Annotations: 5IRM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13516	e5irmA5	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13516	ECOD (1.6)
A	PF17779	e5irmA3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF17779	ECOD (1.6)
A	F_UNCLASSIFIED	e5irmA2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF17776	e5irmA4	A: alpha superhelices	X: NLRC4 helical domain HD2 (From Topology)	H: NLRC4 helical domain HD2 (From Topology)	T: NLRC4 helical domain HD2	F: PF17776	ECOD (1.6)
A	PF05729	e5irmA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF05729	ECOD (1.6)
B [auth C]	PF13516	e5irmC5	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13516	ECOD (1.6)
B [auth C]	PF17779	e5irmC3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF17779	ECOD (1.6)
B [auth C]	F_UNCLASSIFIED	e5irmC2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth C]	PF17776	e5irmC1	A: alpha superhelices	X: NLRC4 helical domain HD2 (From Topology)	H: NLRC4 helical domain HD2 (From Topology)	T: NLRC4 helical domain HD2	F: PF17776	ECOD (1.6)
B [auth C]	PF05729	e5irmC4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF05729	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C]	PF05729	NACHT domain (NACHT)	NACHT domain	This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation [1]. This family is closely related to Pfam:PF00931.	Domain
A, B [auth C]	PF13516	Leucine Rich repeat (LRR_6)	Leucine Rich repeat	-	Repeat
A, B [auth C]	PF17776	NLRC4 helical domain HD2 (NLRC4_HD2)	NLRC4 helical domain HD2	This entry represents a helical domain found in the NLRC4 protein [2] and NOD2 protein [1].	Domain
A, B [auth C]	PF17779	NOD2 winged helix domain (NOD2_WH)	NOD2 winged helix domain	This winged helix domain is found in the NOD2 protein [1]. Its molecular function is not known.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C]	Uncharacterized protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding protein-containing complex binding muramyl dipeptide binding amide binding organic acid binding carboxylic acid binding monocarboxylic acid binding Hsp90 protein binding protein binding heat shock protein binding glycosaminoglycan binding peptidoglycan binding Hsp70 protein binding protein-folding chaperone binding ubiquitin binding ubiquitin-like protein binding molecular transducer activity pattern recognition receptor activity signaling receptor activity kinase binding enzyme binding protein kinase binding cytoskeletal protein binding actin binding CARD domain binding protein domain specific binding	multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process multicellular organismal process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression regulation of interleukin-18 production negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of interleukin-18 production negative regulation of multicellular organismal process regulation of metabolic process interleukin-18 production regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production tumor necrosis factor superfamily cytokine production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production negative regulation of tumor necrosis factor superfamily cytokine production response to stimulus immune response immune system process adaptive immune response negative regulation of interleukin-2 production regulation of interleukin-2 production interleukin-2 production localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport biological process involved in interspecies interaction between organisms detection of external biotic stimulus response to other organism response to external stimulus detection of biotic stimulus detection of bacterium response to biotic stimulus detection of stimulus response to bacterium detection of other organism response to external biotic stimulus regulation of localization positive regulation of cellular component organization regulation of cellular component organization positive regulation of biological process cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport cellular response to stimulus regulation of cell motility regulation of response to external stimulus neutrophil chemotaxis regulation of granulocyte chemotaxis taxis regulation of cell migration myeloid leukocyte migration cell migration regulation of immune system process cell motility locomotion cell chemotaxis chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration regulation of chemotaxis neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus regulation of response to stimulus response to chemical regulation of locomotion granulocyte chemotaxis regulation of neutrophil chemotaxis leukocyte chemotaxis regulation of neutrophil migration multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells intestinal stem cell homeostasis defense response defense response to bacterium defense response to other organism response to stress catabolic process macroautophagy autophagy xenophagy cellular catabolic process process utilizing autophagic mechanism interleukin-1 production positive regulation of cellular metabolic process regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of interleukin-1 beta production positive regulation of biosynthetic process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of interleukin-1 production interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway pattern recognition receptor signaling pathway regulation of signal transduction cell communication immune response-activating signaling pathway negative regulation of toll-like receptor 2 signaling pathway positive regulation of immune response signal transduction positive regulation of immune system process cell surface toll-like receptor signaling pathway innate immune response-activating signaling pathway immune response-activating cell surface receptor signaling pathway regulation of innate immune response regulation of toll-like receptor 2 signaling pathway regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus negative regulation of signaling signaling innate immune response activating cell surface receptor signaling pathway negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response toll-like receptor 2 signaling pathway cell surface pattern recognition receptor signaling pathway regulation of signaling positive regulation of innate immune response cell surface receptor signaling pathway negative regulation of response to stimulus defense response to symbiont negative regulation of signal transduction negative regulation of immune system process regulation of cell communication cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of xenophagy regulation of autophagy positive regulation of macroautophagy positive regulation of autophagy regulation of xenophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production positive regulation of cell communication positive regulation of signal transduction intracellular signal transduction positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade positive regulation of signaling interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production negative regulation of inflammatory response inflammatory response to antigenic stimulus negative regulation of inflammatory response to antigenic stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus regulation of inflammatory response negative regulation of response to external stimulus negative regulation of defense response inflammatory response regulation of immune effector process negative regulation of macrophage cytokine production negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of immune effector process immune effector process negative regulation of production of molecular mediator of immune response regulation of macrophage cytokine production regulation of production of molecular mediator of immune response myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response macrophage cytokine production regulation of type II interferon production type II interferon production negative regulation of type II interferon production modulation by host of symbiont process host-mediated regulation of intestinal microbiota composition biological process involved in interaction with symbiont