5FQ7

Crystal structure of the SusCD complex BT2261-2264 from Bacteroides thetaiotaomicron

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2B Superfamily	BT_2261-like	8106401	3002850	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	BT_2261-like	8106401	3002850	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12771	e5fq7A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12771	ECOD (1.6)
C	PF12771	e5fq7C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF12771	ECOD (1.6)
B	F_UNCLASSIFIED	e5fq7B2	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Ligand-gated protein channel	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF07715	e5fq7B1	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: TonB-dependent receptor plug domain (From Topology)	T: TonB-dependent receptor plug domain	F: PF07715	ECOD (1.6)
D	F_UNCLASSIFIED	e5fq7D1	A: beta barrels	X: Outer membrane meander beta-barrels	H: Porins	T: Ligand-gated protein channel	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF07715	e5fq7D2	A: a+b complex topology	X: N0 domain in phage tail proteins and secretins-like	H: TonB-dependent receptor plug domain (From Topology)	T: TonB-dependent receptor plug domain	F: PF07715	ECOD (1.6)
E	PF12888	e5fq7E1	A: beta barrels	X: Lipocalins/Streptavidin	H: Putative lipid binding protein BT_2261 (From Topology)	T: Putative lipid binding protein BT_2261	F: PF12888	ECOD (1.6)
F	PF12888	e5fq7F1	A: beta barrels	X: Lipocalins/Streptavidin	H: Putative lipid binding protein BT_2261 (From Topology)	T: Putative lipid binding protein BT_2261	F: PF12888	ECOD (1.6)
G	PF16403	e5fq7G1	A: beta sandwiches	X: A putative surface protein (From Topology)	H: A putative surface protein (From Topology)	T: A putative surface protein	F: PF16403	ECOD (1.6)
H	PF16403	e5fq7H1	A: beta sandwiches	X: A putative surface protein (From Topology)	H: A putative surface protein (From Topology)	T: A putative surface protein	F: PF16403	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.390	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
C	1.25.40.390	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)
E	2.40.128.220	Mainly Beta	Beta Barrel	Lipocalin		CATH (4.3.0)
F	2.40.128.220	Mainly Beta	Beta Barrel	Lipocalin		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF12771	Starch-binding associating with outer membrane (SusD-like_2)	Starch-binding associating with outer membrane	-	Repeat
B, D	PF07715	TonB-dependent Receptor Plug Domain (Plug)	TonB-dependent Receptor Plug Domain	The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens ...	The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.	Domain
E, F	PF12888	Lipid-binding putative hydrolase (Lipid_bd)	Lipid-binding putative hydrolase	-	Family
G, H	PF16404	BT_2262-like, C-terminal domain (BT_2262-like_C)	BT_2262-like, C-terminal domain	This domain found at the C-terminal end of proteins found in Bacteroidetes, including BT_2262 from Bacteroides thetaiotaomicron, a small outer membrane lipoprotein located on the periphery of the SusCD complex, which is essential for the import of ol ...	This domain found at the C-terminal end of proteins found in Bacteroidetes, including BT_2262 from Bacteroides thetaiotaomicron, a small outer membrane lipoprotein located on the periphery of the SusCD complex, which is essential for the import of oligosaccharides and for glycan degradation. This domain shows an eight-stranded beta-barrel with structural similarity to lipid binding domains. Its specific function remains unknown [1].	Domain
G, H	PF16403	Bacterial surface protein, Ig-like domain (Bact_surface_Ig-like)	Bacterial surface protein, Ig-like domain	This entry represents a bacterial immunoglobulin-like domain found in bacterial proteins, including Pesticidal crystal protein Cry22Aa from Bacillus thuringiensis, a protein with a toxic effect on several insect larvae and Chitinase 60 from Moritella ...	This entry represents a bacterial immunoglobulin-like domain found in bacterial proteins, including Pesticidal crystal protein Cry22Aa from Bacillus thuringiensis, a protein with a toxic effect on several insect larvae and Chitinase 60 from Moritella marina (Swiss:B1VBB0), responsible for degradation of krill chitin.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	BT_2263	cation binding ion binding binding metal ion binding small molecule binding	-	-
B, D	BT_2264	cation binding ion binding binding metal ion binding small molecule binding	-	cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane cellular anatomical entity
E, F	BT_2261	-	-	-
G, H	BT_2262	-	-	-
I, J [auth P]	PEPTIDE	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR041662	SusD-like 2	Family
A, C	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
B, D	IPR037066	TonB-dependent receptor, plug domain superfamily	Homologous Superfamily
B, D	IPR023997	TonB-dependent outer membrane protein SusC/RagA, conserved site	Conserved Site
B, D	IPR036942	TonB-dependent receptor-like, beta-barrel domain superfamily	Homologous Superfamily
B, D	IPR023996	TonB-dependent outer membrane protein, SusC/RagA	Family
B, D	IPR012910	TonB-dependent receptor, plug domain	Domain
E, F	IPR024404	Lipid-binding, putative	Family
E, F	IPR038668	Lipid-binding superfamily	Homologous Superfamily
G, H	IPR032179	Pesticidal crystal protein Cry22Aa, Ig-like domain	Domain
G, H	IPR032180	BT_2262-like, C-terminal domain	Domain
G, H	IPR013783	Immunoglobulin-like fold	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.