Annotations: 5EOA

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NEMO IKK-binding domain-like	8102934	3002761	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NEMO IKK-binding domain-like	8102934	3002761	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF11577	NF-kappa-B essential modulator NEMO (NEMO)	NF-kappa-B essential modulator NEMO	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Optineurin	polyubiquitin modification-dependent protein binding protein binding binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding identical protein binding	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane organic substance transport localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus macroautophagy positive regulation of xenophagy positive regulation of biological process positive regulation of cellular metabolic process xenophagy regulation of autophagy positive regulation of response to stimulus positive regulation of metabolic process positive regulation of response to external stimulus regulation of response to stress positive regulation of macroautophagy positive regulation of cellular process positive regulation of autophagy regulation of xenophagy regulation of cellular metabolic process regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of defense response positive regulation of cellular catabolic process regulation of metabolic process cell death protein localization to Golgi apparatus protein localization to organelle regulation of receptor recycling negative regulation of receptor recycling negative regulation of metabolic process regulation of macromolecule metabolic process receptor recycling organic substance metabolic process receptor metabolic process macromolecule metabolic process negative regulation of macromolecule metabolic process defense response to Gram-negative bacterium defense response to bacterium response to bacterium cellular component organization organelle organization Golgi ribbon formation cellular component organization or biogenesis Golgi organization endomembrane system organization response to organic substance cellular response to topologically incorrect protein cellular response to unfolded protein response to unfolded protein cellular response to chemical stimulus cellular response to stress response to chemical response to topologically incorrect protein cellular response to organic substance mitophagy organelle disassembly mitochondrion organization cellular component disassembly regulation of autophagy of mitochondrion in response to mitochondrial depolarization positive regulation of mitophagy in response to mitochondrial depolarization response to mitochondrial depolarisation positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization autophagy of mitochondrion parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen vacuole autophagosome endosome membrane membrane endosome intracellular vesicle recycling endosome endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle recycling endosome membrane vesicle membrane cytoplasmic vesicle vesicle organelle membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network Golgi membrane perinuclear region of cytoplasm
C, D	Serine/threonine-protein kinase TBK1	binding organic cyclic compound binding nucleic acid binding phosphoprotein binding protein binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein phosphatase binding binding organic cyclic compound binding nucleic acid binding phosphoprotein binding protein binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein phosphatase binding phosphatase binding enzyme binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity identical protein binding	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling cell population proliferation mononuclear cell proliferation dendritic cell proliferation leukocyte proliferation immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway cell surface receptor signaling pathway toll-like receptor 4 signaling pathway multicellular organismal process cellular biosynthetic process organic substance metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of multicellular organismal process regulation of biosynthetic process type I interferon production cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process regulation of type I interferon production positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation peptidyl-threonine modification peptidyl-threonine phosphorylation response to organic substance regulation of type I interferon-mediated signaling pathway response to cytokine interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of response to cytokine stimulus response to chemical response to type I interferon positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to organic substance regulation of cytokine-mediated signaling pathway cellular response to chemical stimulus type I interferon-mediated signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of interferon-beta production positive regulation of cytokine production positive regulation of cellular biosynthetic process catabolic process macroautophagy positive regulation of xenophagy autophagy xenophagy regulation of autophagy cellular catabolic process positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of autophagy regulation of xenophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling TORC1 signaling defense response to virus antiviral innate immune response response to virus negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling negative regulation of cellular process negative regulation of response to stimulus negative regulation of signal transduction inflammatory response negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process interferon-alpha production regulation of interferon-alpha production positive regulation of interferon-alpha production defense response to Gram-positive bacterium defense response to bacterium response to bacterium	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR034735	NEMO, Zinc finger	Domain
A, B	IPR021063	NF-kappa-B essential modulator NEMO, N-terminal	Domain
A, B	IPR032419	NF-kappa-B essential modulator NEMO, CC2-LZ domain	Domain
C, D	IPR017441	Protein kinase, ATP binding site	Binding Site
C, D	IPR041087	TANK binding kinase 1, ubiquitin-like domain	Domain
C, D	IPR000719	Protein kinase domain	Domain
C, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C, D	IPR041309	TANK-binding kinase 1, coiled-coil domain 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q96CV9	amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 12 primary open angle glaucoma bone Paget disease glaucoma glaucoma, normal tension, susceptibility to neurodegenerative disease open-angle glaucoma lung cancer malignant glioma myopathy oligodendroglioma acute myeloid leukemia ovarian cancer Amyotrophic Lateral Sclerosis With Dementia amyotrophic lateral sclerosis amyotrophic lateral sclerosis type 12 primary open angle glaucoma bone Paget disease glaucoma glaucoma, normal tension, susceptibility to neurodegenerative disease open-angle glaucoma lung cancer malignant glioma myopathy oligodendroglioma acute myeloid leukemia ovarian cancer Amyotrophic Lateral Sclerosis With Dementia psoriasis atypical teratoid rhabdoid tumor juvenile open angle glaucoma malignant colon neoplasm malignant mesothelioma glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma non-small cell lung carcinoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor spina bifida ductal breast carcinoma in situ glaucoma 3A hydrophthalmos
C, D	Pharos: Q9UHD2	amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 4 acute myeloid leukemia colorectal adenocarcinoma frontotemporal dementia with motor neuron disease Herpes encephalitis large cell medulloblastoma ovarian cancer aggressive systemic mastocytosis encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 glaucoma herpes simplex encephalitis, susceptibility to, 1 mast cell leukemia thrombocytopenia due to immune destruction glaucoma 1, open angle, P amyotrophic lateral sclerosis frontotemporal dementia and/or amyotrophic lateral sclerosis 4 acute myeloid leukemia colorectal adenocarcinoma frontotemporal dementia with motor neuron disease Herpes encephalitis large cell medulloblastoma ovarian cancer aggressive systemic mastocytosis encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8 glaucoma herpes simplex encephalitis, susceptibility to, 1 mast cell leukemia thrombocytopenia due to immune destruction glaucoma 1, open angle, P neurodegenerative disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.