5K6P

The NMR structure of the m domain tri-helix bundle and C2 of human cardiac Myosin Binding Protein C

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054771	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07679	e5k6pA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07679	ECOD (1.6)
A	PF18362	e5k6pA2	A: alpha arrays	X: Myosin-binding motif (m-domain) C-terminal subdomain (From Topology)	H: Myosin-binding motif (m-domain) C-terminal subdomain (From Topology)	T: Myosin-binding motif (m-domain) C-terminal subdomain	F: PF18362	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18362	Tri-helix bundle domain (THB)	Tri-helix bundle domain	This domain can be found in the myosin-binding motif (m-domain) region present in myosin-binding protein C (MyBP-C). MyBP-C is a sarcomeric assembly protein necessary for the regulation of sarcomere structure and function [1]. The MyBP-C family of pr ...	This domain can be found in the myosin-binding motif (m-domain) region present in myosin-binding protein C (MyBP-C). MyBP-C is a sarcomeric assembly protein necessary for the regulation of sarcomere structure and function [1]. The MyBP-C family of proteins consists mainly of modules with immunoglobulin (Ig) or fibronectin folds [2]. This domain exhibits a three-helix bundle fold and there is a known actin-binding motif, LK(R/K)XK positioned in the third helix (alpha3), similar to that found in villin and related proteins [1].	Domain
A	PF07679	Immunoglobulin I-set domain (I-set)	Immunoglobulin I-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Myosin-binding protein C, cardiac-type	cytoskeletal protein binding titin binding protein binding binding structural molecule activity structural constituent of muscle ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity myosin heavy chain binding myosin binding actin binding cation binding cytoskeletal protein binding titin binding protein binding binding structural molecule activity structural constituent of muscle ATPase activator activity molecular function activator activity molecular function regulator activity ATPase regulator activity myosin heavy chain binding myosin binding actin binding cation binding ion binding metal ion binding small molecule binding identical protein binding	developmental process heart development multicellular organismal process heart morphogenesis animal organ development circulatory system development multicellular organism development anatomical structure morphogenesis anatomical structure development animal organ morphogenesis system development system process regulation of biological process regulation of system process developmental process heart development multicellular organismal process heart morphogenesis animal organ development circulatory system development multicellular organism development anatomical structure morphogenesis anatomical structure development animal organ morphogenesis system development system process regulation of biological process regulation of system process biological regulation muscle contraction regulation of muscle system process muscle system process striated muscle contraction regulation of striated muscle contraction regulation of muscle contraction regulation of multicellular organismal process cell adhesion cellular process heart process circulatory system process cardiac muscle contraction heart contraction blood circulation ventricular cardiac muscle tissue morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development cardiac chamber development muscle tissue development muscle organ development cardiac chamber morphogenesis cardiac muscle tissue development tissue development muscle tissue morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity regulation of localization cellular localization regulation of cellular process regulation of actin filament-based process transport muscle filament sliding localization establishment of localization in cell actin filament-based process regulation of intracellular transport actin-myosin filament sliding regulation of transport intracellular transport actin filament-based movement establishment of localization regulation of cellular localization regulation of actin filament-based movement regulation of muscle filament sliding actin-mediated cell contraction	intracellular anatomical structure myofilament myosin filament cellular anatomical entity sarcomere intracellular organelle striated muscle myosin thick filament organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber cytoplasm supramolecular polymer supramolecular complex intracellular anatomical structure myofilament myosin filament cellular anatomical entity sarcomere intracellular organelle striated muscle myosin thick filament organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber cytoplasm supramolecular polymer supramolecular complex myofibril non-membrane-bounded organelle A band C zone cytosol cardiac myofibril

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR040849	MyBP-C, tri-helix bundle domain	Domain
A	IPR013098	Immunoglobulin I-set	Domain
A	IPR003961	Fibronectin type III	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14896	hypertrophic cardiomyopathy 4 left ventricular noncompaction 10 cardiomyopathy hypertrophic cardiomyopathy left ventricular noncompaction dilated cardiomyopathy Cardiomegaly hypertensive disorder sudden cardiac arrest endogenous depression familial isolated dilated cardiomyopathy metabolic syndrome X open-angle glaucoma cerebrovascular disorder dilated cardiomyopathy 1A hypertrophic cardiomyopathy 4 left ventricular noncompaction 10 cardiomyopathy hypertrophic cardiomyopathy left ventricular noncompaction dilated cardiomyopathy Cardiomegaly hypertensive disorder sudden cardiac arrest endogenous depression familial isolated dilated cardiomyopathy metabolic syndrome X open-angle glaucoma cerebrovascular disorder dilated cardiomyopathy 1A familial dilated cardiomyopathy heart disease hypertrophic cardiomyopathy 1 prostate carcinoma Charcot-Marie-Tooth disease familial hypertrophic cardiomyopathy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.