5ISA
Crystal structure of mouse CARM1 in complex with inhibitor SA0401
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A [auth C] | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
A [auth C] | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
B [auth D] | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
B [auth D] | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
C [auth A] | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
C [auth A] | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
D [auth B] | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
D [auth B] | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth C] | PF22528 | e5isaC2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PF22528 | ECOD (1.6) |
A [auth C] | PF06325 | e5isaC1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PF06325 | ECOD (1.6) |
B [auth D] | PF22528 | e5isaD1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PF22528 | ECOD (1.6) |
B [auth D] | PF06325 | e5isaD2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PF06325 | ECOD (1.6) |
C [auth A] | PF22528 | e5isaA2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PF22528 | ECOD (1.6) |
C [auth A] | PF06325 | e5isaA1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PF06325 | ECOD (1.6) |
D [auth B] | PF22528 | e5isaB1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PF22528 | ECOD (1.6) |
D [auth B] | PF06325 | e5isaB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PF06325 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth C], B [auth D], C [auth A], D [auth B] | PF11531 | Coactivator-associated arginine methyltransferase 1 N terminal (CARM1) | Coactivator-associated arginine methyltransferase 1 N terminal | CARM1 is an arginine methyltransferase which methylates a variety of different proteins and plays a role in gene expression. This is the N terminal domain of the protein which has a PH domain, normally present to regulate protein-protein interactions ... | Domain |
A [auth C], B [auth D], C [auth A], D [auth B] | PF06325 | Ribosomal protein L11 methyltransferase (PrmA) (PrmA) | Ribosomal protein L11 methyltransferase (PrmA) | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth C], B [auth D], C [auth A], D [auth B] | IPR020989 | Histone-arginine methyltransferase CARM1, N-terminal | Domain |
A [auth C], B [auth D], C [auth A], D [auth B] | IPR011993 | PH-like domain superfamily | Homologous Superfamily |
A [auth C], B [auth D], C [auth A], D [auth B] | IPR025799 | Protein arginine N-methyltransferase | Family |
A [auth C], B [auth D], C [auth A], D [auth B] | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Homologous Superfamily |