Annotations: 5H3O

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00027	e5h3oA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
A	PF00520	e5h3oA2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
B	PF00027	e5h3oB1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
B	PF00520	e5h3oB2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
C	PF00027	e5h3oC1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
C	PF00520	e5h3oC2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
D	PF00027	e5h3oD1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: PF00027	ECOD (1.6)
D	PF00520	e5h3oD2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family
A, B, C, D	PF16526	C-terminal leucine zipper domain of cyclic nucleotide-gated channels (CLZ)	C-terminal leucine zipper domain of cyclic nucleotide-gated channels	-	Coiled-coil
A, B, C, D	PF00027	Cyclic nucleotide-binding domain (cNMP_binding)	Cyclic nucleotide-binding domain	This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Cyclic nucleotide-gated cation channel	monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly cyclic nucleotide-activated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity intracellularly cAMP-activated cation channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity cyclic nucleotide-activated monoatomic ion channel activity monoatomic cation transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity monoatomic ion channel activity intracellularly cyclic nucleotide-activated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity intracellularly cAMP-activated cation channel activity passive transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity ligand-gated monoatomic cation channel activity cyclic nucleotide-activated monoatomic ion channel activity transmembrane transporter activity intracellularly cGMP-activated cation channel activity guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding cGMP binding small molecule binding potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity protein-containing complex binding identical protein binding protein binding	multicellular organismal process system process nervous system process response to stimulus detection of stimulus sensory perception of chemical stimulus sensory perception response to chemical detection of chemical stimulus detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception chemotaxis taxis aerotaxis multicellular organismal process system process nervous system process response to stimulus detection of stimulus sensory perception of chemical stimulus sensory perception response to chemical detection of chemical stimulus detection of stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception chemotaxis taxis aerotaxis energy taxis response to external stimulus locomotion regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of cGMP-mediated signaling regulation of signaling negative regulation of cGMP-mediated signaling negative regulation of response to stimulus cGMP-mediated signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication response to oxygen levels response to abiotic stimulus calcium-mediated signaling reproductive process multicellular organismal reproductive process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization nervous system development generation of neurons anatomical structure morphogenesis neuron development positive regulation of growth regulation of growth growth positive regulation of growth rate regulation of growth rate axon extension axonogenesis regulation of cellular component size developmental growth regulation of biological quality developmental growth involved in morphogenesis regulation of cellular component organization regulation of developmental process cell growth regulation of axon extension regulation of extent of cell growth regulation of cell size neuron projection extension regulation of developmental growth developmental cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation regulation of anatomical structure size detection of carbon dioxide behavior chemosensory behavior regulation of cell differentiation regulation of neuron differentiation monoatomic cation transmembrane transport transmembrane transport localization transport monoatomic ion transmembrane transport monoatomic ion transport monoatomic cation transport establishment of localization phototransduction detection of light stimulus response to light stimulus detection of external stimulus detection of abiotic stimulus response to radiation olfactory behavior regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway thermosensory behavior response to temperature stimulus thermotaxis response to stress response to hyperoxia response to increased oxygen levels	membrane cellular anatomical entity membrane-bounded organelle cell projection ciliary inversin compartment organelle cilium plasma membrane bounded cell projection cell periphery plasma membrane somatodendritic compartment dendrite dendritic tree neuron projection membrane cellular anatomical entity membrane-bounded organelle cell projection ciliary inversin compartment organelle cilium plasma membrane bounded cell projection cell periphery plasma membrane somatodendritic compartment dendrite dendritic tree neuron projection non-motile cilium protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex intracellular cyclic nucleotide activated cation channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A, B, C, D	IPR018488	Cyclic nucleotide-binding, conserved site	Conserved Site
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG	Family
A, B, C, D	IPR000595	Cyclic nucleotide-binding domain	Domain
A, B, C, D	IPR032406	Cyclic nucleotide-gated channel, C-terminal leucine zipper domain	Domain
A, B, C, D	IPR018490	Cyclic nucleotide-binding domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Cyclic nucleotide-gated ion channel

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	Cyclic-nucleotide-gated (CNG) channel TAX-4, liganded open state

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.