Annotations: 5L2R

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fumerase	e5l2rA1	A: a+b three layers	X: Thioredoxin-like	H: Fumarate hydratase N-terminal domain (From Topology)	T: Fumarate hydratase N-terminal domain	F: Fumerase	ECOD (1.6)
A	Fumerase_C	e5l2rA3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: FumA C-terminal domain-like (From Topology)	T: FumA C-terminal domain-like	F: Fumerase_C	ECOD (1.6)
B	Fumerase	e5l2rB2	A: a+b three layers	X: Thioredoxin-like	H: Fumarate hydratase N-terminal domain (From Topology)	T: Fumarate hydratase N-terminal domain	F: Fumerase	ECOD (1.6)
B	Fumerase_C	e5l2rB3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: FumA C-terminal domain-like (From Topology)	T: FumA C-terminal domain-like	F: Fumerase_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05683	Fumarase C-terminus (Fumerase_C)	Fumarase C-terminus	-	Family
A, B	PF05681	Fumarate hydratase (Fumerase) (Fumerase)	Fumarate hydratase (Fumerase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Fumarate hydratase	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity hydro-lyase activity lyase activity catalytic activity fumarate hydratase activity carbon-oxygen lyase activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding identical protein binding protein binding binding protein homodimerization activity protein dimerization activity hydro-lyase activity lyase activity catalytic activity fumarate hydratase activity carbon-oxygen lyase activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	organic substance metabolic process oxoacid metabolic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process small molecule metabolic process metabolic process cellular process fumarate metabolic process organic acid metabolic process malate metabolic process generation of precursor metabolites and energy	membrane-bounded organelle intracellular anatomical structure ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection organelle cytoplasm cytosol intracellular organelle peroxisome membrane-bounded organelle intracellular anatomical structure ciliary plasm cilium cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection organelle cytoplasm cytosol intracellular organelle peroxisome microbody glycosome intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011167	Iron-dependent fumarate hydratase	Family
A, B	IPR004646	Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain	Domain
A, B	IPR036660	Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain superfamily	Homologous Superfamily
A, B	IPR004647	Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.