5IJ7
Structure of Hs/AcPRC2 in complex with a pyridone inhibitor
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
E [auth S] | SCOP2B Superfamily | VEFS box-like | 8090819 | 3002459 | SCOP2B (2022-06-29) |
F [auth T] | SCOP2 Family | VEFS box-like | 8045497 | 4004497 | SCOP2 (2022-06-29) |
F [auth T] | SCOP2 Superfamily | VEFS box-like | 8090819 | 3002459 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00856 | e5ij7A2 | A: beta barrels | X: beta-clip | H: SET domain-like (From Topology) | T: SET domain-like | F: PF00856 | ECOD (1.6) |
A | F_UNCLASSIFIED | e5ij7A8 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: F_UNCLASSIFIED | ECOD (1.6) |
A | PF18118 | e5ij7A6 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: PF18118 | ECOD (1.6) |
A | F_UNCLASSIFIED | e5ij7A7 | A: few secondary structure elements | X: Zn3Cys9 preSET domain-related (From Topology) | H: Zn3Cys9 preSET domain-related (From Topology) | T: Zn3Cys9 preSET domain-related | F: F_UNCLASSIFIED | ECOD (1.6) |
A | PF18264 | e5ij7A3 | A: few secondary structure elements | X: Zn3Cys9 preSET domain-related (From Topology) | H: Zn3Cys9 preSET domain-related (From Topology) | T: Zn3Cys9 preSET domain-related | F: PF18264 | ECOD (1.6) |
A | PF21358 | e5ij7A4 | A: few secondary structure elements | X: Ezh2 MCSS domain (From Topology) | H: Ezh2 MCSS domain (From Topology) | T: Ezh2 MCSS domain | F: PF21358 | ECOD (1.6) |
A | PF11616 | e5ij7A1 | A: extended segments | X: Ezh2 N-terminal domain (From Topology) | H: Ezh2 N-terminal domain (From Topology) | T: Ezh2 N-terminal domain | F: PF11616 | ECOD (1.6) |
B | PF00856 | e5ij7B1 | A: beta barrels | X: beta-clip | H: SET domain-like (From Topology) | T: SET domain-like | F: PF00856 | ECOD (1.6) |
B | F_UNCLASSIFIED | e5ij7B7 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF18118 | e5ij7B6 | A: alpha arrays | X: HTH | H: HTH | T: tri-helical | F: PF18118 | ECOD (1.6) |
B | F_UNCLASSIFIED | e5ij7B5 | A: few secondary structure elements | X: Zn3Cys9 preSET domain-related (From Topology) | H: Zn3Cys9 preSET domain-related (From Topology) | T: Zn3Cys9 preSET domain-related | F: F_UNCLASSIFIED | ECOD (1.6) |
B | PF18264 | e5ij7B4 | A: few secondary structure elements | X: Zn3Cys9 preSET domain-related (From Topology) | H: Zn3Cys9 preSET domain-related (From Topology) | T: Zn3Cys9 preSET domain-related | F: PF18264 | ECOD (1.6) |
B | PF21358 | e5ij7B3 | A: few secondary structure elements | X: Ezh2 MCSS domain (From Topology) | H: Ezh2 MCSS domain (From Topology) | T: Ezh2 MCSS domain | F: PF21358 | ECOD (1.6) |
B | PF11616 | e5ij7B2 | A: extended segments | X: Ezh2 N-terminal domain (From Topology) | H: Ezh2 N-terminal domain (From Topology) | T: Ezh2 N-terminal domain | F: PF11616 | ECOD (1.6) |
C [auth E] | PF00400 | e5ij7E1 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: PF00400 | ECOD (1.6) |
D [auth F] | PF00400 | e5ij7F1 | A: beta duplicates or obligate multimers | X: beta-propeller-like | H: beta-propeller | T: 7-bladed | F: PF00400 | ECOD (1.6) |
E [auth S] | PF09733 | e5ij7S1 | A: alpha arrays | X: lambda integrase-N-like | H: VEFS domain (From Topology) | T: VEFS domain | F: PF09733 | ECOD (1.6) |
F [auth T] | PF09733 | e5ij7T1 | A: alpha arrays | X: lambda integrase-N-like | H: VEFS domain (From Topology) | T: VEFS domain | F: PF09733 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C [auth E] | 2.130.10.10 | Mainly Beta | 7 Propeller | Methylamine Dehydrogenase | Chain H | CATH (4.3.0) |
D [auth F] | 2.130.10.10 | Mainly Beta | 7 Propeller | Methylamine Dehydrogenase | Chain H | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF18264 | CXC domain (preSET_CXC) | CXC domain | This domain is found to the N-terminus of the SET domain in the EZH2 protein [1]. It is a zinc binding domain. | Domain | |
PF00856 | SET domain (SET) | SET domain | - | Family | |
PF11616 | WD repeat binding protein EZH2 (EZH2_WD-Binding) | WD repeat binding protein EZH2 | - | Family | |
C [auth E], D [auth F] | PF00400 | WD domain, G-beta repeat (WD40) | WD domain, G-beta repeat | - | Repeat |
E [auth S], F [auth T] | PF09733 | VEFS-Box of polycomb protein (VEFS-Box) | VEFS-Box of polycomb protein | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR048358 | EZH1/2, MCSS domain | Domain | |
IPR041343 | Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain | Domain | |
IPR046341 | SET domain superfamily | Homologous Superfamily | |
IPR033467 | Tesmin/TSO1-like CXC domain | Domain | |
IPR044439 | EZH2, SET domain | Domain | |
IPR041355 | Pre-SET CXC domain | Domain | |
IPR001214 | SET domain | Domain | |
IPR001005 | SANT/Myb domain | Domain | |
IPR045318 | Histone-lysine N-methyltransferase EZH1/2-like | Family | |
IPR021654 | Histone-lysine N-methyltransferase EZH1/EZH2 | Family | |
IPR026489 | CXC domain | Domain | |
C [auth E], D [auth F] | IPR019775 | WD40 repeat, conserved site | Conserved Site |
C [auth E], D [auth F] | IPR036322 | WD40-repeat-containing domain superfamily | Homologous Superfamily |
C [auth E], D [auth F] | IPR001680 | WD40 repeat | Repeat |
C [auth E], D [auth F] | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily | Homologous Superfamily |
E [auth S], F [auth T] | IPR019135 | Polycomb protein, VEFS-Box | Domain |