5KNM

Human leukocyte antigen F (HLA-F) presents peptides and regulates immunity through interactions with NK-cell receptors

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8003766	3000071	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8055614	3000071	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054837	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set_2	e5knmA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
A	MHC_I	e5knmA1	A: a+b two layers	X: MHC antigen-recognition domain (From Topology)	H: MHC antigen-recognition domain (From Topology)	T: MHC antigen-recognition domain	F: MHC_I	ECOD (1.6)
B	C1-set_2	e5knmB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
C [auth D]	Ig_2	e5knmD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.500.10	Alpha Beta	2-Layer Sandwich	Murine Class I Major Histocompatibility Complex, H2-DB	Chain A, domain 1	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	MH1 HLA-F*0101	I-ALPHA	Homo sapiens (human)	HLA-F0101, HLA-F0102, HLA-F*0103	G-DOMAIN G-ALPHA1, G-DOMAIN G-ALPHA2, C-LIKE-DOMAIN C-LIKE	MH	MH1-ALPHA_B2M	IMGT (202415-0)
B	MH1 HLA-F*0101	null	Homo sapiens (human)	-	-	MH	MH1-ALPHA_B2M	IMGT (202415-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00129	Class I Histocompatibility antigen, domains alpha 1 and 2 (MHC_I)	Class I Histocompatibility antigen, domains alpha 1 and 2	-	Domain
A	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
B	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
C [auth D]	PF13895	Immunoglobulin domain (Ig_2)	Immunoglobulin domain	This domain contains immunoglobulin-like domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	cDNA FLJ39643 fis, clone SMINT2004023, highly similar to HLA class I histocompatibility antigen, alphachain F	protein binding binding signaling receptor binding antigen binding peptide antigen binding peptide binding TAP1 binding TAP binding 14-3-3 protein binding beta-2-microglobulin binding TAP2 binding	multicellular organismal process regulation of immune effector process lymphocyte mediated immunity positive regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus regulation of natural killer cell cytokine production positive regulation of macromolecule biosynthetic process response to biotic stimulus positive regulation of metabolic process positive regulation of immune response positive regulation of natural killer cell mediated immunity cytokine production organic substance biosynthetic process multicellular organismal process regulation of immune effector process lymphocyte mediated immunity positive regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus regulation of natural killer cell cytokine production positive regulation of macromolecule biosynthetic process response to biotic stimulus positive regulation of metabolic process positive regulation of immune response positive regulation of natural killer cell mediated immunity cytokine production organic substance biosynthetic process leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process natural killer cell mediated immunity positive regulation of immune system process regulation of biological process regulation of natural killer cell mediated immunity regulation of cytokine production involved in immune response immune response response to other organism regulation of innate immune response cellular metabolic process regulation of cellular metabolic process response to external stimulus immune effector process regulation of gene expression regulation of leukocyte mediated immunity biosynthetic process regulation of response to stimulus defense response to other organism positive regulation of defense response positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process regulation of defense response regulation of response to biotic stimulus natural killer cell cytokine production biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of response to stimulus organic substance metabolic process positive regulation of response to external stimulus positive regulation of biosynthetic process response to stress regulation of response to stress regulation of cytokine production innate immune response positive regulation of immune effector process regulation of multicellular organismal process response to external biotic stimulus cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process positive regulation of innate immune response defense response biological regulation defense response to symbiont regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of natural killer cell cytokine production regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of cytokine production involved in immune response cellular process positive regulation of cellular biosynthetic process regulation of localization regulated exocytosis negative regulation of biological process negative regulation of lymphocyte mediated immunity negative regulation of transport cell activation involved in immune response leukocyte degranulation vesicle-mediated transport localization negative regulation of secretion negative regulation of natural killer cell mediated immunity negative regulation of natural killer cell degranulation establishment of localization in cell negative regulation of secretion by cell negative regulation of immune response negative regulation of immune effector process natural killer cell activation leukocyte mediated cytotoxicity establishment of localization regulation of secretion regulation of natural killer cell degranulation exocytosis negative regulation of response to external stimulus natural killer cell degranulation natural killer cell mediated cytotoxicity negative regulation of defense response regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity cellular localization regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus transport lymphocyte activation negative regulation of regulated secretory pathway negative regulation of leukocyte degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell negative regulation of exocytosis natural killer cell activation involved in immune response leukocyte activation involved in immune response negative regulation of cellular process negative regulation of leukocyte mediated cytotoxicity regulation of leukocyte degranulation negative regulation of cell killing lymphocyte activation involved in immune response secretion regulation of transport negative regulation of response to stimulus cell activation regulation of leukocyte mediated cytotoxicity export from cell regulation of vesicle-mediated transport negative regulation of immune system process regulation of exocytosis negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent antigen processing and presentation of peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway positive regulation of leukocyte mediated cytotoxicity positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity positive regulation of cell killing positive regulation of secretion by cell positive regulation of exocytosis positive regulation of secretion positive regulation of transport adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T cell mediated immunity T cell cytokine production negative regulation of cellular metabolic process regulation of T cell mediated immunity negative regulation of cytokine production involved in immune response regulation of adaptive immune response negative regulation of metabolic process negative regulation of adaptive immune response negative