Annotations: 5GHR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21763	e5ghrA2	A: alpha arrays	X: HhH/H2TH	H: Cdc45 CID domain (From Topology)	T: Cdc45 CID domain	F: PF21763	ECOD (1.6)
A	PF02272	e5ghrA3	A: a+b three layers	X: C-terminal domain in DHH phosphoesterases (From Topology)	H: C-terminal domain in DHH phosphoesterases (From Topology)	T: C-terminal domain in DHH phosphoesterases	F: PF02272	ECOD (1.6)
A	PF01368	e5ghrA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: DHH phosphoesterases	F: PF01368	ECOD (1.6)
C	PF01368,PF21763	e5ghrC1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: DHH phosphoesterases	F: PF01368,PF21763	ECOD (1.6)
B	PF22090	e5ghrB1	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22090	ECOD (1.6)
D	PF22090	e5ghrD1	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22090	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.5.50	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)
D	3.40.5.50	Alpha Beta	3-Layer(aba) Sandwich	Ribosomal Protein L9	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF21763	DHH-CID domain (DHH_CID)	DHH-CID domain	DHH-CID (CMG Interacting Domain) domain is found in proteins that are members of DHH phosphatase family. This domain is located between the catalytic domains and consists of array of four helices with two 'kissing' loops. The DHH-CID domain contains ...	DHH-CID (CMG Interacting Domain) domain is found in proteins that are members of DHH phosphatase family. This domain is located between the catalytic domains and consists of array of four helices with two 'kissing' loops. The DHH-CID domain contains H2TH motif and is structurally very similar to proteins members of S13-like H2TH superfamily.	Domain
A, C	PF02272	DHHA1 domain (DHHA1)	DHHA1 domain	-	Family
A, C	PF01368	DHH family (DHH)	DHH family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	SsDNA-specific exonuclease	nuclease activity hydrolase activity, acting on ester bonds hydrolase activity exonuclease activity catalytic activity binding organic cyclic compound binding nucleic acid binding	-	-
B, D	Putative uncharacterized protein	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR001667	DDH domain	Domain
A, C	IPR048515	DHH-CID domain	Domain
A, C	IPR038763	DHH phosphoesterase superfamily	Homologous Superfamily
A, C	IPR003156	DHHA1 domain	Domain
B, D	IPR016745	Archaeal GINS complex, Gins51 subunit	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.