5FJW

Yeast delta-COP-I mu-homology domain complexed with Dsl1 WxWx(MSE) peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5fjwA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e5fjwB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e5fjwC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e5fjwE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e5fjwD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e5fjwF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e5fjwG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)
H	F_UNCLASSIFIED	e5fjwH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00928	Adaptor complexes medium subunit family (Adap_comp_sub)	Adaptor complexes medium subunit family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	COATOMER SUBUNIT DELTA	-	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport cellular localization establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport Golgi localization organelle localization protein localization localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport cellular localization establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport Golgi localization organelle localization protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization	membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex endomembrane system COPI-coated vesicle membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle membrane-bounded organelle protein-containing complex intracellular anatomical structure vesicle coat intracellular vesicle membrane protein complex endomembrane system COPI-coated vesicle membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle coated vesicle Golgi-associated vesicle vesicle COPI vesicle coat Golgi apparatus membrane cellular anatomical entity coated membrane intracellular membrane-bounded organelle COPI-coated vesicle membrane coated vesicle membrane cytoplasmic vesicle membrane organelle Golgi-associated vesicle membrane cytoplasm organelle membrane Golgi membrane
I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S]	PROTEIN TRANSPORT PROTEIN DSL1	-	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction cell cycle mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis regulation of cell cycle negative regulation of chromosome separation cell cycle process mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission biological regulation chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition peroxisome organization ER-dependent peroxisome organization establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex RZZ complex chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex RZZ complex chromosome chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle endomembrane system vesicle tethering complex Dsl1/NZR complex endoplasmic reticulum endoplasmic reticulum protein-containing complex organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR027059	Coatomer delta subunit	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR022775	AP complex, mu/sigma subunit	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036168	AP-2 complex subunit mu, C-terminal superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR028565	Mu homology domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR011012	Longin-like domain superfamily	Homologous Superfamily
I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S]	IPR021875	Retrograde transport protein Dsl1 N-terminal domain	Domain
I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S]	IPR038442	Dsl1, N-terminal domain superfamily	Homologous Superfamily
I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S]	IPR046362	Zw10/DSL1, C-terminal	Homologous Superfamily
I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], I [auth L], J [auth M], K [auth N], L [auth O], M [auth P], N [auth Q], O [auth R], P [auth S]	IPR021876	Retrograde transport protein Dsl1, C-terminal domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.