5JTI

Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 2

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07647	e5jtiA1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF07647	ECOD (1.6)
B	PF07647	e5jtiB1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF07647	ECOD (1.6)
C	PF07647	e5jtiC1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF07647	ECOD (1.6)
D	PF07647	e5jtiD1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF07647	ECOD (1.6)
E	PF07647	e5jtiE1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF07647	ECOD (1.6)
F	PF07647	e5jtiF1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: PF07647	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
C	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
E	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
F	1.10.150.50	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF07647	SAM domain (Sterile alpha motif) (SAM_2)	SAM domain (Sterile alpha motif)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Tankyrase-1	NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity protein binding binding histone binding catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity protein binding binding histone binding catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups	regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion, telomeric negative regulation of maintenance of sister chromatid cohesion regulation of cellular component organization regulation of cellular process negative regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, telomeric negative regulation of biological process negative regulation of cell cycle maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion, telomeric cellular component organization negative regulation of sister chromatid cohesion negative regulation of chromosome organization regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion, telomeric negative regulation of maintenance of sister chromatid cohesion regulation of cellular component organization regulation of cellular process negative regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, telomeric negative regulation of biological process negative regulation of cell cycle maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion, telomeric cellular component organization negative regulation of sister chromatid cohesion negative regulation of chromosome organization maintenance of mitotic sister chromatid cohesion negative regulation of cellular process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process regulation of biological process negative regulation of cellular component organization regulation of cell cycle process biological regulation chromosome organization sister chromatid cohesion regulation of chromosome organization negative regulation of cell cycle process regulation of organelle organization negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric regulation of maintenance of sister chromatid cohesion organelle organization negative regulation of organelle organization regulation of sister chromatid cohesion cellular process RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport regulation of telomere maintenance cellular biosynthetic process telomere organization regulation of DNA biosynthetic process regulation of primary metabolic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process telomere maintenance via telomerase cellular metabolic process primary metabolic process regulation of cellular metabolic process DNA metabolic process regulation of macromolecule metabolic process regulation of telomere maintenance via telomere lengthening nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase telomere maintenance regulation of cellular biosynthetic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process regulation of DNA metabolic process cell division protein localization establishment of protein localization cellular localization protein transport cellular macromolecule localization regulation of molecular function regulation of DNA binding regulation of binding negative regulation of binding negative regulation of molecular function negative regulation of telomeric DNA binding regulation of telomeric DNA binding negative regulation of DNA binding organonitrogen compound metabolic process protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation organelle assembly non-membrane-bounded organelle assembly microtubule cytoskeleton organization spindle assembly cellular component biogenesis cellular component assembly microtubule-based process cytoskeleton organization chromosome segregation spindle organization protein polyubiquitination protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of catalytic activity regulation of transferase activity positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA metabolic process regulation of telomerase activity positive regulation of biological process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of biosynthetic process positive regulation of cellular process positive regulation of telomerase activity positive regulation of transferase activity positive regulation of catalytic activity positive regulation of DNA biosynthetic process positive regulation of cellular biosynthetic process positive regulation of organelle organization positive regulation of telomere maintenance via telomere lengthening positive regulation of telomere maintenance positive regulation of chromosome organization positive regulation of telomere maintenance via telomerase positive regulation of cellular component organization peptidyl-serine modification peptidyl-serine phosphorylation protein localization to chromosome protein localization to organelle protein localization to chromosome, telomeric region mitotic cell cycle mitotic spindle organization mitotic cell cycle process microtubule cytoskeleton organization involved in mitosis negative regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of DNA metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction Wnt signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein poly-ADP-ribosylation positive regulation of telomere capping telomere capping regulation of telomere capping DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process regulation of RNA biosynthetic process gene expression positive regulation of RNA biosynthetic process protein auto-ADP-ribosylation	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol protein-containing complex nuclear protein-containing complex nuclear pore membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Golgi apparatus Golgi membrane bounding membrane of organelle pericentriolar material centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle mitotic spindle spindle mitotic spindle pole spindle pole nuclear body chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR002110	Ankyrin repeat	Repeat
A, B, C, D, E A, B, C, D, E, F	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: O95271	ovarian cancer Carcinoma in situ of fallopian tube dermatomyositis psoriasis epilepsy osteosarcoma Sjogren syndrome

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.