Annotations: 5IKJ

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Clr2 C-terminal domain-like	8046108	4004882	SCOP2 (2022-06-29)
A	SCOP2 Family	Clr2 N-terminal domain-like	8044783	4004131	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Tudor/PWWP/MBT domain-like	8052683	3000404	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Tudor/PWWP/MBT domain-like	8052684	3000404	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Clr2 N-terminal domain-like	8052681	3002135	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF10383	e5ikjA3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF10383	ECOD (1.6)
A	F_UNCLASSIFIED	e5ikjA2	A: beta barrels	X: SH3	H: Chromo domain-like (From Topology)	T: Chromo domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF16761	e5ikjA1	A: a+b three layers	X: Cryptic loci regulator 2 N-terminal domain (From Topology)	H: Cryptic loci regulator 2 N-terminal domain (From Topology)	T: Cryptic loci regulator 2 N-terminal domain	F: PF16761	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16761	Transcription-silencing protein, cryptic loci regulator Clr2 (Clr2_transil)	Transcription-silencing protein, cryptic loci regulator Clr2	-	Family
A	PF10383	Transcription-silencing protein Clr2 (Clr2)	Transcription-silencing protein Clr2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cryptic loci regulator 2	-	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	protein-containing complex intracellular anatomical structure CENP-A containing chromatin protein-DNA complex chromosome chromatin cellular anatomical entity chromosomal region intracellular organelle chromosome, centromeric core domain organelle intracellular non-membrane-bounded organelle chromosome, centromeric region non-membrane-bounded organelle protein-containing complex intracellular anatomical structure CENP-A containing chromatin protein-DNA complex chromosome chromatin cellular anatomical entity chromosomal region intracellular organelle chromosome, centromeric core domain organelle intracellular non-membrane-bounded organelle chromosome, centromeric region non-membrane-bounded organelle heterochromatin rDNA heterochromatin mating-type region heterochromatin membrane-bounded organelle ATPase complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex SHREC complex intracellular organelle lumen histone deacetylase complex nucleoplasm NuRD complex SWI/SNF superfamily-type complex catalytic complex intracellular membrane-bounded organelle organelle lumen CHD-type complex nuclear lumen chromosome, subtelomeric region chromosome, telomeric region pericentric heterochromatin
B	Cryptic loci regulator protein 1	cation binding ion binding binding metal ion binding small molecule binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process protein-DNA complex organization cellular component organization organic substance metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle rDNA heterochromatin organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle mating-type region heterochromatin membrane-bounded organelle protein-containing complex intracellular anatomical structure protein-DNA complex chromatin chromosome cellular anatomical entity heterochromatin intracellular organelle rDNA heterochromatin organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle mating-type region heterochromatin membrane-bounded organelle ATPase complex nucleus membrane-enclosed lumen nuclear protein-containing complex transcription regulator complex SHREC complex intracellular organelle lumen histone deacetylase complex nucleoplasm NuRD complex SWI/SNF superfamily-type complex catalytic complex intracellular membrane-bounded organelle organelle lumen CHD-type complex nuclear lumen chromosome, subtelomeric region chromosome, telomeric region chromosomal region pericentric heterochromatin chromosome, centromeric region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038986	Cryptic loci regulator 2	Family
A	IPR018839	Cryptic loci regulator 2, C-terminal	Domain
A	IPR031915	Cryptic loci regulator 2, N-terminal	Domain
B	IPR013087	Zinc finger C2H2-type	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.