Annotations: 5H5M

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01044	e5h5mA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: PF01044	ECOD (1.6)
B	PF01044	e5h5mB2	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: PF01044	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)
B	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01044	Vinculin family (Vinculin)	Vinculin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha-catenin-like protein hmp-1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding cell adhesion molecule binding cadherin binding beta-catenin binding	developmental process multicellular organismal process embryonic morphogenesis embryo development gastrulation multicellular organism development anatomical structure morphogenesis ameboidal-type cell migration anatomical structure development cell migration cellular process cell motility cell migration involved in gastrulation cellular component organization developmental process multicellular organismal process embryonic morphogenesis embryo development gastrulation multicellular organism development anatomical structure morphogenesis ameboidal-type cell migration anatomical structure development cell migration cellular process cell motility cell migration involved in gastrulation cellular component organization organelle organization actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization biological regulation localization regulation of cellular localization cellular macromolecule localization macromolecule localization embryonic body morphogenesis body morphogenesis regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process regulation of organelle organization regulation of actin cytoskeleton organization cell adhesion cell-cell adhesion cell-cell adhesion mediated by cadherin	cell-cell junction adherens junction anchoring junction cell junction cellular anatomical entity cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane plasma membrane membrane protein complex extrinsic component of membrane cell-cell junction adherens junction anchoring junction cell junction cellular anatomical entity cell periphery protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane plasma membrane membrane protein complex extrinsic component of membrane intracellular anatomical structure cytoplasm apical junction complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036723	Alpha-catenin/vinculin-like superfamily	Homologous Superfamily
A, B	IPR006077	Vinculin/alpha-catenin	Family
A, B	IPR001033	Alpha-catenin	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.