Annotations: 5K5S

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Metabotropic glutamate receptor ligand-binding domain-like	8078808	4007730	SCOP2 (2022-06-29)
B	SCOP2 Family	Glutamate receptor cysteine-rich domain-like	8049714	4006602	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Type 1 solute binding protein-like	8078809	3000125	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	TNF receptor-like	8091102	3000971	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Type 1 solute binding protein-like	8078809	3000125	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	TNF receptor-like	8091102	3000971	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	ANF_receptor_2nd	e5k5sB3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd	ECOD (1.6)
B	ANF_receptor_2nd_1	e5k5sB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd_1	ECOD (1.6)
B	NCD3G	e5k5sB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: NCD3G	ECOD (1.6)
A	ANF_receptor_2nd	e5k5sA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd	ECOD (1.6)
A	ANF_receptor_2nd_1	e5k5sA3	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Periplasmic binding protein-like I	F: ANF_receptor_2nd_1	ECOD (1.6)
A	NCD3G	e5k5sA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: NCD3G	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)
A	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01094	Receptor family ligand binding region (ANF_receptor)	Receptor family ligand binding region	-	Family
A, B	PF07562	Nine Cysteines Domain of family 3 GPCR (NCD3G)	Nine Cysteines Domain of family 3 GPCR	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Extracellular calcium-sensing receptor	binding amino acid binding identical protein binding protein binding cation binding ion binding calcium ion binding metal ion binding small molecule binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity phosphoric ester hydrolase activity binding amino acid binding identical protein binding protein binding cation binding ion binding calcium ion binding metal ion binding small molecule binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phosphatidylinositol phospholipase C activity phospholipase activity lipase activity transmembrane transporter binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding	regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization metal ion transport calcium ion transport localization monoatomic ion transport regulation of metal ion transport monoatomic cation transport regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization metal ion transport calcium ion transport localization monoatomic ion transport regulation of metal ion transport monoatomic cation transport developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium regulation of tube diameter system process regulation of tube size regulation of system process positive regulation of biological process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size monoatomic ion transmembrane transport inorganic ion transmembrane transport inorganic anion transmembrane transport chloride transport transmembrane transport chloride transmembrane transport monoatomic anion transport monoatomic anion transmembrane transport cellular process inorganic anion transport regulation of cellular process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process response to stimulus response to stress response to ischemia response to decreased oxygen levels cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis bile acid secretion organic anion transport carboxylic acid transport secretion organic substance transport acid secretion organic acid transport monocarboxylic acid transport response to peptide response to organic substance cellular response to peptide behavior chemosensory behavior signaling intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade signal transduction response to endogenous stimulus response to organonitrogen compound response to lipoprotein particle response to nitrogen compound cellular response to low-density lipoprotein particle stimulus cellular response to lipoprotein particle stimulus phospholipase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of calcium ion import positive regulation of calcium ion transport positive regulation of calcium ion import positive regulation of transport positive regulation of monoatomic ion transport calcium ion import ossification connective tissue development adipose tissue development fat pad development animal organ development response to fibroblast growth factor response to growth factor positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus response to glucose glucose homeostasis response to nutrient levels response to lipid response to nutrient cellular response to organic cyclic compound response to vitamin cellular response to vitamin D cellular response to nutrient levels response to vitamin D cellular response to vitamin cellular response to lipid cellular response to nutrient response to organic cyclic compound cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation vasodilation positive chemotaxis chemotaxis positive regulation of locomotion regulation of response to external stimulus positive regulation of positive chemotaxis response to external stimulus regulation of chemotaxis positive regulation of chemotaxis regulation of positive chemotaxis positive regulation of response to external stimulus taxis regulation of locomotion locomotion adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to endogenous stimulus response to hepatocyte growth factor cellular response to growth factor stimulus cellular response to hepatocyte growth factor stimulus protein localization establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization cellular macromolecule localization positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion positive regulation of protein localization cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell regulation of protein transport positive regulation of protein secretion peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion detection of stimulus response to metal ion detection of chemical stimulus detection of calcium ion response to calcium ion response to inorganic substance	cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region cellular anatomical entity basolateral plasma membrane somatodendritic compartment cell body neuronal cell body apical part of cell apical plasma membrane cell surface cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region cellular anatomical entity basolateral plasma membrane somatodendritic compartment cell body neuronal cell body apical part of cell apical plasma membrane cell surface axon synapse neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon cell junction neuron projection terminus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017978	GPCR family 3, C-terminal	Domain
A, B	IPR017979	GPCR, family 3, conserved site	Conserved Site
A, B	IPR000068	GPCR, family 3, extracellular calcium-sensing receptor-related	Family
A, B	IPR028082	Periplasmic binding protein-like I	Homologous Superfamily
A, B	IPR001828	Receptor, ligand binding region	Domain
A, B	IPR000337	GPCR, family 3	Family
A, B	IPR038550	GPCR, family 3, nine cysteines domain superfamily	Homologous Superfamily
A, B	IPR011500	GPCR, family 3, nine cysteines domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P41180	hypercalcemia disease hyperparathyroidism hypoparathyroidism neonatal severe primary hyperparathyroidism autosomal dominant hypocalcemia Hypocalcemia familial hypocalciuric hypercalcemia 1 epilepsy, idiopathic generalized, susceptibility to, 8 familial hypoparathyroidism nephrolithiasis autosomal dominant hypocalcemia 1 psoriasis hypoparathyroidism, familial isolated 1 intellectual disability acne hypercalcemia disease hyperparathyroidism hypoparathyroidism neonatal severe primary hyperparathyroidism autosomal dominant hypocalcemia Hypocalcemia familial hypocalciuric hypercalcemia 1 epilepsy, idiopathic generalized, susceptibility to, 8 familial hypoparathyroidism nephrolithiasis autosomal dominant hypocalcemia 1 psoriasis hypoparathyroidism, familial isolated 1 intellectual disability acne osteosarcoma Bartter syndrome with hypocalcemia secondary hyperparathyroidism hyperphosphatemia lung carcinoma pancreatitis EIG1 primary hyperparathyroidism familial hypocalciuric hypercalcemia Sjogren syndrome Hashimoto thyroiditis osteogenesis imperfecta epilepsy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.