5JBT

Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5jbta_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Trypsin(ogen)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8036274	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00089	e5jbtA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
C [auth Y]	PF00014	e5jbtY1	A: few secondary structure elements	X: BPTI-like (From Topology)	H: BPTI-like (From Topology)	T: BPTI-like	F: PF00014	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
B [auth X]	PF00014	Kunitz/Bovine pancreatic trypsin inhibitor domain (Kunitz_BPTI)	Kunitz/Bovine pancreatic trypsin inhibitor domain	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the ...	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, Swiss:P17726). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways [1]. TAP molecules are highly dipolar [2], and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix [1].	Domain
C [auth Y]	PF00014	Kunitz/Bovine pancreatic trypsin inhibitor domain (Kunitz_BPTI)	Kunitz/Bovine pancreatic trypsin inhibitor domain	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the ...	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP, Swiss:P17726). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways [1]. TAP molecules are highly dipolar [2], and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PRSS3 protein	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to other organism response to stress immune system process response to external biotic stimulus humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to other organism response to stress immune system process response to external biotic stimulus epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cellular process cell motility organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process zymogen activation cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process organic substance biosynthetic process protein processing digestion	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region extracellular space
B [auth X]	Amyloid-like protein 2	cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding identical protein binding protein binding	developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation G protein-coupled receptor signaling pathway signal transduction cell communication	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane intracellular anatomical structure membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane intracellular anatomical structure platelet alpha granule membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle cytoplasm organelle membrane platelet alpha granule secretory granule membrane membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum nucleus
C [auth Y]	Amyloid-like protein 2	cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity cation binding transition metal ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding identical protein binding protein binding	developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation G protein-coupled receptor signaling pathway signal transduction cell communication	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane intracellular anatomical structure membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery plasma membrane intracellular anatomical structure platelet alpha granule membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle cytoplasm organelle membrane platelet alpha granule secretory granule membrane membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
B [auth X]	IPR019744	Amyloidogenic glycoprotein, copper-binding domain conserved site	Conserved Site
B [auth X]	IPR019745	Amyloidogenic glycoprotein, intracellular domain, conserved site	Conserved Site
B [auth X]	IPR011178	Amyloidogenic glycoprotein, copper-binding	Domain
B [auth X]	IPR002223	Pancreatic trypsin inhibitor Kunitz domain	Domain
B [auth X]	IPR008154	Amyloidogenic glycoprotein, extracellular	Domain
B [auth X]	IPR015849	Amyloidogenic glycoprotein, heparin-binding	Domain
B [auth X]	IPR011993	PH-like domain superfamily	Homologous Superfamily
B [auth X]	IPR019543	Beta-amyloid precursor protein C-terminal	Domain
B [auth X]	IPR036176	E2 domain superfamily	Homologous Superfamily
B [auth X]	IPR036454	Amyloidogenic glycoprotein, heparin-binding domain superfamily	Homologous Superfamily
B [auth X]	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site	Conserved Site
B [auth X]	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	Homologous Superfamily
B [auth X]	IPR024329	Amyloidogenic glycoprotein, E2 domain	Domain
B [auth X]	IPR036669	Amyloidogenic glycoprotein, copper-binding domain superfamily	Homologous Superfamily
B [auth X]	IPR008155	Amyloidogenic glycoprotein	Family
C [auth Y]	IPR019744	Amyloidogenic glycoprotein, copper-binding domain conserved site	Conserved Site
C [auth Y]	IPR019745	Amyloidogenic glycoprotein, intracellular domain, conserved site	Conserved Site
C [auth Y]	IPR011178	Amyloidogenic glycoprotein, copper-binding	Domain
C [auth Y]	IPR002223	Pancreatic trypsin inhibitor Kunitz domain	Domain
C [auth Y]	IPR008154	Amyloidogenic glycoprotein, extracellular	Domain
C [auth Y]	IPR015849	Amyloidogenic glycoprotein, heparin-binding	Domain
C [auth Y]	IPR011993	PH-like domain superfamily	Homologous Superfamily
C [auth Y]	IPR019543	Beta-amyloid precursor protein C-terminal	Domain
C [auth Y]	IPR036176	E2 domain superfamily	Homologous Superfamily
C [auth Y]	IPR036454	Amyloidogenic glycoprotein, heparin-binding domain superfamily	Homologous Superfamily
C [auth Y]	IPR020901	Proteinase inhibitor I2, Kunitz, conserved site	Conserved Site
C [auth Y]	IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	Homologous Superfamily
C [auth Y]	IPR024329	Amyloidogenic glycoprotein, E2 domain	Domain
C [auth Y]	IPR036669	Amyloidogenic glycoprotein, copper-binding domain superfamily	Homologous Superfamily
C [auth Y]	IPR008155	Amyloidogenic glycoprotein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P35030	urinary bladder cancer primitive neuroectodermal tumor astrocytic tumor diabetes mellitus large cell medulloblastoma malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm Prevention of deep vein thrombosis psoriasis urinary bladder neoplasm atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma malignant pancreatic neoplasm urinary bladder cancer primitive neuroectodermal tumor astrocytic tumor diabetes mellitus large cell medulloblastoma malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm Prevention of deep vein thrombosis psoriasis urinary bladder neoplasm atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma cystic fibrosis Hashimoto thyroiditis malignant glioma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma
B [auth X]	Pharos: Q06481	Nerve Degeneration pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor Duchenne muscular dystrophy gastric carcinoma lung cancer medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma coronary artery disease Emery-Dreifuss muscular dystrophy large cell medulloblastoma lymphoplasmacytic lymphoma myocardial ischemia ovarian cancer Nerve Degeneration pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor Duchenne muscular dystrophy gastric carcinoma lung cancer medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma coronary artery disease Emery-Dreifuss muscular dystrophy large cell medulloblastoma lymphoplasmacytic lymphoma myocardial ischemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis cystic fibrosis gastric cancer lung adenocarcinoma malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma
C [auth Y]	Pharos: Q06481	Nerve Degeneration pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor Duchenne muscular dystrophy gastric carcinoma lung cancer medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma coronary artery disease Emery-Dreifuss muscular dystrophy large cell medulloblastoma lymphoplasmacytic lymphoma myocardial ischemia ovarian cancer Nerve Degeneration pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor Duchenne muscular dystrophy gastric carcinoma lung cancer medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma coronary artery disease Emery-Dreifuss muscular dystrophy large cell medulloblastoma lymphoplasmacytic lymphoma myocardial ischemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis cystic fibrosis gastric cancer lung adenocarcinoma malignant pancreatic neoplasm myopathy pancreatic ductal adenocarcinoma