regulation of cellular biosynthetic process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of production of molecular mediator of immune response negative regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process negative regulation of T cell mediated immunity negative regulation of T cell cytokine production regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of macromolecule metabolic process negative regulation of cytokine production adaptive immune response negative regulation of biosynthetic process antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of exogenous antigen positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity negative regulation of natural killer cell cytokine production	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex membrane-bounded organelle intracellular anatomical structure cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC class I protein complex MHC protein complex protein-containing complex plasma membrane protein complex membrane protein complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment lumenal side of endoplasmic reticulum membrane intracellular membrane-bounded organelle endomembrane system lumenal side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane MHC class Ib protein complex intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle endosome membrane endosome recycling endosome recycling endosome membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi membrane Golgi apparatus early endosome early endosome membrane extracellular region extracellular space transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
B	Beta-2-microglobulin	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding identical protein binding protein binding protein homodimerization activity protein dimerization activity structural molecule activity	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity regulation of cellular process response to stimulus T cell cytokine production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of immune response cytokine production leukocyte mediated immunity regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of adaptive immune response positive regulation of T cell cytokine production positive regulation of immune system process regulation of T cell mediated immunity regulation of biological process regulation of cytokine production involved in immune response immune response regulation of adaptive immune response regulation of cellular metabolic process immune effector process regulation of gene expression regulation of leukocyte mediated immunity regulation of response to stimulus positive regulation of production of molecular mediator of immune response positive regulation of multicellular organismal process regulation of immune response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response positive regulation of cytokine production regulation of metabolic process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of biological process positive regulation of cellular metabolic process positive regulation of response to stimulus regulation of T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of biosynthetic process regulation of cytokine production positive regulation of immune effector process regulation of multicellular organismal process cytokine production involved in immune response positive regulation of cellular process production of molecular mediator of immune response regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process adaptive immune response regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity positive regulation of gene expression immune system process positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response positive regulation of cellular biosynthetic process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to iron ion cellular response to chemical stimulus response to metal ion response to chemical response to iron ion cellular response to iron(III) ion response to iron(III) ion multicellular organismal-level iron ion homeostasis multicellular organismal-level homeostasis multicellular organismal-level chemical homeostasis regulation of neuron projection development regulation of cellular component organization cellular developmental process cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization system development developmental process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization nervous system development negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization positive regulation of protein binding regulation of binding positive regulation of binding regulation of protein binding positive regulation of molecular function regulation of molecular function regulation of receptor binding regulation of transferrin receptor binding positive regulation of receptor binding positive regulation of transferrin receptor binding regulation of developmental process regulation of cell differentiation regulation of cell development myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class Ib antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent antigen processing and presentation via MHC class Ib antigen processing and presentation of exogenous peptide antigen via MHC class Ib antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation regulation of localization import into cell positive regulation of cellular component organization transport vesicle-mediated transport localization positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of transport endocytosis receptor-mediated endocytosis peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component biogenesis cellular component assembly protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly regulation of neurogenesis regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development negative regulation of multicellular organismal process positive regulation of ferrous iron binding regulation of ferrous iron binding negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of leukocyte mediated cytotoxicity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity regulation of T cell mediated cytotoxicity regulation of cell killing positive regulation of cell killing cell killing iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport metal ion transport system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell amyloid fibril formation supramolecular fiber organization protein homotetramerization protein complex oligomerization protein tetramerization protein homooligomerization antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II negative regulation of receptor binding negative regulation of protein binding negative regulation of binding negative regulation of molecular function peptide antigen assembly with MHC class II protein complex MHC class II protein complex assembly cellular response to nicotine response to nicotine regulation of cellular senescence cellular senescence positive regulation of cellular senescence cellular response to stress response to stress antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I behavior learning or memory cognition regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion positive regulation of leukocyte activation regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of leukocyte cell-cell adhesion regulation of lymphocyte activation negative regulation of forebrain neuron differentiation forebrain development regulation of forebrain