5HZP

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth B]	PF00084	e5hzpB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: PF00084	ECOD (1.6)
D	PF00084	e5hzpD2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: PF00084	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth B]	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
D	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth B], D	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A]	M protein, serotype 49	-	localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport	extracellular region cellular anatomical entity
C [auth B], D	C4b-binding protein alpha chain	RNA binding binding organic cyclic compound binding nucleic acid binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated immunity response to stimulus immune response immune system process leukocyte mediated immunity adaptive immune response immune effector process humoral immune response positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated immunity response to stimulus immune response immune system process leukocyte mediated immunity adaptive immune response immune effector process humoral immune response positive regulation of biological process positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response regulation of immune system process positive regulation of immune system process complement activation, classical pathway regulation of biological process biological regulation immunoglobulin mediated immune response regulation of response to stimulus B cell mediated immunity regulation of immune response activation of immune response response to symbiont biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to symbiotic bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus defense response defense response to symbiont defense response to other organism response to stress innate immune response regulation of humoral immune response regulation of immune effector process regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of biological process negative regulation of lymphocyte mediated immunity negative regulation of complement activation, classical pathway negative regulation of B cell mediated immunity regulation of adaptive immune response negative regulation of immune response negative regulation of immune effector process negative regulation of humoral immune response negative regulation of adaptive immune response regulation of B cell mediated immunity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity negative regulation of immunoglobulin mediated immune response regulation of complement activation, classical pathway regulation of complement activation negative regulation of complement activation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response negative regulation of response to stimulus negative regulation of humoral immune response mediated by circulating immunoglobulin regulation of lymphocyte mediated immunity negative regulation of immune system process negative regulation of leukocyte mediated immunity catabolic process positive regulation of protein metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process import into cell regulation of cellular process transport establishment of localization regulation of opsonization vesicle-mediated transport phagocytosis, recognition opsonization localization cellular process phagocytosis cell recognition endocytosis	extracellular region extracellular space cellular anatomical entity blood microparticle cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A]	IPR003345	M protein repeat	Repeat
A [auth C], B [auth A]	IPR019950	M protein-type anchor domain	Domain
A [auth C], B [auth A]	IPR005877	YSIRK Gram-positive signal peptide	Domain
A [auth C], B [auth A]	IPR019931	LPXTG cell wall anchor domain	Domain
C [auth B], D	IPR040514	C4b-binding protein alpha, oligomerization domain	Domain
C [auth B], D	IPR000436	Sushi/SCR/CCP domain	Domain
C [auth B], D	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth B], D	Pharos: P04003	attention deficit hyperactivity disorder, inattentive type lung adenocarcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm vascular disease breast cancer lung cancer ovarian cancer schizophrenia Crohn disease lung carcinoma pancreatic ductal adenocarcinoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.