biological process involved in symbiotic interaction positive regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process positive regulation of cytokine production involved in immune response regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell activation positive regulation of leukocyte activation B cell activation cell activation positive regulation of B cell activation regulation of lymphocyte activation antibacterial peptide production regulation of humoral immune response regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of antimicrobial peptide biosynthetic process positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria defense response to Gram-positive bacterium regulation of antimicrobial peptide biosynthetic process peptide biosynthetic process antibacterial peptide biosynthetic process peptide metabolic process humoral immune response regulation of antibacterial peptide production antimicrobial humoral response positive regulation of defense response to bacterium positive regulation of antimicrobial peptide production positive regulation of humoral immune response antimicrobial peptide production regulation of defense response to bacterium regulation of antimicrobial humoral response antibacterial humoral response biosynthetic process of antibacterial peptides active against Gram-positive bacteria positive regulation of antimicrobial humoral response regulation of antimicrobial peptide production antimicrobial peptide biosynthetic process positive regulation of antibacterial peptide production regulation of antibacterial peptide biosynthetic process regulation of protein modification process positive regulation of protein metabolic process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process protein K63-linked ubiquitination regulation of protein K63-linked ubiquitination positive regulation of protein modification process protein ubiquitination protein metabolic process protein modification process regulation of protein modification by small protein conjugation or removal positive regulation of protein K63-linked ubiquitination positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of protein polyubiquitination organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process protein polyubiquitination primary metabolic process positive regulation of protein polyubiquitination macromolecule modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal response to organic substance detection of peptidoglycan response to organonitrogen compound response to oxygen-containing compound response to muramyl dipeptide response to nitrogen compound detection of molecule of bacterial origin detection of chemical stimulus detection of muramyl dipeptide response to molecule of bacterial origin response to peptidoglycan nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process cellular response to stress response to endoplasmic reticulum stress maintenance of gastrointestinal epithelium system process digestion epithelial structure maintenance digestive system process anatomical structure homeostasis tissue homeostasis leukocyte apoptotic process regulation of programmed cell death macrophage apoptotic process negative regulation of leukocyte apoptotic process myeloid cell apoptotic process regulation of leukocyte apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of macrophage apoptotic process cell death negative regulation of apoptotic process regulation of macrophage apoptotic process inflammatory cell apoptotic process negative regulation of myeloid cell apoptotic process apoptotic process regulation of myeloid cell apoptotic process programmed cell death positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction cellular response to nitrogen compound cellular response to biotic stimulus cellular response to endogenous stimulus cellular response to organic substance response to endogenous stimulus cellular response to peptidoglycan cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to organonitrogen compound positive regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production response to dsRNA response to exogenous dsRNA response to organic cyclic compound adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity positive regulation of leukocyte mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of B cell mediated immunity humoral immune response mediated by circulating immunoglobulin regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response leukocyte mediated immunity positive regulation of adaptive immune response positive regulation of immunoglobulin mediated immune response positive regulation of humoral immune response mediated by circulating immunoglobulin regulation of adaptive immune response immunoglobulin mediated immune response regulation of B cell mediated immunity regulation of leukocyte mediated immunity regulation of lymphocyte mediated immunity B cell mediated immunity response to lipid cellular response to lipopolysaccharide response to lipopolysaccharide cellular response to lipid positive regulation of type 2 immune response type 2 immune response regulation of type 2 immune response cell population proliferation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production regulation of monocyte chemotactic protein-1 production positive regulation of monocyte chemotactic protein-1 production monocyte chemotactic protein-1 production regulation of chemokine production chemokine production positive regulation of chemokine production cellular response to muramyl dipeptide cellular localization establishment of localization in cell regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process innate immune response in mucosa mucosal immune response organ or tissue specific immune response regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production response to nutrient levels regulation of biological quality regulation of appetite temperature homeostasis regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response negative regulation of interleukin-12 production regulation of dendritic cell antigen processing and presentation positive regulation of dendritic cell antigen processing and presentation positive regulation of antigen processing and presentation antigen processing and presentation regulation of antigen processing and presentation dendritic cell antigen processing and presentation positive regulation of organelle organization positive regulation of autophagy of mitochondrion mitophagy organelle disassembly regulation of autophagy of mitochondrion mitochondrion organization cellular component disassembly positive regulation of mitophagy regulation of mitophagy regulation of organelle organization organelle organization regulation of mitochondrion organization autophagy of mitochondrion Notch signaling pathway regulation of Notch signaling pathway positive regulation of Notch signaling pathway positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production positive regulation of phosphorylation regulation of protein phosphorylation peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation antibacterial innate immune response T cell mediated immunity negative regulation of lymphocyte mediated immunity regulation of T cell mediated immunity negative regulation of adaptive immune response negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane membrane-bounded organelle intracellular organelle Golgi apparatus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle extrinsic component of plasma membrane extrinsic component of membrane mitochondrion cell surface intracellular vesicle phagocytic vesicle cytoplasmic vesicle vesicle endocytic vesicle protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B [auth C]	IPR001611	Leucine-rich repeat	Repeat
A, B [auth C]	IPR041075	NOD2, winged helix domain	Domain
A, B [auth C]	IPR007111	NACHT nucleoside triphosphatase	Domain
A, B [auth C]	IPR011029	Death-like domain superfamily	Homologous Superfamily
A, B [auth C]	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2	Domain
A, B [auth C]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B [auth C]	IPR001315	CARD domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.