5K1A

Crystal structure of the UAF1-USP12 complex in C2 space group

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
G	PF00443	e5k1aG1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00443	ECOD (1.6)
A	PF00443	e5k1aA1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00443	ECOD (1.6)
C	PF00443	e5k1aC1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00443	ECOD (1.6)
E	PF00443	e5k1aE1	A: a+b complex topology	X: Cysteine proteinases-like	H: Cysteine proteinases (From Topology)	T: Cysteine proteinases	F: PF00443	ECOD (1.6)
D	PF00400	e5k1aD2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
D	F_UNCLASSIFIED	e5k1aD4	A: beta duplicates or obligate multimers	X: WD repeat-containing protein 48 ancillary domain (From Topology)	H: WD repeat-containing protein 48 ancillary domain (From Topology)	T: WD repeat-containing protein 48 ancillary domain	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF11816	e5k1aD3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF11816	ECOD (1.6)
H	PF00400	e5k1aH2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
H	F_UNCLASSIFIED	e5k1aH4	A: beta duplicates or obligate multimers	X: WD repeat-containing protein 48 ancillary domain (From Topology)	H: WD repeat-containing protein 48 ancillary domain (From Topology)	T: WD repeat-containing protein 48 ancillary domain	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF11816	e5k1aH3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF11816	ECOD (1.6)
B	PF00400	e5k1aB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
B	F_UNCLASSIFIED	e5k1aB4	A: beta duplicates or obligate multimers	X: WD repeat-containing protein 48 ancillary domain (From Topology)	H: WD repeat-containing protein 48 ancillary domain (From Topology)	T: WD repeat-containing protein 48 ancillary domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF11816	e5k1aB3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF11816	ECOD (1.6)
F	PF00400	e5k1aF2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
F	F_UNCLASSIFIED	e5k1aF4	A: beta duplicates or obligate multimers	X: WD repeat-containing protein 48 ancillary domain (From Topology)	H: WD repeat-containing protein 48 ancillary domain (From Topology)	T: WD repeat-containing protein 48 ancillary domain	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF11816	e5k1aF3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF11816	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00443	Ubiquitin carboxyl-terminal hydrolase (UCH)	Ubiquitin carboxyl-terminal hydrolase	-	Family
B, D, F, H	PF11816	Domain of unknown function (DUF3337) (DUF3337)	Domain of unknown function (DUF3337)	-	Family
B, D, F, H	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Ubiquitin carboxyl-terminal hydrolase 12	cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity cysteine-type endopeptidase activity endopeptidase activity cation binding ion binding binding metal ion binding cysteine-type peptidase activity ubiquitin-like protein peptidase activity peptidase activity cysteine-type deubiquitinase activity catalytic activity, acting on a protein hydrolase activity catalytic activity deubiquitinase activity cysteine-type endopeptidase activity endopeptidase activity cation binding ion binding binding metal ion binding small molecule binding	protein deubiquitination organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein modification by small protein removal macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation or removal proteolysis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B, D, F, H	WD repeat-containing protein 48	protein binding binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding double-stranded DNA binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity protein binding binding ubiquitin binding ubiquitin-like protein binding DNA binding organic cyclic compound binding nucleic acid binding double-stranded DNA binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity single-stranded DNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organismal process reproductive system development gonad development tube development reproductive process sex differentiation animal organ development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organismal process reproductive system development gonad development tube development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics seminiferous tubule development anatomical structure development reproductive structure development system development spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells skin development fertilization single fertilization regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation positive regulation of epithelial cell proliferation biological regulation positive regulation of biological process regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of cellular process embryonic organ development embryo development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process organic substance metabolic process positive regulation of DNA repair regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination organic cyclic compound metabolic process positive regulation of DNA metabolic process regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction signaling positive regulation of receptor signaling pathway via STAT regulation of signal transduction positive regulation of receptor signaling pathway via JAK-STAT cell communication regulation of receptor signaling pathway via JAK-STAT signal transduction regulation of signaling cell surface receptor signaling pathway regulation of cell communication regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling anatomical structure morphogenesis skeletal system development skeletal system morphogenesis animal organ morphogenesis regulation of protein modification process regulation of protein ubiquitination protein ubiquitination protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process protein monoubiquitination macromolecule modification regulation of protein monoubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal multicellular organism growth developmental growth growth	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen lytic vacuole vacuole lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle late endosome vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR028889	Ubiquitin specific protease domain	Domain
A, C, E, G	IPR018200	Ubiquitin specific protease, conserved site	Conserved Site
A, C, E, G	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Domain
A, C, E, G	IPR038765	Papain-like cysteine peptidase superfamily	Homologous Superfamily
B, D, F, H	IPR019775	WD40 repeat, conserved site	Conserved Site
B, D, F, H	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B, D, F, H	IPR021772	WDR48/Bun107	Family
B, D, F, H	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B, D, F, H	IPR001680	WD40 repeat	Repeat
B, D, F, H	IPR020472	G-protein beta WD-40 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: O75317	astrocytic tumor juvenile dermatomyositis malignant glioma ovarian cancer atypical teratoid rhabdoid tumor large cell medulloblastoma medulloblastoma primitive neuroectodermal tumor glioblastoma malignant ependymoma osteosarcoma
B, D, F, H	Pharos: Q8TAF3	malignant mesothelioma osteosarcoma Spastic Paraplegia, Hereditary medulloblastoma ovarian cancer metabolic syndrome X psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.