neuron differentiation central nervous system neuron differentiation head development forebrain generation of neurons animal organ development brain development central nervous system development forebrain neuron differentiation negative regulation of neuron differentiation regulation of neuron differentiation regulation of monoatomic ion transport regulation of iron ion transport regulation of metal ion transport response to organic substance biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to molecule of bacterial origin response to biotic stimulus	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex HFE-transferrin receptor complex receptor complex intracellular anatomical structure cytoplasm cytosol MHC class I protein complex MHC protein complex endosome membrane endosome intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome organelle membrane phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum Golgi membrane MHC class I peptide loading complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen secretory granule secretory vesicle specific granule anchoring junction cell junction focal adhesion cell-substrate junction MHC class II protein complex early endosome endosome lumen early endosome lumen recycling endosome recycling endosome membrane tertiary granule lumen tertiary granule early endosome membrane transport vesicle transport vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle ER to Golgi transport vesicle membrane coated vesicle
C [auth D]	Leukocyte immunoglobulin-like receptor subfamily B member 1	MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity inhibitory MHC class I receptor activity MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class Ib protein binding protein binding binding signaling receptor binding MHC protein binding protein phosphatase binding MHC class Ib receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity immune receptor activity inhibitory MHC class I receptor activity MHC class I receptor activity HLA-B specific inhibitory MHC class I receptor activity MHC class Ib protein binding protein binding binding signaling receptor binding MHC protein binding protein phosphatase binding phosphatase binding protein phosphatase 1 binding enzyme binding HLA-A specific inhibitory MHC class I receptor activity protein-containing complex binding MHC protein complex binding MHC class Ib protein complex binding SH2 domain binding protein domain specific binding identical protein binding protein homodimerization activity protein dimerization activity MHC class I protein binding	regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process transforming growth factor beta production negative regulation of macromolecule metabolic process regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process transforming growth factor beta production negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process negative regulation of transforming growth factor beta production regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte cell-cell adhesion negative regulation of cell adhesion leukocyte activation cell adhesion cell-cell adhesion T cell activation alpha-beta T cell activation regulation of immune system process regulation of cell-cell adhesion regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation negative regulation of T cell activation negative regulation of immune system process negative regulation of leukocyte cell-cell adhesion immune system process negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of alpha-beta T cell activation negative regulation of leukocyte activation regulation of lymphocyte activation cellular response to stimulus response to organic substance response to stimulus cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction regulation of leukocyte proliferation negative regulation of cell population proliferation cell population proliferation leukocyte proliferation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production tumor necrosis factor superfamily cytokine production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production negative regulation of tumor necrosis factor superfamily cytokine production immune response adaptive immune response localization import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport regulation of immune effector process cell activation involved in immune response positive regulation of cell activation positive regulation of immune response positive regulation of leukocyte activation positive regulation of immune system process positive regulation of gamma-delta T cell activation involved in immune response positive regulation of T cell activation gamma-delta T cell activation immune effector process regulation of response to stimulus regulation of immune response positive regulation of multicellular organismal process gamma-delta T cell activation involved in immune response positive regulation of biological process positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of response to stimulus regulation of gamma-delta T cell activation involved in immune response positive regulation of lymphocyte activation T cell activation involved in immune response leukocyte activation involved in immune response positive regulation of immune effector process lymphocyte activation involved in immune response positive regulation of cellular process regulation of gamma-delta T cell activation positive regulation of cell adhesion positive regulation of gamma-delta T cell activation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death negative regulation of lymphocyte proliferation negative regulation of T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell proliferation negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of immune effector process negative regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response cytokine production involved in immune response production of molecular mediator of immune response regulation of leukocyte differentiation cellular developmental process regulation of developmental process negative regulation of dendritic cell differentiation cell development mononuclear cell differentiation regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation anatomical structure development negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis negative regulation of developmental process regulation of dendritic cell differentiation negative regulation of cell development regulation of hemopoiesis dendritic cell differentiation leukocyte differentiation regulation of localization regulation of calcium ion transport regulation of transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport negative regulation of transport calcium ion transport metal ion transport negative regulation of calcium ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated immunity negative regulation of lymphocyte mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity negative regulation of cell killing regulation of T cell mediated immunity T cell mediated cytotoxicity regulation of adaptive immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity negative regulation of adaptive immune response leukocyte mediated cytotoxicity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity regulation of cell killing negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity cell killing regulation of cellular component organization negative regulation of cellular component organization negative