5EMA

Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal LRRC3B PDZ binding motif

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PDZ domain-like	8062276	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e5emaA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	ASP-ASP-ILE-SEP-THR-VAL-VAL	-	-	membrane cellular anatomical entity cell periphery extracellular matrix external encapsulating structure extracellular region extracellular space
A	Sorting nexin-27	binding phospholipid binding lipid binding phosphatidylinositol binding ionotropic glutamate receptor binding protein binding signaling receptor binding glutamate receptor binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding	protein localization positive regulation of AMPA glutamate receptor clustering regulation of localization regulation of postsynaptic membrane organization cellular localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of protein localization regulation of AMPA glutamate receptor clustering positive regulation of postsynaptic membrane organization positive regulation of biological process cellular component organization localization receptor clustering protein localization positive regulation of AMPA glutamate receptor clustering regulation of localization regulation of postsynaptic membrane organization cellular localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of protein localization regulation of AMPA glutamate receptor clustering positive regulation of postsynaptic membrane organization positive regulation of biological process cellular component organization localization receptor clustering cellular macromolecule localization cellular component organization or biogenesis synapse organization regulation of receptor clustering postsynaptic membrane organization regulation of protein localization to membrane positive regulation of cellular process membrane organization regulation of biological process postsynapse organization positive regulation of receptor clustering AMPA glutamate receptor clustering biological regulation positive regulation of protein localization to membrane glutamate receptor clustering neurotransmitter-gated ion channel clustering localization within membrane protein localization to membrane regulation of glutamate receptor clustering cell junction organization regulation of cellular localization macromolecule localization positive regulation of protein localization cellular process regulation of postsynaptic membrane neurotransmitter receptor levels regulation of biological quality cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor cellular response to stimulus signaling signal transduction cell communication establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization protein transport establishment of localization in cell intracellular protein transport vesicle-mediated transport endosomal transport developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development response to amine response to organic substance response to methamphetamine hydrochloride response to organonitrogen compound response to chemical response to nitrogen compound protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane establishment of protein localization to plasma membrane endocytic recycling vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport	protein-containing complex membrane membrane protein complex cellular anatomical entity retromer complex endomembrane system intracellular anatomical structure WASH complex cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle protein-containing complex membrane membrane protein complex cellular anatomical entity retromer complex endomembrane system intracellular anatomical structure WASH complex cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle early endosome endosome intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle cell periphery immunological synapse plasma membrane endosome membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
B	IPR000372	Leucine-rich repeat N-terminal domain	Domain
B	IPR001611	Leucine-rich repeat	Repeat
B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR037835	SNX27, RA domain	Domain
A	IPR001683	Phox homology	Domain
A	IPR000159	Ras-associating domain	Domain
A	IPR037831	SNX17/27/31-like	Family
A	IPR037827	SNX27, atypical FERM-like domain	Domain
A	IPR037833	SNX27, PX domain	Domain
A	IPR036034	PDZ superfamily	Homologous Superfamily
A	IPR036871	PX domain superfamily	Homologous Superfamily
A	IPR001478	PDZ domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q96PB8	colorectal cancer Pick disease primitive neuroectodermal tumor astrocytic tumor breast carcinoma Colorectal Neoplasms glioblastoma large cell medulloblastoma oligodendroglioma pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor gastric cancer hereditary diffuse gastric adenocarcinoma malignant ependymoma colorectal cancer Pick disease primitive neuroectodermal tumor astrocytic tumor breast carcinoma Colorectal Neoplasms glioblastoma large cell medulloblastoma oligodendroglioma pilocytic astrocytoma psoriasis atypical teratoid rhabdoid tumor gastric cancer hereditary diffuse gastric adenocarcinoma malignant ependymoma medulloblastoma ovarian cancer pituitary cancer breast cancer colorectal carcinoma gastric neoplasm interstitial cystitis malignant glioma myopathy

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.