5IO9

X-RAY STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN DOUBLECORTIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5io9a1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Doublecortin (DC)	Doublecortin (DC)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5io9a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5io9b_	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Doublecortin (DC)	Doublecortin (DC)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Doublecortin (DC)	8032858	3000670	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Doublecortin (DC)	8032858	3000670	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DCX	e5io9A1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: DCX	ECOD (1.6)
B	DCX	e5io9B1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: DCX	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.230	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Doublecortin domain	CATH (4.3.0)
B	3.10.20.230	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Doublecortin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03607	Doublecortin (DCX)	Doublecortin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Neuronal migration protein doublecortin	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding kinase binding enzyme binding protein kinase binding	developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development sensory organ development eye development animal organ development retina development in camera-type eye visual system development camera-type eye development sensory system development developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development sensory organ development eye development animal organ development retina development in camera-type eye visual system development camera-type eye development sensory system development neuron migration cellular developmental process generation of neurons neurogenesis cell differentiation cellular process cell migration cell motility cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction intracellular signal transduction cell communication organelle assembly plasma membrane bounded cell projection organization cell projection organization microtubule cytoskeleton organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis microtubule bundle formation organelle organization cellular component assembly cilium assembly microtubule-based process cellular component organization or biogenesis axoneme assembly cytoskeleton organization cilium organization cell projection assembly	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol protein-containing complex microtubule associated complex microtubule cytoskeleton polymeric cytoskeletal fiber supramolecular fiber intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol protein-containing complex microtubule associated complex microtubule cytoskeleton polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex cell projection neuron projection plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003533	Doublecortin domain	Domain
A, B	IPR049626	DCX/DCDC2-like	Family
A, B	IPR017302	Neuronal migration protein doublecortin, chordates	Family
A, B	IPR036572	Doublecortin domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O43602	subcortical band heterotopia lissencephaly spectrum disorders lissencephaly type 1 due to doublecortin gene mutation Miller-Dieker lissencephaly syndrome oligodendroglioma pituitary cancer arthrogryposis cerebrovascular disorder Classical Lissencephaly intellectual disability lung carcinoma medulloblastoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor subcortical band heterotopia lissencephaly spectrum disorders lissencephaly type 1 due to doublecortin gene mutation Miller-Dieker lissencephaly syndrome oligodendroglioma pituitary cancer arthrogryposis cerebrovascular disorder Classical Lissencephaly intellectual disability lung carcinoma medulloblastoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor chromosome 17p13.1 deletion syndrome epilepsy invasive ductal breast carcinoma Pick disease progressive supranuclear palsy breast cancer malignant ependymoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.