5HJQ

Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00566	e5hjqA2	A: alpha arrays	X: Ypt/Rab-GAP domain of gyp1p-like	H: Ypt/Rab-GAP domain of gyp1p (From Topology)	T: Ypt/Rab-GAP domain of gyp1p	F: PF00566	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00566	Rab-GTPase-TBC domain (RabGAP-TBC)	Rab-GTPase-TBC domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	LD10117p	binding lipid binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	localization transport cellular process establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse regulation of localization cellular localization regulation of biological process regulation of transport synaptic vesicle cycle biological regulation negative regulation of biological process regulation of synaptic vesicle recycling localization transport cellular process establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse regulation of localization cellular localization regulation of biological process regulation of transport synaptic vesicle cycle biological regulation negative regulation of biological process regulation of synaptic vesicle recycling negative regulation of transport synaptic vesicle recycling establishment of localization in cell negative regulation of synaptic vesicle recycling trans-synaptic signaling synaptic signaling signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission cell communication regulation of cellular process modulation of chemical synaptic transmission negative regulation of neurotransmitter transport regulation of secretion by cell secretion by cell negative regulation of secretion signal release negative regulation of cellular process negative regulation of secretion by cell regulation of signaling negative regulation of neurotransmitter secretion neurotransmitter secretion secretion regulation of neurotransmitter transport export from cell neurotransmitter transport regulation of secretion signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion regulation of cell communication synaptic vesicle endosomal processing intracellular transport endosomal transport regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity synaptic vesicle recycling via endosome neuromuscular synaptic transmission developmental process multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development cellular component organization generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation neuron development anatomical structure development cellular component organization or biogenesis system development	neuromuscular junction synapse cell junction cellular anatomical entity axon neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton neuron projection terminus endosome membrane neuromuscular junction synapse cell junction cellular anatomical entity axon neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton neuron projection terminus endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane transport vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane secretory vesicle exocytic vesicle postsynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006571	TLDc domain	Domain
A	IPR035969	Rab-GAP-TBC domain superfamily	Homologous Superfamily
A	IPR000195	Rab-GAP-TBC domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.