Annotations: 5HTL

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5htlA1	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF05157	e5htlA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)
B	F_UNCLASSIFIED	e5htlB2	A: alpha arrays	X: MshE c-di-GMP-binding domain (From Topology)	H: MshE c-di-GMP-binding domain (From Topology)	T: MshE c-di-GMP-binding domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF05157	e5htlB1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: GSPII protein E N-terminal domain-like (From Topology)	T: GSPII protein E N-terminal domain-like	F: PF05157	ECOD (1.6)

Chains	Accession	Name	Description	Comments	Source
A, B	PF05157	MshEN domain (MshEN)	MshEN domain	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di- ...	This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [4,6,7], which modulates the activity of the respective protein. The structure of this domain is now known [1,2,4].	Domain

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MSHA biogenesis protein MshE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	-	cell periphery plasma membrane membrane cellular anatomical entity

Chains	Accession	Name	Type
A, B	IPR001482	Type II/IV secretion system domain	Domain
A, B	IPR003593	AAA+ ATPase domain	Domain
A, B	IPR037257	Type II secretion system protein GspE, N-terminal superfamily	Homologous Superfamily
A, B	IPR007831	Type II secretion system protein GspE, N-terminal	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily