Annotations: 5EMJ

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Arginine methyltransferase C-terminal oligomerisation domain-like	8046793	3002184	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8053402	3000118	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Xylose isomerase-like	8053408	3000560	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF17286	e5emjA1	A: beta sandwiches	X: Arginine methyltransferase oligomerization subdomain (From Topology)	H: Arginine methyltransferase oligomerization subdomain (From Topology)	T: Arginine methyltransferase oligomerization subdomain	F: PF17286	ECOD (1.6)
A	PF17285	e5emjA3	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF17285	ECOD (1.6)
A	PF05185	e5emjA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: PF05185	ECOD (1.6)
B	PF00400	e5emjB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.150	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Divalent-metal-dependent TIM barrel enzymes	CATH (4.3.0)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)
A	2.70.160.11	Mainly Beta	Distorted Sandwich	Hnrnp arginine n-methyltransferase1	Hnrnp arginine n-methyltransferase1	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF17285	PRMT5 TIM barrel domain (PRMT5_TIM)	PRMT5 TIM barrel domain	This domain corresponds to the N-terminal TIM barrel domain from PRMT5 proteins..	Domain
A	PF05185	PRMT5 arginine-N-methyltransferase (PRMT5)	PRMT5 arginine-N-methyltransferase	The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase [3][4]. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.	Domain
A	PF17286	PRMT5 oligomerisation domain (PRMT5_C)	PRMT5 oligomerisation domain	-	Domain
B	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein arginine N-methyltransferase 5	p53 binding protein binding binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups arginine N-methyltransferase activity protein methyltransferase activity N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine N-methyltransferase activity histone H3 methyltransferase activity p53 binding protein binding binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups arginine N-methyltransferase activity protein methyltransferase activity N-methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine N-methyltransferase activity histone H3 methyltransferase activity histone modifying activity histone methyltransferase activity protein-arginine omega-N symmetric methyltransferase activity histone arginine N-methyltransferase activity protein heterodimerization activity protein dimerization activity ribonucleoprotein complex binding protein-containing complex binding histone H4 methyltransferase activity histone H4R3 methyltransferase activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity E-box binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding methyl-CpG binding small molecule binding identical protein binding	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression DNA-templated transcription termination macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression DNA-templated transcription termination macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process cellular process macromolecule metabolic process developmental process multicellular organismal process gland development animal organ development animal organ regeneration liver development regeneration multicellular organism development hepaticobiliary system development anatomical structure development liver regeneration system development cellular response to stimulus cellular response to nitrogen compound positive regulation of cell communication response to dopamine response to organic substance regulation of cellular process positive regulation of signal transduction response to stimulus dopamine receptor signaling pathway regulation of signal transduction regulation of dopamine receptor signaling pathway cell communication cellular response to catecholamine stimulus signal transduction regulation of G protein-coupled receptor signaling pathway response to organic cyclic compound regulation of biological process regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway response to organonitrogen compound cellular response to organic cyclic compound response to nitrogen compound positive regulation of G protein-coupled receptor signaling pathway cellular response to oxygen-containing compound positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to organonitrogen compound regulation of response to stimulus response to chemical G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway signaling cellular response to dopamine response to monoamine positive regulation of biological process positive regulation of response to stimulus cellular response to endogenous stimulus response to catecholamine cellular response to organic substance positive regulation of cellular process regulation of signaling response to endogenous stimulus biological regulation response to oxygen-containing compound cellular response to chemical stimulus cellular response to monoamine stimulus adenylate cyclase-modulating G protein-coupled receptor signaling pathway regulation of cell communication positive regulation of dopamine receptor signaling pathway positive regulation of signaling regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process ribonucleoprotein complex biogenesis mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile organonitrogen compound metabolic process protein methylation peptidyl-arginine methylation peptidyl-arginine N-methylation macromolecule methylation protein alkylation methylation macromolecule modification peptidyl-amino acid modification peptidyl-arginine modification protein metabolic process protein modification process regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade mitotic nuclear division regulation of cellular component organization regulation of cell cycle process organelle fission regulation of mitotic nuclear division regulation of organelle organization mitotic cell cycle regulation of mitotic cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cell cycle regulation of cell cycle cell cycle process Golgi ribbon formation Golgi organization endomembrane system organization signal transduction by p53 class mediator regulation of signal transduction by p53 class mediator