5GVX

Structural insight into dephosphorylation by Trehalose 6-phosphate Phosphatase (OtsB2) from Mycobacterium Tuberculosis

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HAD_2	e5gvxA2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: HAD_2	ECOD (1.6)
A	Trehalose_PPase	e5gvxA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Trehalose_PPase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02358	Trehalose-phosphatase (Trehalose_PPase)	Trehalose-phosphatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Trehalose-phosphate phosphatase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding phosphoric ester hydrolase activity trehalose-phosphatase activity hydrolase activity, acting on ester bonds carbohydrate phosphatase activity phosphatase activity hydrolase activity catalytic activity sugar-phosphatase activity	carbohydrate metabolic process trehalose metabolic process carbohydrate biosynthetic process oligosaccharide metabolic process primary metabolic process disaccharide metabolic process disaccharide biosynthetic process organic substance metabolic process biosynthetic process oligosaccharide biosynthetic process trehalose biosynthetic process organic substance biosynthetic process metabolic process dephosphorylation carbohydrate metabolic process trehalose metabolic process carbohydrate biosynthetic process oligosaccharide metabolic process primary metabolic process disaccharide metabolic process disaccharide biosynthetic process organic substance metabolic process biosynthetic process oligosaccharide biosynthetic process trehalose biosynthetic process organic substance biosynthetic process metabolic process dephosphorylation cellular metabolic process phosphate-containing compound metabolic process cellular process phosphorus metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036412	HAD-like superfamily	Homologous Superfamily
A	IPR023214	HAD superfamily	Homologous Superfamily
A	IPR003337	Trehalose-phosphatase	Family
A	IPR006379	HAD-superfamily hydrolase, subfamily IIB	Family
A	IPR044651	Trehalose 6-phosphate OTSB-like	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.