Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor
External Resource: Annotation
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
A | SCOP2 Family | Zn metallo-beta-lactamase | 8061852 | 4002289 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Metallo-hydrolase/oxidoreductase | 8061853 | 3001057 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | Metallo-hydrolase/oxidoreductase | 8061853 | 3001057 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Metallo-hydrolase/oxidoreductase | 8061853 | 3001057 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Metallo-hydrolase/oxidoreductase | 8061853 | 3001057 | SCOP2B (2022-06-29) |
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
A | PF00753 | e5hh4A1 | A: a+b four layers | X: Metallo-hydrolase/oxidoreductase (From Topology) | H: Metallo-hydrolase/oxidoreductase (From Topology) | T: Metallo-hydrolase/oxidoreductase | F: PF00753 | ECOD (1.6) |
B | PF00753 | e5hh4B1 | A: a+b four layers | X: Metallo-hydrolase/oxidoreductase (From Topology) | H: Metallo-hydrolase/oxidoreductase (From Topology) | T: Metallo-hydrolase/oxidoreductase | F: PF00753 | ECOD (1.6) |
C | PF00753 | e5hh4C1 | A: a+b four layers | X: Metallo-hydrolase/oxidoreductase (From Topology) | H: Metallo-hydrolase/oxidoreductase (From Topology) | T: Metallo-hydrolase/oxidoreductase | F: PF00753 | ECOD (1.6) |
D | PF00753 | e5hh4D1 | A: a+b four layers | X: Metallo-hydrolase/oxidoreductase (From Topology) | H: Metallo-hydrolase/oxidoreductase (From Topology) | T: Metallo-hydrolase/oxidoreductase | F: PF00753 | ECOD (1.6) |
Chains | Accession | Gene Family | Drug Class | Resistance Machanism | Provenance Source (Version) |
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| ARO:3000020 | IMP beta-lactamase | carbapenem, cephalosporin, cephamycin, penam, penem | antibiotic inactivation | CARD (3.2.9) |
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
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| Beta-lactamase IMP-1 | | | |