positive regulation of nervous system development cellular developmental process regulation of developmental process cell development regulation of cell differentiation regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis gliogenesis positive regulation of cell differentiation cell differentiation regulation of multicellular organismal process positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation regulation of multicellular organismal development regulation of glial cell differentiation positive regulation of cell development nervous system development positive regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation positive regulation of multicellular organismal process regulation of oligodendrocyte differentiation negative regulation of developmental process negative regulation of biological process negative regulation of cellular process negative regulation of cell differentiation regulation of mRNA splicing, via spliceosome positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process positive regulation of mRNA processing positive regulation of mRNA splicing, via spliceosome positive regulation of cellular metabolic process positive regulation of biosynthetic process regulation of mRNA processing regulation of RNA splicing positive regulation of gene expression regulation of mRNA metabolic process positive regulation of RNA splicing positive regulation of cellular biosynthetic process protein-DNA complex organization chromatin organization chromatin remodeling endothelial cell activation cell activation	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen cytoplasm cytosol protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle Golgi apparatus endomembrane system methylosome
B	Methylosome protein 50	sequence-specific DNA binding DNA binding binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding nucleic acid binding heterocyclic compound binding methyl-CpG binding small molecule binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity sequence-specific DNA binding DNA binding binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding nucleic acid binding heterocyclic compound binding methyl-CpG binding small molecule binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal multicellular organismal process regulation of developmental process prostate gland development regulation of reproductive process reproductive process negative regulation of biological process gland development developmental process involved in reproduction multicellular organism development regulation of epithelial cell proliferation involved in prostate gland development negative regulation of cellular process anatomical structure development reproductive structure development regulation of multicellular organismal process epithelial cell proliferation system development developmental process negative regulation of cell population proliferation reproductive system development negative regulation of developmental process animal organ development epithelial cell proliferation involved in prostate gland development urogenital system development negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of reproductive process regulation of epithelial cell proliferation negative regulation of multicellular organismal process negative regulation of epithelial cell proliferation cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process sexual reproduction cellular developmental process cell development cellular process involved in reproduction in multicellular organism pattern specification process female gamete generation gamete generation oocyte development cell differentiation cell maturation oocyte axis specification oocyte construction multicellular organismal reproductive process oogenesis developmental maturation anatomical structure maturation germ cell development oocyte differentiation axis specification secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development epithelial cell differentiation prostate glandular acinus development epithelial cell differentiation involved in prostate gland development epithelium development tissue development glandular epithelial cell differentiation columnar/cuboidal epithelial cell differentiation regulation of mRNA splicing, via spliceosome mRNA processing positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process RNA processing positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process positive regulation of mRNA processing positive regulation of mRNA splicing, via spliceosome positive regulation of cellular metabolic process positive regulation of biosynthetic process regulation of mRNA processing RNA splicing regulation of RNA splicing mRNA metabolic process RNA splicing, via transesterification reactions positive regulation of gene expression mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process positive regulation of RNA splicing positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex methylosome methyltransferase complex transferase complex membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system protein-containing complex catalytic complex methylosome methyltransferase complex transferase complex cytosol cullin-RING ubiquitin ligase complex ubiquitin ligase complex Cul4-RING E3 ubiquitin ligase complex intracellular protein-containing complex Cul4B-RING E3 ubiquitin ligase complex nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035247	PRMT5, TIM barrel domain	Domain
A	IPR025799	Protein arginine N-methyltransferase	Family
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR007857	Protein arginine N-methyltransferase PRMT5	Family
A	IPR035248	PRMT5, oligomerisation domain	Domain
A	IPR035075	PRMT5 arginine-N-methyltransferase	Domain
B	IPR019775	WD40 repeat, conserved site	Conserved Site
B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B	IPR001680	WD40 repeat	Repeat
B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O14744	hypertensive disorder malignant ependymoma oligodendroglioma plantar fibromatosis psoriasis large cell medulloblastoma medulloblastoma osteosarcoma plasma cell myeloma Sjogren syndrome lung cancer non-small cell lung carcinoma ovarian cancer prostate carcinoma spina bifida
B	Pharos: Q9BQA1	lung cancer ovarian neoplasm Malignant neoplasm of ovary ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.