5FJV

Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02931	e5fjvA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
B	PF02931	e5fjvB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
C	PF02931	e5fjvC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
E	PF02931	e5fjvE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)
D	PF02931	e5fjvD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: PF02931	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
C	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
E	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
D	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2	neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity binding quaternary ammonium group binding small molecule binding heterocyclic compound binding transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity molecular transducer activity signaling receptor activity transmembrane signaling receptor activity acetylcholine receptor activity binding quaternary ammonium group binding small molecule binding heterocyclic compound binding transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ligand-gated channel activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity	cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling regulation of multicellular organismal process regulation of biological quality cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling regulation of multicellular organismal process regulation of biological quality signal transduction modulation of inhibitory postsynaptic potential trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of response to stimulus anterograde trans-synaptic signaling inhibitory postsynaptic potential regulation of cell communication cellular process regulation of membrane potential localization transport monoatomic ion transport establishment of localization cellular response to chemical stimulus response to chemical cellular response to nicotine response to nicotine synaptic transmission, cholinergic response to organic substance response to acetylcholine response to oxygen-containing compound response to nitrogen compound	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cell projection neuron projection plasma membrane bounded cell projection intercellular bridge protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex neuron projection cytoplasm cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, B, C, D, E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR002394	Nicotinic acetylcholine receptor	Family
A, B, C, D, E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, B, C, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, B, C, D, E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, B, C, D, E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, B, C, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E	Pharos: Q15822	autosomal dominant nocturnal frontal lobe epilepsy 4 autosomal dominant nocturnal frontal lobe epilepsy bipolar disorder pellagra anorexia nervosa cannabis dependence Epileptic encephalopathy lung benign neoplasm psoriasis attention deficit hyperactivity disorder, inattentive type depressive disorder hypertensive disorder lung carcinoma osteosarcoma autism spectrum disorder autosomal dominant nocturnal frontal lobe epilepsy 4 autosomal dominant nocturnal frontal lobe epilepsy bipolar disorder pellagra anorexia nervosa cannabis dependence Epileptic encephalopathy lung benign neoplasm psoriasis attention deficit hyperactivity disorder, inattentive type depressive disorder hypertensive disorder lung carcinoma osteosarcoma autism spectrum disorder epilepsy intellectual disability nicotine dependence

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.