Annotations: 5JW7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pentapeptide_4	e5jw7A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Pentapeptide repeats (From Topology)	T: Pentapeptide repeats	F: Pentapeptide_4	ECOD (1.6)
A	SopA_C	e5jw7A2	A: a+b complex topology	X: E3 ubiquitin-protein ligase SopA catalytic domain (From Topology)	H: E3 ubiquitin-protein ligase SopA catalytic domain (From Topology)	T: E3 ubiquitin-protein ligase SopA catalytic domain	F: SopA_C	ECOD (1.6)
B	zf-C3HC4_4	e5jw7B1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: zf-C3HC4_4	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13981	SopA-like central domain (SopA)	SopA-like central domain	This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes.	Domain
B	PF13445	RING-type zinc-finger (zf-RING_UBOX)	RING-type zinc-finger	This zinc-finger is a typical RING-type of plant ubiquitin ligases [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	E3 ubiquitin-protein ligase SopA	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity	organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	host cellular component host cell cellular anatomical entity extracellular region
B	E3 ubiquitin-protein ligase TRIM56	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding ubiquitin-like protein ligase activity ubiquitin protein ligase activity	response to organic substance biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to chemical immune system process defense response to other organism response to stress innate immune response response to organic substance biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response response to cytokine defense response to symbiont response to external stimulus response to biotic stimulus response to chemical immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus response to type I interferon organonitrogen compound metabolic process protein polyubiquitination primary metabolic process protein K63-linked ubiquitination organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal multicellular organismal process regulation of cellular process cellular biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of multicellular organismal process regulation of biosynthetic process regulation of biological process type I interferon production cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process cellular process regulation of macromolecule biosynthetic process regulation of metabolic process regulation of type I interferon production cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of non-canonical NF-kappaB signal transduction positive regulation of signaling regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus regulation of response to external stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress regulation of immune system process positive regulation of immune system process positive regulation of innate immune response regulation of innate immune response positive regulation of defense response regulation of immune response protein monoubiquitination defense response to virus response to virus regulation of type I interferon-mediated signaling pathway interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of response to cytokine stimulus positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to organic substance cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus type I interferon-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of interferon-beta production positive regulation of cytokine production positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR025726	E3 ubiquitin ligase SopA-like central domain	Domain
A	IPR038270	SopA-like, catalytic domain superfamily	Homologous Superfamily
A	IPR025725	E3 ubiquitin-protein ligase SopA-like, catalytic domain	Domain
B	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
B	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
B	IPR047153	TRIM45/56/19	Family
B	IPR000315	B-box-type zinc finger	Domain
B	IPR027370	Zinc finger, RING-type, eukaryotic	Domain
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q9BRZ2	subependymal giant cell astrocytoma astrocytic tumor cystic fibrosis glioblastoma juvenile dermatomyositis malignant ependymoma myopathy pancreatic ductal adenocarcinoma attention deficit hyperactivity disorder, inattentive type gastric cancer hepatocellular carcinoma large cell medulloblastoma malignant glioma osteosarcoma pilocytic astrocytoma subependymal giant cell astrocytoma astrocytic tumor cystic fibrosis glioblastoma juvenile dermatomyositis malignant ependymoma myopathy pancreatic ductal adenocarcinoma attention deficit hyperactivity disorder, inattentive type gastric cancer hepatocellular carcinoma large cell medulloblastoma malignant glioma osteosarcoma pilocytic astrocytoma chronic kidney disease gastric carcinoma invasive ductal breast carcinoma lung cancer medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.