Annotations: 5KKP

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TruD_1st	e5kkpA1	A: a+b two layers	X: Alpha-beta plaits	H: Pseudouridine synthase (From Topology)	T: Pseudouridine synthase	F: TruD_1st	ECOD (1.6)
A	R3H	e5kkpA3	A: a+b two layers	X: R3H domain-like	H: R3H domain (From Topology)	T: R3H domain	F: R3H	ECOD (1.6)
A	TruD_2nd	e5kkpA2	A: a+b two layers	X: tRNA pseudouridine synthase TruD insertion domain (From Topology)	H: tRNA pseudouridine synthase TruD insertion domain (From Topology)	T: tRNA pseudouridine synthase TruD insertion domain	F: TruD_2nd	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Pseudouridylate synthase 7	isomerase activity pseudouridine synthase activity catalytic activity intramolecular transferase activity RNA binding binding organic cyclic compound binding nucleic acid binding protein binding enzyme binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process hemopoiesis biological regulation cell development regulation of cell differentiation regulation of hematopoietic stem cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation anatomical structure development hematopoietic stem cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process translation negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process pseudouridine synthesis mRNA modification mRNA metabolic process RNA modification mRNA pseudouridine synthesis macromolecule modification nucleic acid catabolic process regulation of mesoderm development tissue development mesoderm development mRNA processing tRNA processing tRNA pseudouridine synthesis tRNA modification tRNA metabolic process ncRNA metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020103	Pseudouridine synthase, catalytic domain superfamily	Homologous Superfamily
A	IPR001656	Pseudouridine synthase, TruD	Family
A	IPR042214	Pseudouridine synthase, TruD, catalytic domain	Homologous Superfamily
A	IPR020119	Pseudouridine synthase TruD, conserved site	Conserved Site
A	IPR011760	Pseudouridine synthase, TruD, insertion domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96PZ0	bipolar disorder glioblastoma lung cancer medulloblastoma non-small cell lung carcinoma progressive supranuclear palsy diabetes mellitus invasive ductal breast carcinoma malignant colon neoplasm myopathy ovarian cancer exocrine pancreatic carcinoma large cell medulloblastoma malignant pancreatic neoplasm nasopharyngeal carcinoma bipolar disorder glioblastoma lung cancer medulloblastoma non-small cell lung carcinoma progressive supranuclear palsy diabetes mellitus invasive ductal breast carcinoma malignant colon neoplasm myopathy ovarian cancer exocrine pancreatic carcinoma large cell medulloblastoma malignant pancreatic neoplasm nasopharyngeal carcinoma Pick disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.