Annotations: 5IJL

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DNA polymerase II DP2 subunit-like	8044970	4004231	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Two-barrel nucleic acid polymerases	8055689	3001330	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Two-barrel nucleic acid polymerases	8055690	3001330	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PolC_DP2_6th	e5ijlA4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PolC_DP2_6th	ECOD (1.6)
A	PolC_DP2_2nd	e5ijlA5	A: beta barrels	X: cradle loop barrel	H: DP2 DPBB-1 domain (From Topology)	T: DP2 DPBB-1 domain	F: PolC_DP2_2nd	ECOD (1.6)
A	PolC_DP2_3rd	e5ijlA6	A: alpha arrays	X: HTH	H: DNA polymerase II large subunit DP2 helical domain (From Topology)	T: DNA polymerase II large subunit DP2 helical domain	F: PolC_DP2_3rd	ECOD (1.6)
A	PolC_DP2_4th	e5ijlA7	A: a+b two layers	X: Homing endonucleases-like	H: DNA polymerase II large subunit DP2 central a+b domain (From Topology)	T: DNA polymerase II large subunit DP2 central a+b domain	F: PolC_DP2_4th	ECOD (1.6)
A	PolC_DP2_1st	e5ijlA1	A: a+b two layers	X: DNA polymerase D large subunit DP2 N-terminal domain (From Topology)	H: DNA polymerase D large subunit DP2 N-terminal domain (From Topology)	T: DNA polymerase D large subunit DP2 N-terminal domain	F: PolC_DP2_1st	ECOD (1.6)
A	PolC_DP2_5th	e5ijlA2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PolC_DP2_5th	ECOD (1.6)
A	IBR_1	e5ijlA3	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: IBR_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03833	DNA polymerase II large subunit DP2 (PolC_DP2)	DNA polymerase II large subunit DP2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA polymerase II large subunit	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding DNA exonuclease activity 3'-5' exonuclease activity catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups DNA binding binding organic cyclic compound binding nucleic acid binding DNA exonuclease activity 3'-5' exonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters single-stranded DNA exodeoxyribonuclease activity nuclease activity hydrolase activity, acting on ester bonds 3'-5'-DNA exonuclease activity exonuclease activity single-stranded DNA 3'-5' DNA exonuclease activity	catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process organic substance catabolic process intein-mediated protein splicing organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis organic substance biosynthetic process protein processing cellular process protein metabolic process protein splicing DNA-templated DNA replication DNA replication	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006141	Intein N-terminal splicing region	PTM
A	IPR016033	DNA polymerase II large subunit DP2, N-terminal	Domain
A	IPR036844	Hint domain superfamily	Homologous Superfamily
A	IPR003587	Hint domain N-terminal	Domain
A	IPR004475	DNA polymerase II large subunit DP2	Family
A	IPR030934	Intein C-terminal splicing region	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.