5IGO

WD40 domain of Arabidopsis thaliana E3 Ubiquitin Ligase COP1 in complex with peptide from Trib1

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANAPC4_WD40_8	e5igoA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_8	ECOD (1.6)
C [auth B]	ANAPC4_WD40_8	e5igoB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_8	ECOD (1.6)
E [auth C]	ANAPC4_WD40_8	e5igoC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_8	ECOD (1.6)
G [auth D]	ANAPC4_WD40_8	e5igoD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C [auth B]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
E [auth C]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G [auth D]	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], G [auth D]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D]	E3 ubiquitin-protein ligase COP1	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	response to light stimulus response to stimulus shade avoidance response to radiation response to abiotic stimulus response to red or far red light regulation of stomatal movement regulation of biological process regulation of cellular process stomatal movement biological regulation cellular process cellular response to stimulus cellular response to red or far red light response to light stimulus response to stimulus shade avoidance response to radiation response to abiotic stimulus response to red or far red light regulation of stomatal movement regulation of biological process regulation of cellular process stomatal movement biological regulation cellular process cellular response to stimulus cellular response to red or far red light signaling detection of abiotic stimulus cell communication cellular response to environmental stimulus cellular response to light stimulus signal transduction phototransduction detection of light stimulus detection of external stimulus red or far-red light signaling pathway response to external stimulus cellular response to radiation detection of stimulus red, far-red light phototransduction cellular response to abiotic stimulus rhythmic process entrainment of circadian clock circadian rhythm regulation of circadian rhythm developmental process multicellular organismal process multicellular organism development photomorphogenesis anatomical structure development post-embryonic development response to UV response to UV-B organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of biosynthetic process flavonoid metabolic process positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process regulation of flavonoid biosynthetic process biosynthetic process flavonoid biosynthetic process positive regulation of biosynthetic process positive regulation of flavonoid biosynthetic process organic substance biosynthetic process regulation of metabolic process pigment metabolic process anthocyanin-containing compound metabolic process photoperiodism, flowering reproductive system development reproductive process vegetative to reproductive phase transition of meristem developmental process involved in reproduction photoperiodism reproductive structure development system development response to light intensity response to absence of light skotomorphogenesis DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process cellular response to stress DNA damage response response to stress DNA repair	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex cullin-RING ubiquitin ligase complex Cul4-RING E3 ubiquitin ligase complex
B [auth U], D [auth V], F [auth W], H [auth X]	Tribbles homolog 1	enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding enzyme regulator activity protein kinase inhibitor activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity kinase regulator activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding ubiquitin-protein transferase regulator activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding	regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of transferase activity negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process regulation of cellular process regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of transferase activity negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process regulation of biological process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process organic substance metabolic process negative regulation of cellular process protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process biological regulation negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process regulation of phosphorylation cellular process negative regulation of phosphorylation cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of locomotion regulation of cell motility regulation of smooth muscle cell migration smooth muscle cell migration muscle cell migration negative regulation of smooth muscle cell migration regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility locomotion negative regulation of cell migration multicellular organismal process myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of granulocyte differentiation cellular developmental process regulation of developmental process positive regulation of biological process regulation of eosinophil differentiation cell development regulation of cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell differentiation positive regulation of hemopoiesis cell differentiation anatomical structure development regulation of immune system process regulation of multicellular organismal process positive regulation of immune system process positive regulation of cellular process developmental process regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation eosinophil differentiation myeloid cell differentiation granulocyte differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of eosinophil differentiation positive regulation of granulocyte differentiation positive regulation of leukocyte differentiation leukocyte differentiation cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade signal transduction regulation of MAP kinase activity regulation of protein serine/threonine kinase activity regulation of lipopolysaccharide-mediated signaling pathway negative regulation of lipopolysaccharide-mediated signaling pathway regulation of response to biotic stimulus response to organic substance biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus regulation of response to external stimulus response to lipid negative regulation of signaling cellular response to lipopolysaccharide regulation of signal transduction response to biotic stimulus negative regulation of cell communication lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium cellular response to organic substance response to external biotic stimulus regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus response to other organism response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin negative regulation of signal transduction response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus negative regulation of response to external stimulus response to chemical cellular response to lipid regulation of cell communication response to molecule of bacterial origin regulation of neutrophil differentiation negative regulation of neutrophil differentiation negative regulation of cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of developmental process negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of granulocyte differentiation negative regulation of immune system process neutrophil differentiation negative regulation of multicellular organismal process mononuclear cell differentiation regulation of macrophage differentiation macrophage differentiation positive regulation of macrophage differentiation negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process organonitrogen compound catabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of protein catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D]	IPR019775	WD40 repeat, conserved site	Conserved Site
A, C [auth B], E [auth C], G [auth D]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
A, C [auth B], E [auth C], G [auth D]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D]	IPR042755	E3 ubiquitin-protein ligase COP1	Family
A, C [auth B], E [auth C], G [auth D]	IPR001680	WD40 repeat	Repeat
A, C [auth B], E [auth C], G [auth D]	IPR001841	Zinc finger, RING-type	Domain
B [auth U], D [auth V], F [auth W], H [auth X]	IPR024105	Tribbles homologue 1, pseudokinase domain	Domain
B [auth U], D [auth V], F [auth W], H [auth X]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B [auth U], D [auth V], F [auth W], H [auth X]	IPR024104	Pseudokinase tribbles family/serine-threonine-protein kinase 40	Family
B [auth U], D [auth V], F [auth W], H [auth X]	IPR000719	Protein kinase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth U], D [auth V], F [auth W], H [auth X]	Pharos: Q96RU8	coronary artery disease non-alcoholic fatty liver disease lung cancer MALT lymphoma myocardial infarction non-small cell lung carcinoma abdominal aortic aneurysm polycystic ovary syndrome ulcerative colitis adrenal cortex carcinoma Barrett esophagus Coronary Arteriosclerosis dermatomyositis heart disease interstitial lung disease coronary artery disease non-alcoholic fatty liver disease lung cancer MALT lymphoma myocardial infarction non-small cell lung carcinoma abdominal aortic aneurysm polycystic ovary syndrome ulcerative colitis adrenal cortex carcinoma Barrett esophagus Coronary Arteriosclerosis dermatomyositis heart disease interstitial lung disease lung large cell carcinoma metabolic disease nephrosclerosis osteosarcoma adenoma rheumatoid arthritis astrocytic tumor breast cancer esophageal adenocarcinoma inflammatory bowel disease large cell medulloblastoma lymphoplasmacytic lymphoma metabolic syndrome X ovarian cancer sinusitis adrenal cortex adenoma B-cell chronic lymphocytic leukemia congestive heart failure Crohn disease glioblastoma interstitial cystitis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.