subunit Rpn2 N-terminal domain | F: PF17781 | ECOD (1.6) |
E [auth Z] | PF01851,PF18051 | e5l4kZ2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: Proteasome/cyclosome (PC) repeat (From Topology) | T: Proteasome/cyclosome (PC) repeat | F: PF01851,PF18051 | ECOD (1.6) |
F [auth N] | PF18004 | e5l4kN3 | A: beta sandwiches | X: 26S proteasome subunit Rpn2 C-terminal domain (From Topology) | H: 26S proteasome subunit Rpn2 C-terminal domain (From Topology) | T: 26S proteasome subunit Rpn2 C-terminal domain | F: PF18004 | ECOD (1.6) |
F [auth N] | PF21505 | e5l4kN1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: 26S proteasome subunit Rpn2 N-terminal domain (From Topology) | T: 26S proteasome subunit Rpn2 N-terminal domain | F: PF21505 | ECOD (1.6) |
F [auth N] | PF01851 | e5l4kN2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: Proteasome/cyclosome (PC) repeat (From Topology) | T: Proteasome/cyclosome (PC) repeat | F: PF01851 | ECOD (1.6) |
G [auth S] | PF01399 | e5l4kS2 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF01399 | ECOD (1.6) |
G [auth S] | F_UNCLASSIFIED | e5l4kS1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: F_UNCLASSIFIED | ECOD (1.6) |
G [auth S] | PF08375 | e5l4kS3 | A: extended segments | X: 26S proteasome regulatory subunits C-terminal helices | H: 26S proteasome regulatory subunit RPN3 C-terminal helix (From Topology) | T: 26S proteasome regulatory subunit RPN3 C-terminal helix | F: PF08375 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth W] | PF13519 | von Willebrand factor type A domain (VWA_2) | von Willebrand factor type A domain | - | Domain |
B [auth V] | PF01398 | JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB) | JAB1/Mov34/MPN/PAD-1 ubiquitin protease | - | Family |
C [auth T] | PF10075 | CSN8/PSMD8/EIF3K family (CSN8_PSD8_EIF3K) | CSN8/PSMD8/EIF3K family | - | Family |
H [auth P] | PF18098 | 26S proteasome regulatory subunit RPN5 C-terminal domain (RPN5_C) | 26S proteasome regulatory subunit RPN5 C-terminal domain | This is the C-terminal domain of the 26S proteasome regulatory subunit RPN5 proteins.This helical domain can be found adjacent to Pfam:PF01399. The 26S proteasome is the major ATP-dependent protease in eukaryotes. Three subcomplexes form this degrada ... | Domain |
H [auth P] | PF01399 | PCI domain (PCI) | PCI domain | This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1]. | Domain |
I [auth Q] | PF18055 | 26S proteasome regulatory subunit RPN6 N-terminal domain (RPN6_N) | 26S proteasome regulatory subunit RPN6 N-terminal domain | - | Repeat |
I [auth Q] | PF18503 | 26S proteasome subunit RPN6 C-terminal helix domain (RPN6_C_helix) | 26S proteasome subunit RPN6 C-terminal helix domain | This is the C-terminal helix domain found in RPN6, a component of the 26S proteasome. The C-terminal helices are essential for lid assembly [1, 2]. | Domain |
I [auth Q] | PF01399 | PCI domain (PCI) | PCI domain | This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1]. | Domain |
K [auth U] | PF13012 | Maintenance of mitochondrial structure and function (MitMem_reg) | Maintenance of mitochondrial structure and function | - | Family |
K [auth U] | PF01398 | JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB) | JAB1/Mov34/MPN/PAD-1 ubiquitin protease | - | Family |
J [auth R] | PF21154 | 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix (RPN7_PSMD6_C) | 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix | RPN7/PSDM6 are regulatory subunits from the 26S proteasome. This entry represents the C-terminal helix. | Domain |
J [auth R] | PF01399 | PCI domain (PCI) | PCI domain | This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1]. | Domain |
J [auth R] | PF10602 | 26S proteasome subunit RPN7 (RPN7) | 26S proteasome subunit RPN7 | - | Repeat |
L [auth O] | PF01399 | PCI domain (PCI) | PCI domain | This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1]. | Domain |
D [auth Y] | PF05160 | DSS1/SEM1 family (DSS1_SEM1) | DSS1/SEM1 family | - | Family |
E [auth Z] | PF17781 | RPN1 N-terminal domain (RPN1_RPN2_N) | RPN1 N-terminal domain | This domain is found at the N-terminus of the 26S proteasome regulatory subunits RPN1 (also known as 26S proteasome non-ATPase regulatory subunit 2 (PMSD2)[1]. The domain is formed by an array of alpha helices [2]. | Domain |
E [auth Z] | PF01851 | Proteasome/cyclosome repeat (PC_rep) | Proteasome/cyclosome repeat | - | Repeat |
E [auth Z] | PF18051 | 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal (RPN1_C) | 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal | This is the C-terminal domain found in RPN1 proteins (26S proteasome non-ATPase regulatory subunit 2). The 26S proteasome holocomplex consists of a 28-subunit barrel-shaped core particle (CP) in the center capped at the top and bottom by 19-subunit ... | Domain |
F [auth N] | PF13646 | HEAT repeats (HEAT_2) | HEAT repeats | - | Repeat |
F [auth N] | PF18004 | 26S proteasome regulatory subunit RPN2 C-terminal domain (RPN2_C) | 26S proteasome regulatory subunit RPN2 C-terminal domain | This is the C-terminal domain found in S. cerevisiae Rpn2 (26S proteasome regulatory subunit RPN2) as well as other eukaryotic species. A study revealed that the C-terminal 52 residues of the Rpn2 C-terminal domain are responsible for mediating inter ... | Domain |
F [auth N] | PF01851 | Proteasome/cyclosome repeat (PC_rep) | Proteasome/cyclosome repeat | - | Repeat |
G [auth S] | PF08375 | Proteasome regulatory subunit C-terminal (Rpn3_C) | Proteasome regulatory subunit C-terminal | - | Family |
G [auth S] | PF01399 | PCI domain (PCI) | PCI domain | This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1]. | Domain |