Annotations: 5HBV

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5hbva_	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	Bungarotoxin	(Bungarus multicinctus ) [TaxId: 8616 ],	SCOPe (2.08)
B	d5hbvb1	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d5hbvb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d5hbvc2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	(Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d5hbvc1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	(Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21947	e5hbvA1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF21947	ECOD (1.6)
B	PF02931	e5hbvB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
C	PF07654	e5hbvC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C	PF07686	e5hbvC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D	PF07654	e5hbvD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D	PF07686	e5hbvD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
C	Light Chain	IGKV22	Kappa	acetylcholine receptor subunit alpha 1	SAbDab (2024-04-26)
D	Heavy Chain	IGHV2	-	acetylcholine receptor subunit alpha 1	SAbDab (2024-04-26)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Alpha-bungarotoxin isoform V31	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity neurotransmitter receptor regulator activity acetylcholine receptor regulator activity molecular function inhibitor activity acetylcholine receptor inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity toxin activity	-	extracellular region cellular anatomical entity
B	Acetylcholine receptor subunit alpha 1	gated channel activity monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity molecular transducer activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential gated channel activity monoatomic ion channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity transmitter-gated monoatomic ion channel activity molecular transducer activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential transmitter-gated channel activity monoatomic cation transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity ligand-gated monoatomic cation channel activity monoatomic cation channel activity transmembrane signaling receptor activity	cellular component organization cell junction organization neuromuscular junction development cellular process synapse organization cellular component organization or biogenesis multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction cellular component organization cell junction organization neuromuscular junction development cellular process synapse organization cellular component organization or biogenesis multicellular organismal movement musculoskeletal movement multicellular organismal process system process nervous system process neuromuscular process skeletal muscle contraction muscle contraction muscle system process striated muscle contraction developmental process developmental growth skeletal muscle tissue development animal organ development growth tissue development muscle structure development skeletal muscle organ development skeletal muscle tissue growth anatomical structure development muscle tissue development muscle organ development localization transport monoatomic ion transport monoatomic cation transport establishment of localization trans-synaptic signaling regulation of biological process signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission action potential transmission of nerve impulse neuronal action potential regulation of biological quality regulation of membrane potential response to stimulus response to chemical response to nicotine synaptic transmission, cholinergic cellular homeostasis homeostatic process muscle cell cellular homeostasis neuron cellular homeostasis	membrane cellular anatomical entity cell surface cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization synapse synaptic membrane postsynapse organelle postsynaptic membrane cell junction plasma membrane region membrane cellular anatomical entity cell surface cell periphery plasma membrane postsynaptic specialization membrane postsynaptic specialization synapse synaptic membrane postsynapse organelle postsynaptic membrane cell junction plasma membrane region cell projection neuron projection plasma membrane bounded cell projection neuromuscular junction protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex
C	Fab35, Light Chain	-	-	-
D	Fab35, Heavy Chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018354	Snake toxin, conserved site	Conserved Site
A	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
A	IPR003571	Snake three-finger toxin	Family
B	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
B	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
B	IPR002394	Nicotinic acetylcholine receptor	Family
B	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
B	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
B	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
B	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
B	IPR006201	Neurotransmitter-gated ion-channel	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.