Annotations: 5I04

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5i04A2	A: beta duplicates or obligate multimers	X: Endoglin orphan region (OR) domain (From Topology)	H: Endoglin orphan region (OR) domain (From Topology)	T: Endoglin orphan region (OR) domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF01547	e5i04A3	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: PF01547	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01547	Bacterial extracellular solute-binding protein (SBP_bac_1)	Bacterial extracellular solute-binding protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Maltose-binding periplasmic protein,Endoglin	transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding molecular transducer activity coreceptor activity signaling receptor activity transforming growth factor beta receptor binding protein binding signaling receptor binding transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding molecular transducer activity coreceptor activity signaling receptor activity transforming growth factor beta receptor binding protein binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding galactose binding monosaccharide binding small molecule binding protein-containing complex binding activin binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity transforming growth factor beta receptor activity identical protein binding transforming growth factor beta binding growth factor binding cytokine binding type II transforming growth factor beta receptor binding protein homodimerization activity protein dimerization activity glycosaminoglycan binding carbohydrate derivative binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity signaling receptor activator activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility locomotion localization transport organic substance transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport response to organic substance response to disaccharide response to oxygen-containing compound detection of maltose stimulus detection of stimulus response to carbohydrate detection of chemical stimulus detection of disaccharide stimulus response to maltose detection of carbohydrate stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling response to xenobiotic stimulus cell adhesion regulation of cell adhesion phosphorylation cellular metabolic process regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorylation regulation of phosphorus metabolic process metabolic process phosphorus metabolic process regulation of metabolic process multicellular organismal process smooth muscle cell differentiation cellular developmental process regulation of developmental process positive regulation of smooth muscle cell differentiation regulation of smooth muscle cell differentiation regulation of cell differentiation muscle cell differentiation muscle structure development positive regulation of developmental process multicellular organism development vascular associated smooth muscle cell differentiation positive regulation of cell differentiation cell differentiation anatomical structure development system development developmental process positive regulation of vascular associated smooth muscle cell differentiation regulation of vascular associated smooth muscle cell differentiation positive regulation of muscle cell differentiation vasculature development circulatory system development regulation of muscle cell differentiation cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cellular biosynthetic process cardiac atrium morphogenesis heart morphogenesis striated muscle tissue development cardiac chamber development animal organ morphogenesis muscle tissue development muscle organ development heart development cardiac chamber morphogenesis atrial cardiac muscle tissue morphogenesis cardiac muscle tissue development animal organ development cardiac atrium development tissue development atrial cardiac muscle tissue development muscle tissue morphogenesis anatomical structure morphogenesis tissue morphogenesis cardiac muscle tissue morphogenesis muscle organ morphogenesis skeletal system development bone development negative regulation of monooxygenase activity regulation of catalytic activity negative regulation of oxidoreductase activity negative regulation of molecular function negative regulation of catalytic activity regulation of oxidoreductase activity negative regulation of nitric-oxide synthase activity regulation of molecular function regulation of monooxygenase activity regulation of nitric-oxide synthase activity cardiac ventricle morphogenesis cardiac ventricle development blood vessel morphogenesis tube development artery development tube morphogenesis artery morphogenesis blood vessel development response to decreased oxygen levels detection of hypoxia response to hypoxia response to oxygen levels response to abiotic stimulus detection of oxygen cardiac septum development cardiac septum morphogenesis outflow tract septum morphogenesis outflow tract morphogenesis central nervous system vasculogenesis vasculogenesis negative regulation of transforming growth factor beta receptor signaling pathway cellular response to growth factor stimulus negative regulation of signaling cellular response to transforming growth factor beta stimulus negative regulation of biological process negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway branching morphogenesis of an epithelial tube angiogenesis epithelial tube morphogenesis epithelium development morphogenesis of an epithelium branching involved in blood vessel morphogenesis morphogenesis of a branching structure anatomical structure formation involved in morphogenesis morphogenesis of a branching epithelium RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility negative regulation of cell migration negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of systemic arterial blood pressure system process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure positive regulation of blood pressure regulation of biological quality blood circulation endocardial cushion morphogenesis endocardial cushion development cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation mesenchyme morphogenesis endocardial cushion formation collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process pattern specification process embryo development embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis embryonic morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue development ventricular trabecula myocardium morphogenesis heart trabecula morphogenesis trabecula morphogenesis venous blood vessel development venous blood vessel morphogenesis cellular response to BMP stimulus response to BMP BMP signaling pathway secretion export from cell extracellular matrix organization cellular component organization secretion by cell extracellular matrix constituent secretion cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization cell development muscle cell development vascular associated smooth muscle cell development regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular component disassembly extracellular matrix disassembly positive regulation of BMP signaling pathway regulation of BMP signaling pathway regulation of epithelial to mesenchymal transition positive regulation of cardiac epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition regulation of multicellular organismal process regulation of cardiac epithelial to mesenchymal transition positive regulation of multicellular organismal process regulation of epithelial to mesenchymal transition involved in endocardial cushion formation response to mechanical stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis wound healing response to wounding cell population proliferation regulation of cell population proliferation cell migration involved in heart development cell migration involved in endocardial cushion formation smooth muscle tissue development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein phosphorylation protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process regulation of protein metabolic process macromolecule modification negative regulation of gene expression atrioventricular canal morphogenesis atrioventricular canal development negative regulation of cell population proliferation endothelial cell proliferation negative regulation of endothelial cell proliferation regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation aorta morphogenesis aorta development dorsal aorta morphogenesis dorsal aorta development	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space outer membrane-bounded periplasmic space cell envelope cell surface external side of plasma membrane side of membrane receptor complex extracellular region extracellular space anchoring junction cell junction focal adhesion cell-substrate junction endothelial microparticle blood microparticle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006061	Solute-binding family 1, conserved site	Conserved Site
A	IPR006060	Maltose/Cyclodextrin ABC transporter, substrate-binding protein	Family
A	IPR006059	Bacterial-type extracellular solute-binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P17813	hereditary hemorrhagic telangiectasia telangiectasia, hereditary hemorrhagic, type 1 juvenile polyposis syndrome malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm aneurysm, intracranial berry type 1 primary pulmonary hypertension cancer cystic fibrosis transitional cell carcinoma gastric carcinoma glioblastoma idiopathic pulmonary arterial hypertension Juvenile Polyposis Coli hereditary hemorrhagic telangiectasia telangiectasia, hereditary hemorrhagic, type 1 juvenile polyposis syndrome malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm aneurysm, intracranial berry type 1 primary pulmonary hypertension cancer cystic fibrosis transitional cell carcinoma gastric carcinoma glioblastoma idiopathic pulmonary arterial hypertension Juvenile Polyposis Coli lung adenocarcinoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia arteriovenous hemangioma/malformation pulmonary arterial hypertension cerebrovascular disorder telangiectasis tuberculosis interstitial cystitis lung carcinoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma primary angle-closure glaucoma astrocytic tumor subependymal giant cell astrocytoma chronic obstructive pulmonary disease thoracic aortic aneurysm ulcerative colitis generalized juvenile polyposis/juvenile polyposis coli hypertensive disorder invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.