Annotations: 5ET0

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ankyrin repeat	8089730	3000154	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ankyrin repeat	8089730	3000154	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12796	e5et0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF12796	ECOD (1.6)
C	PF12796	e5et0C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF12796	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Espin	SH3 domain binding protein binding binding protein domain specific binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding	behavior multicellular organismal process locomotory behavior system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus cellular component organization organelle organization actin filament network formation actin cytoskeleton organization actin filament organization actin filament-based process behavior multicellular organismal process locomotory behavior system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus cellular component organization organelle organization actin filament network formation actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization filopodium assembly regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization cell projection organization positive regulation of biological process regulation of filopodium assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly positive regulation of cell projection organization positive regulation of filopodium assembly positive regulation of cellular process regulation of biological process plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly regulation of cytoskeleton organization negative regulation of cellular component organization negative regulation of cytoskeleton organization negative regulation of biological process regulation of organelle organization negative regulation of organelle organization negative regulation of cellular process parallel actin filament bundle assembly actin filament bundle organization actin filament bundle assembly microvillar actin bundle assembly microvillus organization microvillus assembly	cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cellular anatomical entity cluster of actin-based cell projections plasma membrane bounded cell projection intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cellular anatomical entity cluster of actin-based cell projections plasma membrane bounded cell projection intracellular organelle intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle neuron spine synapse dendritic spine somatodendritic compartment postsynapse cell junction dendrite dendritic tree cytoplasm cytosol microvillus anchoring junction polymeric cytoskeletal fiber protein-containing complex actin filament filamentous actin supramolecular fiber supramolecular polymer supramolecular complex brush border
B, D	Myosin-IIIb	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein binding protein serine/threonine kinase activity cytoskeletal motor activity microfilament motor activity ATP-dependent activity	multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development multicellular organismal process inner ear receptor cell development cell projection organization sensory organ development epidermis development auditory receptor cell stereocilium organization neuron projection development epithelial cell differentiation hair cell differentiation multicellular organism development neuron differentiation cell differentiation inner ear development anatomical structure development animal organ morphogenesis system development developmental process embryonic organ morphogenesis mechanoreceptor differentiation epithelium development epidermal cell differentiation ear development embryonic morphogenesis nervous system development tissue development inner ear receptor cell differentiation generation of neurons auditory receptor cell development cellular developmental process cell development embryo development cell morphogenesis cellular component organization neurogenesis cellular component organization or biogenesis auditory receptor cell morphogenesis embryonic organ development ear morphogenesis plasma membrane bounded cell projection organization animal organ development inner ear auditory receptor cell differentiation cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis sensory organ morphogenesis neuron development inner ear morphogenesis cellular process inner ear receptor cell stereocilium organization response to stimulus regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of actin filament-based process actin cytoskeleton organization regulation of cellular component size biological regulation regulation of organelle organization organelle organization regulation of actin filament length regulation of actin cytoskeleton organization actin filament-based process regulation of biological quality cytoskeleton organization regulation of anatomical structure size cochlea development cochlea morphogenesis system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus sensory perception of light stimulus visual perception phosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process filopodium assembly positive regulation of cellular component organization positive regulation of biological process regulation of filopodium assembly plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly positive regulation of cell projection organization positive regulation of filopodium assembly positive regulation of cellular process positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly	photoreceptor inner segment cellular anatomical entity cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol photoreceptor inner segment cellular anatomical entity cell projection stereocilium actin-based cell projection organelle stereocilium tip stereocilium bundle neuron projection cluster of actin-based cell projections plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol filopodium tip filopodium intracellular organelle protein-containing complex cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle myosin complex membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium photoreceptor outer segment photoreceptor cell cilium

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR002110	Ankyrin repeat	Repeat
A, C	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, C	IPR003124	WH2 domain	Domain
B, D	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
B, D	IPR017441	Protein kinase, ATP binding site	Binding Site
B, D	IPR036083	Class III myosin, motor domain	Domain
B, D	IPR000719	Protein kinase domain	Domain
B, D	IPR000048	IQ motif, EF-hand binding site	Binding Site
B, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D	IPR001609	Myosin head, motor domain	Domain
B, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.