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Crystal structure of the dehydratase domain of MlnB from Bacillus amyloliquefaciens External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PS-DH_N e5hstA2 A: a+b two layers X: Thioesterase/thiol ester dehydrase-isomerase-like H: Thioesterase/thiol ester dehydrase-isomerase (From Topology) T: Thioesterase/thiol ester dehydrase-isomerase F: PS-DH_N ECOD (1.6) A PS-DH_C e5hstA1 A: a+b two layers X: Thioesterase/thiol ester dehydrase-isomerase-like H: Thioesterase/thiol ester dehydrase-isomerase (From Topology) T: Thioesterase/thiol ester dehydrase-isomerase F: PS-DH_C ECOD (1.6) B PS-DH_N e5hstB2 A: a+b two layers X: Thioesterase/thiol ester dehydrase-isomerase-like H: Thioesterase/thiol ester dehydrase-isomerase (From Topology) T: Thioesterase/thiol ester dehydrase-isomerase F: PS-DH_N ECOD (1.6) B PS-DH_C e5hstB1 A: a+b two layers X: Thioesterase/thiol ester dehydrase-isomerase-like H: Thioesterase/thiol ester dehydrase-isomerase (From Topology) T: Thioesterase/thiol ester dehydrase-isomerase F: PS-DH_C ECOD (1.6)
Chains Accession Name Description Comments Source PF21089 Polyketide synthase dehydratase domain (PKS_DH_N) Polyketide synthase dehydratase domain This domain is part of a dehydratase domain found in diverse PKS enzymes. This domain adopts a HotDog fold. Domain PF14765 Polyketide synthase dehydratase N-terminal domain (PS-DH) Polyketide synthase dehydratase N-terminal domain This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and ... This entry represents the N-terminal HotDog domain of the dehydratase (DH) module of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products [2]. Less Domain
Chains Polymer Molecular Function Biological Process Cellular Component Polyketide synthase type I -
Chains Accession Name Type IPR014031 Beta-ketoacyl synthase, C-terminal Domain IPR006162 Phosphopantetheine attachment site PTM IPR049490 C883_1060-like, ketoreductase domain, N-terminal Domain IPR032821 Polyketide synthase, C-terminal extension Domain IPR009081 Phosphopantetheine binding ACP domain Domain IPR020807 Polyketide synthase, dehydratase domain Domain IPR014030 Beta-ketoacyl synthase, N-terminal Domain IPR049552 Polyketide synthase, dehydratase domain, N-terminal Domain IPR049551 Polyketide synthase, dehydratase domain, C-terminal Domain IPR013968 Polyketide synthase, ketoreductase domain Domain IPR016039 Thiolase-like Homologous Superfamily IPR036291 NAD(P)-binding domain superfamily Homologous Superfamily IPR020806 Polyketide synthase, phosphopantetheine-binding domain Domain IPR018201 Beta-ketoacyl synthase, active site Active Site IPR020841 Polyketide synthase, beta-ketoacyl synthase domain Domain IPR036736 ACP-like superfamily Homologous Superfamily IPR020615 Thiolase, acyl-enzyme intermediate active site Active Site IPR042104 Polyketide synthase, dehydratase domain superfamily Homologous Superfamily