Annotations: 5JXC

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SynGAP coiled-coil domain	8103619	3002792	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SynGAP coiled-coil domain	8103619	3002792	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SynGAP coiled-coil domain	8103619	3002792	SCOP2B (2022-06-29)
D	SCOP2 Family	SynGAP coiled-coil domain	8047093	4005445	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	SynGAP coiled-coil domain	8103619	3002792	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	SynGAP coiled-coil domain	8103619	3002792	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SynGAP coiled-coil domain	8103619	3002792	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF12004	Disabled homolog 2-interacting protein, C-terminal domain (DAB2P_C)	Disabled homolog 2-interacting protein, C-terminal domain	This domain is found at the C terminus of some GTPase-activating proteins (also known as GAP) found in animals, including Disabled homolog 2-interacting protein (DAB2P). This region is found associated with Pfam:PF00616 and Pfam:PF00168, and includes ...	This domain is found at the C terminus of some GTPase-activating proteins (also known as GAP) found in animals, including Disabled homolog 2-interacting protein (DAB2P). This region is found associated with Pfam:PF00616 and Pfam:PF00168, and includes a coiled-coil domain that forms a parallel trimer in solution with one helical strand from each monomer [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Ras/Rap GTPase-activating protein SynGAP	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity SH3 domain binding protein binding binding protein domain specific binding kinase binding enzyme binding protein kinase binding	biological regulation regulation of synapse structure or activity regulation of biological quality developmental process multicellular organism development multicellular organismal process anatomical structure development pattern specification process cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling biological regulation regulation of synapse structure or activity regulation of biological quality developmental process multicellular organism development multicellular organismal process anatomical structure development pattern specification process cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process response to stimulus signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette MAPK cascade regulation of cell communication cellular process signal transduction small GTPase-mediated signal transduction negative regulation of signaling regulation of small GTPase mediated signal transduction negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of cell communication regulation of Ras protein signal transduction negative regulation of cellular process negative regulation of response to stimulus Ras protein signal transduction negative regulation of small GTPase mediated signal transduction negative regulation of signal transduction negative regulation of Ras protein signal transduction response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis system development plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of long-term neuronal synaptic plasticity modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling dendrite development regulation of cell differentiation regulation of neurogenesis regulation of cell development negative regulation of cellular component organization regulation of cell projection organization negative regulation of axonogenesis negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization regulation of developmental process regulation of nervous system development negative regulation of neurogenesis regulation of axonogenesis negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of multicellular organismal development negative regulation of developmental process negative regulation of neuron projection development negative regulation of cell development regulation of plasma membrane bounded cell projection organization protein localization localization cellular localization receptor clustering cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane maintenance of synapse structure postsynapse organization cellular component maintenance cell junction maintenance organelle organization cell junction organization maintenance of postsynaptic specialization structure postsynaptic density organization synapse organization postsynaptic specialization organization	membrane cellular anatomical entity cell periphery plasma membrane synapse cell junction glutamatergic synapse somatodendritic compartment cell projection dendrite dendritic tree neuron projection dendritic shaft plasma membrane bounded cell projection membrane cellular anatomical entity cell periphery plasma membrane synapse cell junction glutamatergic synapse somatodendritic compartment cell projection dendrite dendritic tree neuron projection dendritic shaft plasma membrane bounded cell projection postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle asymmetric synapse postsynaptic density, intracellular component intracellular anatomical structure postsynaptic specialization, intracellular component intracellular organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR001849	Pleckstrin homology domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR021887	Disabled homolog 2-interacting protein, C-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR000008	C2 domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR039360	Ras GTPase-activating protein	Family
A, B, C, D, E A, B, C, D, E, F	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001936	Ras GTPase-activating domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR023152	Ras GTPase-activating protein, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR037779	SynGAP, PH domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR035892	C2 domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.