5ELQ

Crystal structure of the SNX27 PDZ domain bound to the C-terminal DGKzeta PDZ binding motif

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PDZ domain	8062275	4001790	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PDZ domain-like	8062276	3000388	SCOP2 (2022-06-29)
C [auth B]	SCOP2B Superfamily	PDZ domain-like	8062276	3000388	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00595	e5elqA1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)
C [auth B]	PF00595	e5elqB1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PF00595	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Sorting nexin-27	binding phospholipid binding lipid binding phosphatidylinositol binding ionotropic glutamate receptor binding protein binding signaling receptor binding glutamate receptor binding phosphatidylinositol-3-phosphate binding phosphatidylinositol phosphate binding	protein localization positive regulation of AMPA glutamate receptor clustering regulation of localization regulation of postsynaptic membrane organization cellular localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of protein localization regulation of AMPA glutamate receptor clustering positive regulation of postsynaptic membrane organization positive regulation of biological process cellular component organization localization receptor clustering protein localization positive regulation of AMPA glutamate receptor clustering regulation of localization regulation of postsynaptic membrane organization cellular localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of protein localization regulation of AMPA glutamate receptor clustering positive regulation of postsynaptic membrane organization positive regulation of biological process cellular component organization localization receptor clustering cellular macromolecule localization cellular component organization or biogenesis synapse organization regulation of receptor clustering postsynaptic membrane organization regulation of protein localization to membrane positive regulation of cellular process membrane organization regulation of biological process postsynapse organization positive regulation of receptor clustering AMPA glutamate receptor clustering biological regulation positive regulation of protein localization to membrane glutamate receptor clustering neurotransmitter-gated ion channel clustering localization within membrane protein localization to membrane regulation of glutamate receptor clustering cell junction organization regulation of cellular localization macromolecule localization positive regulation of protein localization cellular process regulation of postsynaptic membrane neurotransmitter receptor levels regulation of biological quality cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor cellular response to stimulus signaling signal transduction cell communication establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization protein transport establishment of localization in cell intracellular protein transport vesicle-mediated transport endosomal transport developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development response to amine response to organic substance response to methamphetamine hydrochloride response to organonitrogen compound response to chemical response to nitrogen compound protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane establishment of protein localization to plasma membrane endocytic recycling vesicle-mediated transport to the plasma membrane endosome to plasma membrane protein transport	protein-containing complex membrane membrane protein complex cellular anatomical entity retromer complex endomembrane system intracellular anatomical structure WASH complex cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle protein-containing complex membrane membrane protein complex cellular anatomical entity retromer complex endomembrane system intracellular anatomical structure WASH complex cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle early endosome endosome intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle vesicle cell periphery immunological synapse plasma membrane endosome membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane Schaffer collateral - CA1 synapse
B [auth P], D [auth C]	GLU-ASP-GLN-GLU-THR-ALA-VAL	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups alkylglycerol kinase activity phosphotransferase activity, alcohol group as acceptor lipid kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups alkylglycerol kinase activity phosphotransferase activity, alcohol group as acceptor lipid kinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ATP-dependent diacylglycerol kinase activity cation binding metal ion binding	cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process phosphorus metabolic process phosphatidic acid biosynthetic process glycerophospholipid biosynthetic process phosphatidic acid metabolic process cellular metabolic process primary metabolic process phospholipid biosynthetic process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process organic substance metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process phosphorus metabolic process phosphatidic acid biosynthetic process glycerophospholipid biosynthetic process phosphatidic acid metabolic process cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process glycerolipid metabolic process metabolic process cellular process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation protein kinase C-activating G protein-coupled receptor signaling pathway cell communication G protein-coupled receptor signaling pathway signal transduction neutral lipid metabolic process diacylglycerol metabolic process acylglycerol metabolic process lipid phosphorylation phosphorylation lipid modification regulation of cell cycle phase transition DNA damage checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling cellular response to stress response to stress mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle DNA damage response signal transduction in response to DNA damage G1/S transition of mitotic cell cycle mitotic cell cycle phase transition cell migration cell motility multicellular organismal process regulation of body fluid levels wound healing cell activation hemostasis blood coagulation coagulation regulation of biological quality response to wounding platelet activation immune response-regulating cell surface receptor signaling pathway negative regulation of signaling positive regulation of biological process regulation of signal transduction regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process regulation of signaling cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response negative regulation of response to stimulus regulation of T cell receptor signaling pathway T cell receptor signaling pathway negative regulation of signal transduction negative regulation of T cell receptor signaling pathway regulation of response to stimulus negative regulation of immune system process immune system process regulation of immune response regulation of cell communication antigen receptor-mediated signaling pathway activation of immune response trans-synaptic signaling modulation of chemical synaptic transmission synaptic transmission, glutamatergic cell-cell signaling regulation of synaptic transmission, glutamatergic chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR037835	SNX27, RA domain	Domain
A, C [auth B]	IPR001683	Phox homology	Domain
A, C [auth B]	IPR000159	Ras-associating domain	Domain
A, C [auth B]	IPR037831	SNX17/27/31-like	Family
A, C [auth B]	IPR037827	SNX27, atypical FERM-like domain	Domain
A, C [auth B]	IPR037833	SNX27, PX domain	Domain
A, C [auth B]	IPR036034	PDZ superfamily	Homologous Superfamily
A, C [auth B]	IPR036871	PX domain superfamily	Homologous Superfamily
A, C [auth B]	IPR001478	PDZ domain	Domain
A, C [auth B]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
B [auth P], D [auth C]	IPR047484	Diacylglycerol kinase zeta, second protein kinase C conserved region 1	Domain
B [auth P], D [auth C]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B [auth P], D [auth C]	IPR000756	Diacylglycerol kinase, accessory domain	Domain
B [auth P], D [auth C]	IPR047485	Diacylglycerol kinase zeta, first protein kinase C conserved region 1	Domain
B [auth P], D [auth C]	IPR016064	NAD kinase/diacylglycerol kinase-like domain superfamily	Homologous Superfamily
B [auth P], D [auth C]	IPR002110	Ankyrin repeat	Repeat
B [auth P], D [auth C]	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
B [auth P], D [auth C]	IPR017438	Inorganic polyphosphate/ATP-NAD kinase, N-terminal	Homologous Superfamily
B [auth P], D [auth C]	IPR001206	Diacylglycerol kinase, catalytic domain	Domain
B [auth P], D [auth C]	IPR037607	Diacylglycerol kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth P], D [auth C]	Pharos: Q13574	myocardial infarction anorexia nervosa malignant ependymoma osteosarcoma autism spectrum disorder medulloblastoma peripheral arterial disease endogenous depression