5JY4

A high magnesium structure of the isochorismate synthase, EntC

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00425	e5jy4A1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: PF00425	ECOD (1.6)
B	PF00425	e5jy4B1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: PF00425	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)
B	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00425	chorismate binding enzyme (Chorismate_bind)	chorismate binding enzyme	-	Family
B	PF00425	chorismate binding enzyme (Chorismate_bind)	chorismate binding enzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Isochorismate synthase EntC	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding isomerase activity isochorismate synthase activity intramolecular hydroxytransferase activity catalytic activity intramolecular transferase activity	enterobactin biosynthetic process polyketide metabolic process organic hydroxy compound metabolic process catechol-containing compound metabolic process secondary metabolic process antibiotic biosynthetic process siderophore biosynthetic process antibiotic metabolic process organic substance metabolic process secondary metabolite biosynthetic process siderophore metabolic process lactone biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process enterobactin biosynthetic process polyketide metabolic process organic hydroxy compound metabolic process catechol-containing compound metabolic process secondary metabolic process antibiotic biosynthetic process siderophore biosynthetic process antibiotic metabolic process organic substance metabolic process secondary metabolite biosynthetic process siderophore metabolic process lactone biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process catechol-containing siderophore biosynthetic process enterobactin metabolic process macrolide biosynthetic process macrolide metabolic process organic cyclic compound metabolic process biosynthetic process peptide biosynthetic process polyketide biosynthetic process lactone metabolic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process phenol-containing compound biosynthetic process metabolic process nonribosomal peptide biosynthetic process peptide metabolic process	-
B	Isochorismate synthase EntC	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding isomerase activity isochorismate synthase activity intramolecular hydroxytransferase activity catalytic activity intramolecular transferase activity	enterobactin biosynthetic process polyketide metabolic process organic hydroxy compound metabolic process catechol-containing compound metabolic process secondary metabolic process antibiotic biosynthetic process siderophore biosynthetic process antibiotic metabolic process organic substance metabolic process secondary metabolite biosynthetic process siderophore metabolic process lactone biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process enterobactin biosynthetic process polyketide metabolic process organic hydroxy compound metabolic process catechol-containing compound metabolic process secondary metabolic process antibiotic biosynthetic process siderophore biosynthetic process antibiotic metabolic process organic substance metabolic process secondary metabolite biosynthetic process siderophore metabolic process lactone biosynthetic process organic substance biosynthetic process catechol-containing compound biosynthetic process catechol-containing siderophore biosynthetic process enterobactin metabolic process macrolide biosynthetic process macrolide metabolic process organic cyclic compound metabolic process biosynthetic process peptide biosynthetic process polyketide biosynthetic process lactone metabolic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process phenol-containing compound biosynthetic process metabolic process nonribosomal peptide biosynthetic process peptide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain
A	IPR004561	Isochorismate synthase	Family
A	IPR005801	ADC synthase	Homologous Superfamily
B	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain
B	IPR004561	Isochorismate synthase	Family
B	IPR005801	ADC synthase	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	CSO	Parent Component: CYS RESID: AA0205 PSI-MOD : L-cysteine sulfenic acid MOD:00210

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.