regulation of endocytosis regulation of vesicle-mediated transport cellular component organization cellular component organization or biogenesis regulation of endocytosis regulation of type II interferon production type II interferon production negative regulation of type II interferon production regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus regulation of defense response to virus defense response to virus defense response to other organism response to stress regulation of response to stress positive regulation of defense response to virus by host regulation of defense response to virus by host response to external biotic stimulus response to virus regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response positive regulation of cytokine production positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response myeloid leukocyte cytokine production positive regulation of cytokine production involved in immune response macrophage cytokine production regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway immune response-inhibiting cell surface receptor signaling pathway immune response-regulating signaling pathway immune response-inhibiting signal transduction monoamine transport nitrogen compound transport organic hydroxy compound transport secretion by cell negative regulation of secretion regulation of secretion by cell signal release negative regulation of secretion by cell serotonin secretion negative regulation of serotonin secretion secretion organic substance transport cell-cell signaling export from cell serotonin transport regulation of serotonin secretion regulation of secretion skeletal system development regulation of osteoclast development system development regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation osteoclast development myeloid leukocyte differentiation regulation of osteoclast differentiation osteoclast differentiation bone cell development bone development regulation of myeloid cell differentiation animal organ development negative regulation of osteoclast differentiation negative regulation of osteoclast development myeloid cell differentiation myeloid cell development response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus response to bacterium cellular response to lipid response to molecule of bacterial origin negative regulation of type I interferon production regulation of interferon-beta production interferon-beta production type I interferon production negative regulation of interferon-beta production regulation of type I interferon production negative regulation of interleukin-10 production interleukin-10 production regulation of interleukin-10 production negative regulation of natural killer cell mediated immunity natural killer cell mediated immunity regulation of natural killer cell mediated immunity regulation of innate immune response negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated cytotoxicity negative regulation of response to biotic stimulus innate immune response negative regulation of innate immune response regulation of leukocyte apoptotic process dendritic cell apoptotic process negative regulation of dendritic cell apoptotic process negative regulation of programmed cell death leukocyte apoptotic process negative regulation of apoptotic process negative regulation of leukocyte apoptotic process regulation of dendritic cell apoptotic process T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell regulation of interleukin-12 production negative regulation of interleukin-12 production interleukin-12 production T cell proliferation involved in immune response positive regulation of type II interferon production CD8-positive, alpha-beta T cell activation negative regulation of CD8-positive, alpha-beta T cell activation regulation of CD8-positive, alpha-beta T cell activation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm extracellular region
D [auth N]	Peptide ILE-LEU-ARG-TRP-GLU-GLN	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003597	Immunoglobulin C1-set	Domain
A	IPR011161	MHC class I-like antigen recognition-like	Domain
A	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A	IPR001039	MHC class I alpha chain, alpha1 alpha2 domains	Domain
A	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A	IPR037055	MHC class I-like antigen recognition-like superfamily	Homologous Superfamily
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR003597	Immunoglobulin C1-set	Domain
B	IPR015707	Beta-2-Microglobulin	Family
C [auth D]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C [auth D]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth D]	IPR013151	Immunoglobulin	Domain
C [auth D]	IPR007110	Immunoglobulin-like domain	Domain
C [auth D]	IPR003599	Immunoglobulin subtype	Domain
C [auth D]	IPR003598	Immunoglobulin subtype 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P30511	Crohn disease lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Sjogren syndrome ulcerative colitis astrocytic tumor endogenous depression interstitial cystitis limb-girdle muscular dystrophy malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma Crohn disease lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Sjogren syndrome ulcerative colitis astrocytic tumor endogenous depression interstitial cystitis limb-girdle muscular dystrophy malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma squamous cell lung carcinoma autism spectrum disorder cutaneous lupus erythematosus esophageal adenocarcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant ependymoma nasopharyngeal disease pancreatic ductal adenocarcinoma pemphigus psoriatic arthritis subependymal giant cell astrocytoma cervical cancer dermatomyositis glioblastoma juvenile dermatomyositis lung cancer malignant glioma
B	Pharos: P61769	familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma familial visceral amyloidosis hypoproteinemia, hypercatabolic diffuse large B-cell lymphoma MHC class I deficiency esophageal squamous cell carcinoma kidney disease amyloidosis mature T-cell and NK-cell non-Hodgkin lymphoma autoimmune disease variant ABeta2M amyloidosis Hypergammaglobulinemia prostate cancer heart disease interstitial cystitis lung carcinoma ovarian cancer acquired metabolic disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma psoriasis Sjogren syndrome glioblastoma juvenile dermatomyositis lung adenocarcinoma lymphatic system disease pancreatic intraductal papillary-mucinous carcinoma acute kidney failure periodic fever syndrome bone marrow disease rheumatoid arthritis Down syndrome subependymal giant cell astrocytoma lung cancer lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm cancer schizophrenia ulcerative colitis
C [auth D]	Pharos: Q8NHL6	chronic obstructive pulmonary disease head and neck cancer lung carcinoma non-small cell lung carcinoma peripheral nervous system disease psoriasis subependymal giant cell astrocytoma cutaneous lupus erythematosus interstitial cystitis MALT lymphoma osteosarcoma peripheral neuropathy schizophrenia ulcerative colitis glioblastoma chronic obstructive pulmonary disease head and neck cancer lung carcinoma non-small cell lung carcinoma peripheral nervous system disease psoriasis subependymal giant cell astrocytoma cutaneous lupus erythematosus interstitial cystitis MALT lymphoma osteosarcoma peripheral neuropathy schizophrenia ulcerative colitis glioblastoma large cell medulloblastoma medulloblastoma ovarian cancer pilocytic astrocytoma Sjogren syndrome