Annotations: 5JOJ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5joja_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_1	e5jojA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00036	EF hand (EF-hand_1)	EF hand	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typica ...	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Plastin-2	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding enzyme binding GTPase binding cell adhesion molecule binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding enzyme binding GTPase binding cell adhesion molecule binding integrin binding signaling receptor binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication protein kinase A signaling cellular process signal transduction cellular component organization cellular component disassembly extracellular matrix disassembly cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication protein kinase A signaling cellular process signal transduction cellular component organization cellular component disassembly extracellular matrix disassembly extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization cell migration cell motility protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport localization cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of transport organic substance transport regulation of establishment of protein localization intracellular transport regulation of protein transport establishment of localization protein transport regulation of cellular localization macromolecule localization regulation of intracellular protein transport intracellular protein transport organelle organization actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process cytoskeleton organization actin filament organization actin crosslink formation supramolecular fiber organization actin filament network formation positive regulation of organelle organization positive regulation of cellular component organization regulation of cellular component organization non-membrane-bounded organelle assembly positive regulation of biological process positive regulation of podosome assembly cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly regulation of podosome assembly protein-containing complex assembly positive regulation of cellular process organelle assembly podosome assembly positive regulation of cellular component biogenesis protein-containing complex organization regulation of cellular component biogenesis regulation of organelle organization regulation of organelle assembly positive regulation of organelle assembly developmental process animal organ regeneration animal organ development anatomical structure development regeneration multicellular organismal process immune response cell activation lymphocyte activation cell activation involved in immune response leukocyte activation immune effector process T cell activation involved in immune response T cell activation immune system process leukocyte activation involved in immune response lymphocyte activation involved in immune response actin filament bundle organization actin filament bundle assembly	cell junction cellular anatomical entity anchoring junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane cell junction cellular anatomical entity anchoring junction focal adhesion cell-substrate junction ruffle cell leading edge plasma membrane membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol glial cell projection actin filament bundle perinuclear region of cytoplasm polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex phagocytic cup actin-based cell projection filopodium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001715	Calponin homology domain	Domain
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A	IPR036872	CH domain superfamily	Homologous Superfamily
A	IPR039959	Fimbrin/Plastin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P13796	Liver Cirrhosis, Experimental nicotine dependence diabetes mellitus interstitial cystitis lung carcinoma non-small cell lung carcinoma glioblastoma Sjogren syndrome ulcerative colitis IgA glomerulonephritis lung cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.