Annotations: 5GKN

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Heme-dependent catalase-like	8037382	3001681	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Heme-dependent catalase-like	8037382	3001681	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Heme-dependent catalase-like	8037382	3001681	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Heme-dependent catalase-like	8037382	3001681	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00199	e5gknA3	A: beta barrels	X: Barrel domain in heme-dependent catalases (From Topology)	H: Barrel domain in heme-dependent catalases (From Topology)	T: Barrel domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
A	PF00199	e5gknA1	A: alpha bundles	X: First alpha-helical domain in heme-dependent catalases (From Topology)	H: First alpha-helical domain in heme-dependent catalases (From Topology)	T: First alpha-helical domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
A	PF06628	e5gknA2	A: alpha bundles	X: Second alpha-helical domain in heme-dependent catalases (From Topology)	H: Second alpha-helical domain in heme-dependent catalases (From Topology)	T: Second alpha-helical domain in heme-dependent catalases	F: PF06628	ECOD (1.6)
C	PF00199	e5gknC1	A: beta barrels	X: Barrel domain in heme-dependent catalases (From Topology)	H: Barrel domain in heme-dependent catalases (From Topology)	T: Barrel domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
C	PF00199	e5gknC3	A: alpha bundles	X: First alpha-helical domain in heme-dependent catalases (From Topology)	H: First alpha-helical domain in heme-dependent catalases (From Topology)	T: First alpha-helical domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
C	PF06628	e5gknC2	A: alpha bundles	X: Second alpha-helical domain in heme-dependent catalases (From Topology)	H: Second alpha-helical domain in heme-dependent catalases (From Topology)	T: Second alpha-helical domain in heme-dependent catalases	F: PF06628	ECOD (1.6)
B	PF00199	e5gknB1	A: beta barrels	X: Barrel domain in heme-dependent catalases (From Topology)	H: Barrel domain in heme-dependent catalases (From Topology)	T: Barrel domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
B	PF00199	e5gknB3	A: alpha bundles	X: First alpha-helical domain in heme-dependent catalases (From Topology)	H: First alpha-helical domain in heme-dependent catalases (From Topology)	T: First alpha-helical domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
B	PF06628	e5gknB2	A: alpha bundles	X: Second alpha-helical domain in heme-dependent catalases (From Topology)	H: Second alpha-helical domain in heme-dependent catalases (From Topology)	T: Second alpha-helical domain in heme-dependent catalases	F: PF06628	ECOD (1.6)
D	PF00199	e5gknD2	A: beta barrels	X: Barrel domain in heme-dependent catalases (From Topology)	H: Barrel domain in heme-dependent catalases (From Topology)	T: Barrel domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
D	PF00199	e5gknD3	A: alpha bundles	X: First alpha-helical domain in heme-dependent catalases (From Topology)	H: First alpha-helical domain in heme-dependent catalases (From Topology)	T: First alpha-helical domain in heme-dependent catalases	F: PF00199	ECOD (1.6)
D	PF06628	e5gknD1	A: alpha bundles	X: Second alpha-helical domain in heme-dependent catalases (From Topology)	H: Second alpha-helical domain in heme-dependent catalases (From Topology)	T: Second alpha-helical domain in heme-dependent catalases	F: PF06628	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.91.20	Few Secondary Structures	Irregular	Cytochrome C Oxidase	Chain J	CATH (4.3.0)
A	2.40.180.10	Mainly Beta	Beta Barrel	Catalase HpII, Chain A, domain 1	Catalase core domain	CATH (4.3.0)
A	1.20.1370.60	Mainly Alpha	Up-down Bundle	Hemocyanin, N-terminal domain		CATH (4.3.0)
C	4.10.91.20	Few Secondary Structures	Irregular	Cytochrome C Oxidase	Chain J	CATH (4.3.0)
C	2.40.180.10	Mainly Beta	Beta Barrel	Catalase HpII, Chain A, domain 1	Catalase core domain	CATH (4.3.0)
C	1.20.1370.60	Mainly Alpha	Up-down Bundle	Hemocyanin, N-terminal domain		CATH (4.3.0)
B	4.10.91.20	Few Secondary Structures	Irregular	Cytochrome C Oxidase	Chain J	CATH (4.3.0)
B	2.40.180.10	Mainly Beta	Beta Barrel	Catalase HpII, Chain A, domain 1	Catalase core domain	CATH (4.3.0)
B	1.20.1370.60	Mainly Alpha	Up-down Bundle	Hemocyanin, N-terminal domain		CATH (4.3.0)
D	4.10.91.20	Few Secondary Structures	Irregular	Cytochrome C Oxidase	Chain J	CATH (4.3.0)
D	2.40.180.10	Mainly Beta	Beta Barrel	Catalase HpII, Chain A, domain 1	Catalase core domain	CATH (4.3.0)
D	1.20.1370.60	Mainly Alpha	Up-down Bundle	Hemocyanin, N-terminal domain		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF06628	Catalase-related immune-responsive (Catalase-rel)	Catalase-related immune-responsive	-	Family
A, B, C, D	PF00199	Catalase (Catalase)	Catalase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Catalase	peroxidase activity oxidoreductase activity antioxidant activity catalase activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding protein binding enzyme binding cation binding ion binding peroxidase activity oxidoreductase activity antioxidant activity catalase activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding protein binding enzyme binding cation binding ion binding metal ion binding small molecule binding	cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to reactive oxygen species response to inorganic substance regulation of biological process regulation of cellular process positive regulation of cell division biological regulation positive regulation of biological process cell division positive regulation of cellular process regulation of cell division cellular response to stimulus cellular detoxification of hydrogen peroxide detoxification of inorganic compound detoxification cellular response to oxidative stress cellular response to chemical stress cellular oxidant detoxification cellular response to reactive oxygen species cellular response to stress cellular detoxification cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to toxic substance cellular response to chemical stimulus detoxification of hydrogen peroxide cellular response to toxic substance	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle peroxisome microbody catalase complex protein-containing complex catalytic complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR024708	Catalase active site	Active Site
A, B, C, D	IPR010582	Catalase immune-responsive domain	Domain
A, B, C, D	IPR002226	Catalase haem-binding site	Binding Site
A, B, C, D	IPR020835	Catalase superfamily	Homologous Superfamily
A, B, C, D	IPR024711	Catalase, mono-functional, haem-containing, clades 1 and 3	Family
A, B, C, D	IPR011614	Catalase core domain	Domain
A, B, C, D	IPR018028	Catalase, mono-functional, haem-containing	Family
A, B, C, D	IPR040333	Catalase, clade 3	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.