5KDI

How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Glycolipid transfer protein GLTP	8089045	4001616	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glycolipid transfer protein GLTP	8089046	3001991	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Glycolipid transfer protein GLTP	8089046	3001991	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08718	e5kdiA1	A: alpha arrays	X: Glycolipid transfer protein, GLTP (From Topology)	H: Glycolipid transfer protein, GLTP (From Topology)	T: Glycolipid transfer protein, GLTP	F: PF08718	ECOD (1.6)
B	PF08718	e5kdiB1	A: alpha arrays	X: Glycolipid transfer protein, GLTP (From Topology)	H: Glycolipid transfer protein, GLTP (From Topology)	T: Glycolipid transfer protein, GLTP	F: PF08718	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3520.10	Mainly Alpha	Orthogonal Bundle	Glycolipid transfer protein, GLTP	Glycolipid transfer protein	CATH (4.3.0)
B	1.10.3520.10	Mainly Alpha	Orthogonal Bundle	Glycolipid transfer protein, GLTP	Glycolipid transfer protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08718	Glycolipid transfer protein (GLTP) (GLTP)	Glycolipid transfer protein (GLTP)	GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids [1][2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Pleckstrin homology domain-containing family A member 8	lipid transporter activity lipid transfer activity transporter activity glycolipid transfer activity phospholipid transfer activity sphingolipid transfer activity sphingolipid transporter activity ceramide transfer activity ceramide 1-phosphate transfer activity phospholipid transporter activity amide binding ceramide binding binding ion binding lipid transporter activity lipid transfer activity transporter activity glycolipid transfer activity phospholipid transfer activity sphingolipid transfer activity sphingolipid transporter activity ceramide transfer activity ceramide 1-phosphate transfer activity phospholipid transporter activity amide binding ceramide binding binding ion binding sphingolipid binding anion binding lipid binding phospholipid binding ceramide 1-phosphate binding small molecule binding phosphatidylinositol phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol binding glycolipid binding carbohydrate derivative binding	membrane organization intermembrane lipid transfer transport organic substance transport lipid localization lipid transport establishment of localization cellular component organization localization macromolecule localization cellular process cellular component organization or biogenesis protein localization establishment of protein localization membrane organization intermembrane lipid transfer transport organic substance transport lipid localization lipid transport establishment of localization cellular component organization localization macromolecule localization cellular process cellular component organization or biogenesis protein localization establishment of protein localization cellular localization nitrogen compound transport protein transport cellular macromolecule localization ER to Golgi ceramide transport intracellular lipid transport intracellular transport ceramide transport amide transport establishment of localization in cell	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cytoplasm Golgi membrane membrane membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle trans-Golgi network cytoplasm Golgi membrane membrane bounding membrane of organelle organelle membrane cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036497	Glycolipid transfer protein superfamily	Homologous Superfamily
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR014830	Glycolipid transfer protein domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96JA3	adrenal cortex carcinoma gastric carcinoma ovarian cancer exocrine pancreatic carcinoma Malignant neoplasm of breast pancreatic intraductal papillary-mucinous neoplasm gastric cancer malignant pancreatic neoplasm psoriasis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				Glycolipid transfer protein

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.