5H76

Crystal structure of the DARPin-Protein A fusion protein

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bacterial immunoglobulin/albumin-binding domains	8091639	3001373	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bacterial immunoglobulin/albumin-binding domains	8091639	3001373	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Bacterial immunoglobulin/albumin-binding domains	8091639	3001373	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02216	e5h76A2	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Bacterial immunoglobulin/albumin-binding domains (From Topology)	T: Bacterial immunoglobulin/albumin-binding domains	F: PF02216	ECOD (1.6)
A	PF13637	e5h76A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF13637	ECOD (1.6)
B	PF02216	e5h76B2	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Bacterial immunoglobulin/albumin-binding domains (From Topology)	T: Bacterial immunoglobulin/albumin-binding domains	F: PF02216	ECOD (1.6)
B	PF13637	e5h76B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF13637	ECOD (1.6)
C	PF02216	e5h76C2	A: alpha bundles	X: immunoglobulin/albumin-binding domain-like	H: Bacterial immunoglobulin/albumin-binding domains (From Topology)	T: Bacterial immunoglobulin/albumin-binding domains	F: PF02216	ECOD (1.6)
C	PF13637	e5h76C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF13637	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF02216	B domain (B)	B domain	This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	DARPin,Immunoglobulin G-binding protein A	protein-containing complex binding binding immunoglobulin binding IgG binding	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR009063	Immunoglobulin/albumin-binding domain superfamily	Homologous Superfamily
A, B, C	IPR005877	YSIRK Gram-positive signal peptide	Domain
A, B, C	IPR036779	LysM domain superfamily	Homologous Superfamily
A, B, C	IPR005038	Octapeptide repeat	Repeat
A, B, C	IPR003132	Protein A, Ig-binding domain	Domain
A, B, C	IPR018392	LysM domain	Domain
A, B, C	IPR019931	LPXTG cell wall anchor domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.