5F5V

Crystal structure of the Snu23-Prp38-MFAP1(217-296) complex of Chaetomium thermophilum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d5f5vd_	All alpha proteins	alpha-alpha superhelix	Pre-mRNA splicing factor Prp38 N-terminal-like	Pre-mRNA splicing factor Prp38-like	Pre-mRNA splicing factor Prp38A	(Thermochaetoides thermophila DSM 1495 ) [TaxId: 759272 ],	SCOPe (2.08)
A	d5f5va_	All alpha proteins	alpha-alpha superhelix	Pre-mRNA splicing factor Prp38 N-terminal-like	Pre-mRNA splicing factor Prp38-like	Pre-mRNA splicing factor Prp38A	(Thermochaetoides thermophila DSM 1495 ) [TaxId: 759272 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	PRP38-like	8055807	3002318	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PRP38-like	8055807	3002318	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF03371	e5f5vD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Pre-mRNA-splicing factor 38A (From Topology)	T: Pre-mRNA-splicing factor 38A	F: PF03371	ECOD (1.6)
A	PF03371	e5f5vA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Pre-mRNA-splicing factor 38A (From Topology)	T: Pre-mRNA-splicing factor 38A	F: PF03371	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF03371	PRP38 family (PRP38)	PRP38 family	-	Family
B, E	PF06991	Microfibril-associated/Pre-mRNA processing (MFAP1)	Microfibril-associated/Pre-mRNA processing	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Prp38	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex
B, E	Putative uncharacterized protein	-	-	-
C, F	Zinc finger domain-containing protein	binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR005037	Pre-mRNA-splicing factor 38	Family
B, E	IPR033194	Microfibrillar-associated protein 1	Family
B, E	IPR009730	Micro-fibrillar-associated protein 1, C-terminal	Domain
C, F	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
C, F	IPR013087	Zinc finger C2H2-type	Domain
C, F	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
C, F	IPR040107	U4/U6.U5 small nuclear ribonucleoprotein component Snu23	Family
C, F	IPR022755	Zinc finger, double-stranded RNA binding	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.