Annotations: 5EN7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17814	e5en7A2	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
A	F_UNCLASSIFIED	e5en7A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: F_UNCLASSIFIED	ECOD (1.6)
C	PF17814	e5en7C1	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
C	F_UNCLASSIFIED	e5en7C2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF17814	e5en7E1	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
E	F_UNCLASSIFIED	e5en7E2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF17814	e5en7G1	A: alpha duplicates or obligate multimers	X: Lis-homology dimerization domain (From Topology)	H: Lis-homology dimerization domain (From Topology)	T: Lis-homology dimerization domain	F: PF17814	ECOD (1.6)
G	F_UNCLASSIFIED	e5en7G2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Helical domain in TOPLESS related protein 2 (TPR2) (From Topology)	T: Helical domain in TOPLESS related protein 2 (TPR2)	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF17814	LisH-like dimerisation domain (LisH_TPL)	LisH-like dimerisation domain	TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif [1].	Domain
B, D, F, H	PF07808	RED-like protein N-terminal region (RED_N)	RED-like protein N-terminal region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	SMU-1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process locomotion muscle structure development anatomical structure morphogenesis animal organ development animal organ morphogenesis muscle organ development muscle organ morphogenesis mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of cellular process alternative mRNA splicing, via spliceosome regulation of mRNA splicing, via spliceosome regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of mRNA processing regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process regulation of gene expression regulation of alternative mRNA splicing, via spliceosome regulation of macromolecule biosynthetic process regulation of mRNA metabolic process regulation of metabolic process behavior response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior embryo development ending in birth or egg hatching embryo development cellular developmental process cell development nervous system development generation of neurons neurogenesis neuron differentiation cell differentiation neuron development system development	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome U2-type spliceosomal complex U2-type precatalytic spliceosome
B, D, F, H	Suppressor of Mec and Unc defects	-	developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development locomotion muscle structure development anatomical structure morphogenesis animal organ development animal organ morphogenesis muscle organ development muscle organ morphogenesis developmental process multicellular organism development multicellular organismal process anatomical structure development nematode larval development larval development post-embryonic development locomotion muscle structure development anatomical structure morphogenesis animal organ development animal organ morphogenesis muscle organ development muscle organ morphogenesis RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process alternative mRNA splicing, via spliceosome regulation of mRNA splicing, via spliceosome regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of mRNA processing regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process regulation of gene expression regulation of alternative mRNA splicing, via spliceosome regulation of macromolecule biosynthetic process regulation of mRNA metabolic process regulation of metabolic process behavior response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus mechanosensory behavior embryo development ending in birth or egg hatching embryo development cellular developmental process cell development nervous system development generation of neurons neurogenesis neuron differentiation cell differentiation neuron development system development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, C, E, G	IPR006595	CTLH, C-terminal LisH motif	Domain
A, C, E, G	IPR045184	WD40 repeat-containing protein SMU1	Family
A, C, E, G	IPR001680	WD40 repeat	Repeat
A, C, E, G	IPR020472	G-protein beta WD-40 repeat	Repeat
A, C, E, G	IPR006594	LIS1 homology motif	Conserved Site
A, C, E, G	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B, D, F, H	IPR039896	Protein Red-like	Family
B, D, F, H	IPR012916	RED-like, N-terminal	Domain
B, D, F, H	IPR012492	Protein RED, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.