5HZN

Structure of NVP-AEW541 in complex with IGF-1R kinase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5hzna_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5hznb_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5hznc_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5hznd_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d5hzne_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d5hznf_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d5hzng_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d5hznh_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Insulin-like growth factor 1 receptor	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Protein kinase-like (PK-like)	8034606	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e5hznA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e5hznB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
C	Pkinase_Tyr	e5hznC1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D	Pkinase_Tyr	e5hznD1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
E	Pkinase_Tyr	e5hznE1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
F	Pkinase_Tyr	e5hznF1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
G	Pkinase_Tyr	e5hznG1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
H	Pkinase_Tyr	e5hznH1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
C	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
C	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
E	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
E	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
F	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
F	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
G	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
G	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
H	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
H	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Insulin-like growth factor 1 receptor	insulin-like growth factor binding protein binding binding growth factor binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity insulin-like growth factor binding protein binding binding growth factor binding insulin receptor substrate binding amide binding peptide hormone binding hormone binding insulin binding molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein-hormone receptor activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity insulin receptor activity catalytic activity signaling receptor binding insulin receptor binding phosphatidylinositol 3-kinase binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-containing complex binding G-protein alpha-subunit binding insulin-like growth factor receptor activity identical protein binding insulin-like growth factor I binding protein transporter activity transporter activity	cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development positive regulation of cell projection organization response to wounding system development positive regulation of response to wounding developmental process regulation of biological process regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of response to stimulus regulation of neuron projection regeneration regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process cellular developmental process regulation of response to external stimulus positive regulation of biological process cell development response to axon injury regulation of response to wounding positive regulation of response to stimulus cellular component organization neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development response to stress regulation of response to stress cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization biological regulation axon development neuron development cellular process positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization cellular component disassembly protein-containing complex organization protein-containing complex disassembly regulation of protein-containing complex disassembly positive regulation of protein-containing complex disassembly organonitrogen compound metabolic process protein phosphorylation protein autophosphorylation phosphorylation cellular metabolic process primary metabolic process peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation organic substance metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process peptidyl-tyrosine phosphorylation protein modification process phosphorus metabolic process cellular response to nitrogen compound response to organic substance response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical cellular response to organic substance cellular response to insulin-like growth factor stimulus cellular response to hormone stimulus regulation of cytokinesis positive regulation of cell division regulation of cell cycle process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cell division cell cycle regulation of cell cycle cell cycle process regulation of signaling signaling regulation of JNK cascade regulation of signal transduction regulation of MAPK cascade intracellular signal transduction cell communication regulation of intracellular signal transduction JNK cascade intracellular signaling cassette MAPK cascade regulation of cell communication signal transduction ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process response to ketone response to lipid response to progesterone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to organic cyclic compound cellular response to progesterone stimulus cellular response to lipid head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development establishment of cell polarity establishment or maintenance of cell polarity negative regulation of hepatocyte apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process hepatocyte apoptotic process negative regulation of cellular process apoptotic process programmed cell death cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone cellular senescence axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis negative regulation of cholangiocyte apoptotic process cholangiocyte apoptotic process regulation of cholangiocyte apoptotic process cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation response to nutrient levels response to zinc ion starvation cellular response to starvation cellular response to nutrient levels response to starvation cellular response to zinc ion starvation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation