Annotations: 5GRQ

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03344	e5grqA1	A: alpha bundles	X: N-cbl like	H: DAXX helical bundle domain (From Topology)	T: DAXX helical bundle domain	F: PF03344	ECOD (1.6)
B	PF03344	e5grqB1	A: alpha bundles	X: N-cbl like	H: DAXX helical bundle domain (From Topology)	T: DAXX helical bundle domain	F: PF03344	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.8.810	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B	1.10.8.810	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03344	Daxx N-terminal Rassf1C-interacting domain (Daxx)	Daxx N-terminal Rassf1C-interacting domain	The Daxx protein (also known as the Fas-binding protein) is thought to play a role in apoptosis. Daxx forms a complex with Axin [1]. Remodelling of the family to a short domain based on the PDB:2kzs structure gives a more representative family. DAXX ...	The Daxx protein (also known as the Fas-binding protein) is thought to play a role in apoptosis. Daxx forms a complex with Axin [1]. Remodelling of the family to a short domain based on the PDB:2kzs structure gives a more representative family. DAXX is a scaffold protein shown to play diverse roles in transcription and cell cycle regulation. This N-terminal domain folds into a left-handed four-helix bundle (H1, H2, H4, H5) that binds to the N-terminal residues of the tumour-suppressor Rassf1C [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Death domain-associated protein 6	p53 binding protein binding binding histone binding molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity enzyme regulator activity p53 binding protein binding binding histone binding molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity transcription coactivator activity transcription regulator activity transcription coregulator activity heat shock protein binding nuclear receptor binding nuclear androgen receptor binding transcription corepressor activity SUMO-modified protein reader activity modification-dependent protein binding ubiquitin-like protein reader activity identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process cellular response to stimulus cellular response to arsenic-containing substance response to stimulus response to sodium arsenite response to arsenic-containing substance response to inorganic substance cellular response to chemical stimulus response to chemical cellular response to salt cellular response to sodium arsenite response to salt response to organic substance intracellular receptor signaling pathway response to lipid signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound steroid hormone mediated signaling pathway cellular response to lipid nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway cellular response to heat cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death extrinsic apoptotic signaling pathway via death domain receptors cell surface receptor signaling pathway extrinsic apoptotic signaling pathway apoptotic signaling pathway cellular response to inorganic substance response to copper ion cellular response to metal ion response to metal ion cellular response to copper ion protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular component organization or biogenesis nucleosome assembly nucleosome organization intracellular signal transduction JNK cascade intracellular signaling cassette MAPK cascade organonitrogen compound metabolic process regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process regulation of protein ubiquitination protein ubiquitination macromolecule modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation phosphorus metabolic process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of phosphorus metabolic process regulation of phosphorylation regulation of catalytic activity regulation of transferase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process neuron intrinsic apoptotic signaling pathway in response to oxidative stress intrinsic apoptotic signaling pathway cellular response to nitrogen compound response to diamide cellular response to diamide response to nitrogen compound negative regulation of gene expression response to cadmium ion cellular response to cadmium ion	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol chromosome, centromeric region chromosome chromosomal region nucleoplasm nuclear body PML body
C, D	Transcriptional regulator ATRX	protein binding binding histone binding chromo shadow domain binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding protein binding binding histone binding chromo shadow domain binding protein domain specific binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding methylated histone binding modification-dependent protein binding methylation-dependent protein binding cation binding metal ion binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding ATP-dependent activity, acting on DNA ATP-dependent chromatin remodeler activity catalytic activity, acting on DNA DNA binding nucleic acid binding chromatin DNA binding DNA translocase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	developmental process multicellular organismal process limb development appendage development post-embryonic appendage morphogenesis forelimb morphogenesis multicellular organism development anatomical structure morphogenesis post-embryonic limb morphogenesis appendage morphogenesis anatomical structure development post-embryonic animal morphogenesis post-embryonic forelimb morphogenesis post-embryonic development developmental process multicellular organismal process limb development appendage development post-embryonic appendage morphogenesis forelimb morphogenesis multicellular organism development anatomical structure morphogenesis post-embryonic limb morphogenesis appendage morphogenesis anatomical structure development post-embryonic animal morphogenesis post-embryonic forelimb morphogenesis post-embryonic development limb morphogenesis spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process replication fork processing regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion, telomeric negative regulation of maintenance of sister chromatid cohesion regulation of cellular component organization regulation of cellular process negative regulation of maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion regulation of maintenance of mitotic sister chromatid cohesion, telomeric negative regulation of biological process negative regulation of cell cycle maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion, telomeric cellular