Annotations: 5IWZ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF18584	e5iwzA2	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PF18584	ECOD (1.6)
A	PF18581	e5iwzA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF18581	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF18584	Synaptonemal complex 2 Spt16M-like domain (SYCP2_SLD)	Synaptonemal complex 2 Spt16M-like domain	Synaptonemal complex protein 2 (SYCP2) N-terminal region contains two separate subdomains an ARLD (armadillo-repeat-like domain) and an SLD (Spt16M-like domain). The SLD structure is highly similar to the middle domain of the histone chaperone FA ...	Synaptonemal complex protein 2 (SYCP2) N-terminal region contains two separate subdomains an ARLD (armadillo-repeat-like domain) and an SLD (Spt16M-like domain). The SLD structure is highly similar to the middle domain of the histone chaperone FACT. It consists of a twisted ten-stranded beta-sheet flanked by two helices. Since the SLD domain structurally resembles Spt16M, which is known as the well-recognized histone protein H2A-H2B; it is speculated that the SLD may be involved in chromatin binding [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Synaptonemal complex protein 2	DNA binding binding organic cyclic compound binding nucleic acid binding	regulation of biological process negative regulation of reproductive process regulation of reproductive process reproductive process biological regulation negative regulation of biological process developmental process anatomical structure morphogenesis animal organ development anatomical structure development animal organ morphogenesis sexual reproduction fertilization cellular process regulation of biological process negative regulation of reproductive process regulation of reproductive process reproductive process biological regulation negative regulation of biological process developmental process anatomical structure morphogenesis animal organ development anatomical structure development animal organ morphogenesis sexual reproduction fertilization cellular process cell division cellular developmental process cell development developmental process involved in reproduction cell death programmed cell death involved in cell development cell differentiation ectopic germ cell programmed cell death programmed cell death regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process organelle fission meiotic cell cycle multicellular organismal reproductive process female gamete generation meiotic cell cycle process gamete generation cellular component organization nuclear division organelle organization female meiotic nuclear division meiotic nuclear division cellular component organization or biogenesis cell cycle cell cycle process male meiotic nuclear division male gamete generation male genitalia morphogenesis genitalia development multicellular organismal process reproductive system development male anatomical structure morphogenesis sex differentiation male sex differentiation multicellular organism development reproductive structure development male genitalia development genitalia morphogenesis system development regulation of developmental process negative regulation of developmental process	membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle membrane-bounded organelle condensed nuclear chromosome intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle synaptonemal structure synaptonemal complex condensed chromosome non-membrane-bounded organelle nuclear lumen lateral element nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR040560	Synaptonemal complex protein 2, Spt16M-like domain	Domain
A	IPR024835	Synaptonemal complex protein 2-like	Family
A	IPR041322	Synaptonemal complex protein 2, armadillo-repeat-like domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.