response to acid chemical response to L-glutamate response to amino acid response to nutrient response to vitamin E response to vitamin positive regulation of nucleobase-containing compound metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process positive regulation of metabolic process positive regulation of DNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA metabolic process forebrain development pallium development telencephalon development hippocampus development limbic system development immune response immune system process phosphatidylinositol 3-kinase/protein kinase B signal transduction cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to growth factor homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis chemical homeostasis response to glucose glucose homeostasis amyloid-beta clearance cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to aldehyde cellular response to aldosterone response to aldosterone response to alcohol cellular response to alcohol heart development cardiac chamber development cardiac atrium development circulatory system development positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling regulation of steroid biosynthetic process positive regulation of steroid hormone biosynthetic process regulation of hormone biosynthetic process cellular biosynthetic process regulation of hormone metabolic process regulation of lipid metabolic process steroid metabolic process lipid biosynthetic process positive regulation of cellular metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of lipid metabolic process regulation of biological quality hormone biosynthetic process steroid biosynthetic process regulation of biosynthetic process regulation of steroid hormone biosynthetic process positive regulation of hormone metabolic process regulation of hormone levels regulation of steroid metabolic process regulation of cellular metabolic process hormone metabolic process regulation of cellular biosynthetic process positive regulation of steroid biosynthetic process biosynthetic process positive regulation of lipid biosynthetic process organic cyclic compound biosynthetic process positive regulation of steroid metabolic process positive regulation of hormone biosynthetic process regulation of lipid biosynthetic process positive regulation of cellular biosynthetic process lipid metabolic process response to ethanol adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process regulation of multicellular organismal process negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of response to stimulus negative regulation of signal transduction negative regulation of MAPK cascade positive regulation of MAPK cascade dendritic spine maintenance dendritic spine organization postsynapse organization cellular component maintenance cell junction organization neuron projection organization synapse organization response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus insulin receptor signaling pathway response to insulin cellular response to insulin stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion localization transport establishment of localization transcytosis vesicle-mediated transport cellular response to testosterone stimulus response to testosterone response to estradiol cellular response to estradiol stimulus muscle cell apoptotic process regulation of muscle cell apoptotic process negative regulation of muscle cell apoptotic process response to alkaloid response to nicotine cellular response to amyloid-beta response to amyloid-beta response to angiotensin cellular response to angiotensin	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex receptor complex plasma membrane protein complex alphav-beta3 integrin-IGF-1-IGF1R complex cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex receptor complex plasma membrane protein complex alphav-beta3 integrin-IGF-1-IGF1R complex membrane protein complex somatodendritic compartment cell body neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle insulin receptor complex plasma membrane signaling receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000719	Protein kinase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR006212	Furin-like repeat	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR000494	Receptor L-domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR003961	Fibronectin type III	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR006211	Furin-like cysteine-rich domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR016246	Tyrosine-protein kinase, insulin-like receptor	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: P08069	growth delay due to insulin-like growth factor I resistance Alzheimer disease adrenal cortex carcinoma peripheral nervous system disease respiratory failure Lewy body dementia skin cancer congenital diaphragmatic hernia endometrial carcinoma peripheral neuropathy juvenile idiopathic arthritis atrial fibrillation breast cancer skin neoplasm Parkinson disease growth delay due to insulin-like growth factor I resistance Alzheimer disease adrenal cortex carcinoma peripheral nervous system disease respiratory failure Lewy body dementia skin cancer congenital diaphragmatic hernia endometrial carcinoma peripheral neuropathy juvenile idiopathic arthritis atrial fibrillation breast cancer skin neoplasm Parkinson disease breast carcinoma lung disease malignant glioma Congenital hernia of foramen of Morgagni endometrial cancer non-small cell lung carcinoma endometriosis osteosarcoma pancreatic intraductal papillary-mucinous carcinoma adrenal carcinoma intellectual disability pilocytic astrocytoma primitive neuroectodermal tumor astrocytic tumor atypical teratoid rhabdoid tumor breast disease squamous cell lung carcinoma diabetes mellitus medulloblastoma oligodendroglioma genetic endocrine growth disease ovarian cancer pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia inborn carbohydrate metabolic disorder interstitial cystitis progressive supranuclear palsy large cell medulloblastoma cancer malignant ependymoma endocrine exophthalmos osteogenesis imperfecta fetal growth restriction glioblastoma pancreatic ductal adenocarcinoma hepatocellular carcinoma adenoma Pick disease intervertebral disc degenerative disorder attention deficit hyperactivity disorder, inattentive type Laron syndrome Silver-Russell syndrome spina bifida

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.