component organization negative regulation of sister chromatid cohesion negative regulation of chromosome organization maintenance of mitotic sister chromatid cohesion negative regulation of cellular process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process regulation of biological process negative regulation of cellular component organization regulation of cell cycle process biological regulation chromosome organization sister chromatid cohesion regulation of chromosome organization negative regulation of cell cycle process regulation of organelle organization negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric regulation of maintenance of sister chromatid cohesion organelle organization negative regulation of organelle organization regulation of sister chromatid cohesion cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process microtubule cytoskeleton organization meiotic cell cycle meiotic spindle organization meiotic cell cycle process microtubule-based process cytoskeleton organization spindle organization subtelomeric heterochromatin formation telomere organization negative regulation of cellular metabolic process protein-DNA complex organization chromatin organization chromatin remodeling negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression constitutive heterochromatin formation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress DNA repair protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region positive regulation of organelle organization regulation of telomere maintenance positive regulation of cellular component organization positive regulation of biological process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization telomere maintenance positive regulation of DNA metabolic process regulation of DNA metabolic process cellular developmental process sex differentiation cell development epithelial cell differentiation Sertoli cell differentiation male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics cell differentiation reproductive structure development system development epithelium development gonad development reproductive system development Sertoli cell development animal organ development tissue development epithelial cell development multicellular organism growth developmental growth growth positive regulation of macromolecule biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process tube development seminiferous tubule development chromosome organization involved in meiotic cell cycle protein-DNA complex assembly cellular component biogenesis cellular component assembly protein-containing complex assembly nucleosome assembly nucleosome organization positive regulation of DNA replication nuclear DNA replication cell cycle DNA replication positive regulation of nuclear cell cycle DNA replication positive regulation of cell cycle process regulation of nuclear cell cycle DNA replication positive regulation of cell cycle regulation of DNA-templated DNA replication positive regulation of DNA-templated DNA replication regulation of DNA replication head development forebrain development brain development nervous system development central nervous system development signaling signal transduction by p53 class mediator DNA damage response, signal transduction by p53 class mediator intracellular signal transduction cell communication signal transduction in response to DNA damage signal transduction cellular response to nitrogen compound cellular response to inorganic substance response to organic substance response to nitrogen compound response to inorganic substance cellular response to hydroxyurea cellular response to chemical stimulus response to hydroxyurea response to chemical	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex protein-DNA complex chromatin heterochromatin chromosome, telomeric region chromosomal region nucleoplasm chromosome, subtelomeric region pericentric heterochromatin chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR046378	Daxx, histone-binding domain	Domain
A, B	IPR031333	Daxx, N-terminal Rassf1C-interacting domain	Domain
A, B	IPR038298	Daxx, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR046426	Daxx, histone-binding domain superfamily	Homologous Superfamily
C, D	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, D	IPR001650	Helicase, C-terminal domain-like	Domain
C, D	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
C, D	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
C, D	IPR041430	ATRX, ADD domain	Domain
C, D	IPR025766	ADD domain	Domain
C, D	IPR000330	SNF2, N-terminal	Domain
C, D	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
C, D	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UER7	adrenal cortex carcinoma neuroendocrine neoplasm adrenal carcinoma cervical cancer lung cancer triple-negative breast carcinoma endogenous depression Malignant neoplasm of pancreas pancreatic endocrine carcinoma autism spectrum disorder glioblastoma malignant pancreatic neoplasm pancreatic neoplasm
C, D	Pharos: P46100	alpha thalassemia-X-linked intellectual disability syndrome alpha-thalassemia-myelodysplastic syndrome intellectual disability malignant glioma myelodysplastic syndrome neuroblastoma glioblastoma mixed glioma neuroendocrine neoplasm Craniofacial Abnormalities salivary gland adenoid cystic carcinoma thoracic disease X-linked intellectual disability-hypotonic face syndrome adenoid cystic carcinoma autism, susceptibility to, X-linked 2 alpha thalassemia-X-linked intellectual disability syndrome alpha-thalassemia-myelodysplastic syndrome intellectual disability malignant glioma myelodysplastic syndrome neuroblastoma glioblastoma mixed glioma neuroendocrine neoplasm Craniofacial Abnormalities salivary gland adenoid cystic carcinoma thoracic disease X-linked intellectual disability-hypotonic face syndrome adenoid cystic carcinoma autism, susceptibility to, X-linked 2 cryptorchidism penile disease psoriasis Smith-Fineman-Myers syndrome ulcerative colitis lung adenocarcinoma malignant ependymoma malignant pancreatic neoplasm astrocytic tumor congenital anemia pancreatic endocrine carcinoma Pick disease rheumatoid arthritis glioma hereditary spastic paraplegia spinal cord disease Juberg-Marsidi syndrome lung cancer acute myeloid leukemia medulloblastoma atypical teratoid rhabdoid tumor brain disease osteogenesis imperfecta pancreatic neoplasm diabetes mellitus genetic endocrine growth disease large cell medulloblastoma lymphoplasmacytic lymphoma arthrogryposis microcephaly cancer ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.