Annotations: 5IL6

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PS-DH_N	e5il6A2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_N	ECOD (1.6)
A	PS-DH_C	e5il6A1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_C	ECOD (1.6)
B	PS-DH_N	e5il6B1	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_N	ECOD (1.6)
B	PS-DH_C	e5il6B2	A: a+b two layers	X: Thioesterase/thiol ester dehydrase-isomerase-like	H: Thioesterase/thiol ester dehydrase-isomerase (From Topology)	T: Thioesterase/thiol ester dehydrase-isomerase	F: PS-DH_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21089	Polyketide synthase dehydratase domain (PKS_DH_N)	Polyketide synthase dehydratase domain	This domain is part of a dehydratase domain found in diverse PKS enzymes. This domain adopts a HotDog fold.	Domain
A, B	PF14765	Polyketide synthase dehydratase N-terminal domain (PS-DH)	Polyketide synthase dehydratase N-terminal domain	This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and ...	This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Polyketide synthase/nonribosomal peptide synthetase hybrid RzxB	oxidoreductase activity catalytic activity vitamin binding amide binding modified amino acid binding binding phosphopantetheine binding small molecule binding acyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity ligase activity	organic substance metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process biosynthetic process polyketide metabolic process organic substance biosynthetic process metabolic process secondary metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process organic substance metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process biosynthetic process polyketide metabolic process organic substance biosynthetic process metabolic process secondary metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process cellular lipid metabolic process small molecule metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process peptide biosynthetic process nonribosomal peptide biosynthetic process peptide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR014031	Beta-ketoacyl synthase, C-terminal	Domain
A, B	IPR006162	Phosphopantetheine attachment site	PTM
A, B	IPR013217	Methyltransferase type 12	Domain
A, B	IPR020807	Polyketide synthase, dehydratase domain	Domain
A, B	IPR014030	Beta-ketoacyl synthase, N-terminal	Domain
A, B	IPR049552	Polyketide synthase, dehydratase domain, N-terminal	Domain
A, B	IPR049551	Polyketide synthase, dehydratase domain, C-terminal	Domain
A, B	IPR020845	AMP-binding, conserved site	Conserved Site
A, B	IPR013968	Polyketide synthase, ketoreductase domain	Domain
A, B	IPR020806	Polyketide synthase, phosphopantetheine-binding domain	Domain
A, B	IPR020841	Polyketide synthase, beta-ketoacyl synthase domain	Domain
A, B	IPR036736	ACP-like superfamily	Homologous Superfamily
A, B	IPR025110	AMP-binding enzyme, C-terminal domain	Domain
A, B	IPR032821	Polyketide synthase, C-terminal extension	Domain
A, B	IPR009081	Phosphopantetheine binding ACP domain	Domain
A, B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A, B	IPR010071	Amino acid adenylation domain	Domain
A, B	IPR016039	Thiolase-like	Homologous Superfamily
A, B	IPR045851	AMP-binding enzyme, C-terminal domain superfamily	Homologous Superfamily
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR018201	Beta-ketoacyl synthase, active site	Active Site
A, B	IPR000415	Nitroreductase-like	Homologous Superfamily
A, B	IPR000873	AMP-dependent synthetase/ligase domain	Domain
A, B	IPR042104	Polyketide synthase, dehydratase domain superfamily	Homologous Superfamily