Annotations: 5JVM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5jvma1	All alpha proteins	EB1 dimerisation domain-like	EB1 dimerisation domain-like	EB1 dimerisation domain-like	Microtubule-associated protein EB1, C-terminal dimerization domain	Mouse (Mus musculus ) [TaxId: 10090 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5jvma2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Mouse (Mus musculus ) [TaxId: 10090 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5jvmb1	All alpha proteins	EB1 dimerisation domain-like	EB1 dimerisation domain-like	EB1 dimerisation domain-like	Microtubule-associated protein EB1, C-terminal dimerization domain	Mouse (Mus musculus ) [TaxId: 10090 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5jvmb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Mouse (Mus musculus ) [TaxId: 10090 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03271	e5jvmA1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)
B	PF03271	e5jvmB1	A: alpha duplicates or obligate multimers	X: EB1 dimerisation domain-like (From Topology)	H: EB1 dimerisation domain-like (From Topology)	T: EB1 dimerisation domain-like	F: PF03271	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
B	1.20.5.1430	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03271	EB1-like C-terminal motif (EB1)	EB1-like C-terminal motif	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Chimera protein of Kinesin-like protein KIF3C and Microtubule-associated protein RP/EB family member 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding microtubule binding protein binding tubulin binding kinesin binding microtubule motor activity cytoskeletal motor activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding nucleic acid binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding molecular adaptor activity microtubule plus-end binding identical protein binding	microtubule-based movement microtubule-based process cellular process regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization microtubule-based movement microtubule-based process cellular process regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization microtubule bundle formation organelle organization microtubule cytoskeleton organization cytoskeleton organization protein localization localization cellular localization cellular macromolecule localization macromolecule localization protein localization to microtubule cytoskeleton protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle protein localization to centrosome regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization negative regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly microtubule polymerization or depolymerization negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization negative regulation of supramolecular fiber organization protein polymerization negative regulation of cellular component organization negative regulation of microtubule polymerization or depolymerization protein-containing complex organization negative regulation of cytoskeleton organization regulation of microtubule-based process negative regulation of microtubule polymerization microtubule polymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly negative regulation of organelle organization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of microtubule cytoskeleton organization establishment of organelle localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation cell cycle chromosome segregation cell cycle process mitotic nuclear division attachment of spindle microtubules to kinetochore organelle fission attachment of mitotic spindle microtubules to kinetochore chromosome organization sister chromatid segregation establishment of localization nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization cell division cell migration cell motility organelle assembly non-membrane-bounded organelle assembly spindle assembly spindle organization plasma membrane bounded cell projection assembly cilium assembly non-motile cilium assembly cilium organization cell projection assembly protein localization to astral microtubule protein localization to microtubule protein localization to cytoplasmic microtubule protein localization to spindle microtubule spindle localization establishment or maintenance of cell polarity establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation microtubule cytoskeleton organization involved in mitosis establishment of cell polarity establishment of mitotic spindle orientation positive regulation of organelle organization positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of microtubule polymerization or depolymerization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization positive regulation of microtubule polymerization	neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cellular anatomical entity cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle polymeric cytoskeletal fiber microtubule end cytoskeleton supramolecular fiber microtubule supramolecular polymer microtubule plus-end microtubule cytoskeleton cytosol protein-containing complex microtubule associated complex kinesin complex somatodendritic compartment cell body neuronal cell body axon dendrite dendritic tree growth cone distal axon site of polarized growth membrane-bounded organelle transport vesicle synapse intracellular vesicle intracellular membrane-bounded organelle endomembrane system presynapse cytoplasmic vesicle synaptic vesicle cell junction secretory vesicle vesicle exocytic vesicle anchoring junction focal adhesion cell-substrate junction spindle spindle midzone centrosome microtubule organizing center mitotic spindle aster spindle microtubule cytoplasmic microtubule mitotic spindle astral microtubule end mitotic spindle astral microtubule astral microtubule cell periphery membrane plasma membrane plasma membrane region cell projection membrane Golgi apparatus cell cortex cortical cytoskeleton cortical microtubule cytoskeleton mitotic spindle pole spindle pole cilium ciliary basal body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR001752	Kinesin motor domain	Domain
A, B	IPR027640	Kinesin-like protein	Family
A, B	IPR019821	Kinesin motor domain, conserved site	Conserved Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR001715	Calponin homology domain	Domain
A, B	IPR004953	EB1, C-terminal	Domain
A, B	IPR027328	Microtubule-associated protein RP/EB	Family
A, B	IPR036133	EB1, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR036872	CH domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q15691	Weight Gain primitive neuroectodermal tumor astrocytic tumor coronary artery disease inflammatory bowel disease lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor dermatomyositis juvenile dermatomyositis malignant ependymoma myocardial ischemia osteosarcoma Weight Gain primitive neuroectodermal tumor astrocytic tumor coronary artery disease inflammatory bowel disease lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma plasma cell myeloma atypical teratoid rhabdoid tumor dermatomyositis juvenile dermatomyositis malignant ependymoma myocardial ischemia osteosarcoma polycystic ovary syndrome breast carcinoma glioblastoma large cell medulloblastoma malignant glioma nicotine dependence ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.