Annotations: 5KEL

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Virus ectodomain	8039635	3001628	SCOP2B (2022-06-29)
H [auth G]	SCOP2B Superfamily	Virus ectodomain	8039635	3001628	SCOP2B (2022-06-29)
N [auth I]	SCOP2B Superfamily	Virus ectodomain	8039635	3001628	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01611	e5kelA1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: PF01611	ECOD (1.6)
G [auth E]	PF01611	e5kelE1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: PF01611	ECOD (1.6)
M [auth F]	PF01611	e5kelF1	A: a+b complex topology	X: Envelope glycoprotein GP1 (From Topology)	H: Envelope glycoprotein GP1 (From Topology)	T: Envelope glycoprotein GP1	F: PF01611	ECOD (1.6)
B	PF22307	e5kelB1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: PF22307	ECOD (1.6)
H [auth G]	PF22307	e5kelG1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: PF22307	ECOD (1.6)
N [auth I]	PF22307	e5kelI1	A: a+b duplicates or obligate multimers	X: Envelope glycoprotein GP2-related (From Topology)	H: Envelope glycoprotein GP2-related (From Topology)	T: Envelope glycoprotein GP2-related	F: PF22307	ECOD (1.6)
C [auth H]	PF07686	e5kelH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
I [auth P]	PF07686	e5kelP1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
O [auth Q]	PF07686	e5kelQ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth L]	PF07686	e5kelL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
J [auth T]	PF07686	e5kelT1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
P [auth U]	PF07686	e5kelU1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E [auth C]	PF07686	e5kelC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
K [auth J]	PF07686	e5kelJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
Q [auth M]	PF07686	e5kelM1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F [auth D]	PF07686	e5kelD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
L [auth N]	PF07686	e5kelN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
R [auth O]	PF07686	e5kelO1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
C [auth H], I [auth P], O [auth Q]	Fab C13C6	VH	Homo sapiens (human)	IGHV6-602, IGHJ401	V-DOMAIN VH	IG	VH-V-KAPPA	IMGT (202416-0)
D [auth L], J [auth T], P [auth U]	Fab C13C6	V-KAPPA	Homo sapiens (human)	IGKV12-4601, IGKJ201	V-DOMAIN V-KAPPA	IG	VH-V-KAPPA	IMGT (202416-0)
E [auth C], K [auth J], Q [auth M]	Fab C13C6	VH	Homo sapiens (human)	IGHV8-801, IGHJ401	V-DOMAIN VH	IG	FV-HEAVY_KAPPA	IMGT (202416-0)
F [auth D], L [auth N], R [auth O]	Fab C13C6	V-KAPPA	Homo sapiens (human)	IGKV6-1301, IGKJ501	V-DOMAIN V-KAPPA	IG	FV-HEAVY_KAPPA	IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C [auth H], I [auth P], O [auth Q]	Heavy Chain	IGHV6	-	ebola surface glycoprotein, gp2	SAbDab (2024-04-26)
D [auth L], J [auth T], P [auth U]	Light Chain	IGKV12	Kappa	ebola surface glycoprotein, gp2	SAbDab (2024-04-26)
E [auth C], K [auth J], Q [auth M]	Heavy Chain	IGHV8	-	ebola surface glycoprotein, gp1	SAbDab (2024-04-26)
F [auth D], L [auth N], R [auth O]	Light Chain	IGKV6	Kappa	ebola surface glycoprotein, gp1	SAbDab (2024-04-26)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
C [auth H], I [auth P], O [auth Q]	Porgaviximab	Zaire Ebolavirus Glycoprotein	Therapeutic SAbDab (2024-04-26)
D [auth L], J [auth T], P [auth U]	Porgaviximab	Zaire Ebolavirus Glycoprotein	Therapeutic SAbDab (2024-04-26)
E [auth C], K [auth J], Q [auth M]	Cosfroviximab	Zaire Ebolavirus Glycoprotein	Therapeutic SAbDab (2024-04-26)
F [auth D], L [auth N], R [auth O]	Cosfroviximab	Zaire Ebolavirus Glycoprotein	Therapeutic SAbDab (2024-04-26)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, G [auth E], M [auth F]	PF01611	Filovirus glycoprotein (Filo_glycop)	Filovirus glycoprotein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, G [auth E], M [auth F]	Ebola surface glycoprotein, GP1	binding lipid binding identical protein binding protein binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process non-lytic viral release viral budding viral life cycle virion assembly exit from host cell viral budding from plasma membrane viral release from host cell symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host interferon-mediated signaling pathway cellular process symbiont-mediated perturbation of host signal transduction pathway import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	virion component virion membrane extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle viral membrane virion component virion membrane extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle viral membrane viral envelope membrane microdomain membrane raft membrane host cell plasma membrane host cell membrane
B, H [auth G], N [auth I]	Ebola surface glycoprotein, GP2	binding lipid binding identical protein binding protein binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process non-lytic viral release viral budding viral life cycle virion assembly exit from host cell viral budding from plasma membrane viral release from host cell symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host interferon-mediated signaling pathway cellular process symbiont-mediated perturbation of host signal transduction pathway import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell transport of virus virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell entry receptor-mediated virion attachment to host cell adhesion of symbiont to host	virion component virion membrane extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle viral membrane virion component virion membrane extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle viral membrane viral envelope membrane microdomain membrane raft membrane host cell plasma membrane host cell membrane
C [auth H], I [auth P], O [auth Q]	c2G4 variable Fab domain heavy chain	-	-	-
D [auth L], J [auth T], P [auth U]	c2G4 variable Fab domain light chain	-	-	-
E [auth C], K [auth J], Q [auth M]	c13C6 variable Fab domain heavy chain	-	-	-
F [auth D], L [auth N], R [auth O]	c13C6 variable Fab domain light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, G [auth E], M [auth F]	IPR014625	Filoviruses glycoprotein	Family
A, G [auth E], M [auth F]	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain
B, H [auth G], N [auth I]	IPR014625	Filoviruses glycoprotein	Family
B, H [auth G], N [auth I]	IPR002561	Filoviruses glycoprotein, extracellular domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.